Entry | Database: PDB / ID: 6d4g |
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Title | N-GTPase domain of p190RhoGAP-A |
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Components | Rho GTPase-activating protein 35 |
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Keywords | HYDROLASE / GTPase / pseudoGTPase / GTP / p190RhoGAP |
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Function / homology | Function and homology information
Sema4D mediated inhibition of cell attachment and migration / : / RHOJ GTPase cycle / : / RND2 GTPase cycle / RND1 GTPase cycle / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / RHOB GTPase cycle / CDC42 GTPase cycle / RHOD GTPase cycle ...Sema4D mediated inhibition of cell attachment and migration / : / RHOJ GTPase cycle / : / RND2 GTPase cycle / RND1 GTPase cycle / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / RHOB GTPase cycle / CDC42 GTPase cycle / RHOD GTPase cycle / RND3 GTPase cycle / RHOG GTPase cycle / RAC2 GTPase cycle / RHOQ GTPase cycle / RAC1 GTPase cycle / central nervous system neuron axonogenesis / neuron projection guidance / establishment or maintenance of actin cytoskeleton polarity / RHOA GTPase cycle / regulation of actin polymerization or depolymerization / : / positive regulation of cilium assembly / mammary gland development / camera-type eye development / negative regulation of vascular permeability / axonal fasciculation / GTPase activating protein binding / wound healing, spreading of cells / negative regulation of Rho protein signal transduction / regulation of cell size / regulation of axonogenesis / Rho protein signal transduction / forebrain development / GTPase activator activity / ciliary basal body / positive regulation of GTPase activity / neural tube closure / regulation of actin cytoskeleton organization / axon guidance / phospholipid binding / positive regulation of neuron projection development / cell migration / actin cytoskeleton / regulation of cell shape / GTPase activity / protein-containing complex binding / GTP binding / DNA binding / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function Rho GTPase-activating protein, pG1 and pG2 domain / p190RhoGAP, pG1 and pG2 domains / Rho GTPase-activating protein, FF domain / Rho GTPase-activating protein, pG2 domain / Rho GTPase-activating protein, pG1 domain / p190-A and -B Rho GAPs FF domain / pG1 pseudoGTPase domain profile. / pG2 pseudoGTPase domain profile. / FF domain / FF domain ...Rho GTPase-activating protein, pG1 and pG2 domain / p190RhoGAP, pG1 and pG2 domains / Rho GTPase-activating protein, FF domain / Rho GTPase-activating protein, pG2 domain / Rho GTPase-activating protein, pG1 domain / p190-A and -B Rho GAPs FF domain / pG1 pseudoGTPase domain profile. / pG2 pseudoGTPase domain profile. / FF domain / FF domain / FF domain superfamily / FF domain profile. / Contains two conserved F residues / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Rho GTPase activation protein / Small GTPase / Ras family / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Rattus norvegicus (Norway rat) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.8 Å |
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Authors | Stiegler, A.L. / Boggon, T.J. |
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Funding support | United States, 3items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM114621 | United States | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM102262 | United States | National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS085078 | United States |
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Citation | Journal: Structure / Year: 2018 Title: The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase. Authors: Stiegler, A.L. / Boggon, T.J. |
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History | Deposition | Apr 18, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 12, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 21, 2018 | Group: Data collection / Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first |
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Revision 1.2 | Dec 18, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Oct 4, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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