- PDB-2d86: Solution structure of the CH domain from human Vav-3 protein -
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Basic information
Entry
Database: PDB / ID: 2d86
Title
Solution structure of the CH domain from human Vav-3 protein
Components
Vav-3 protein
Keywords
SIGNALING PROTEIN / PROTEIN BINDING / all alpha / calponin homology domain / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
guanyl-nucleotide exchange factor activity => GO:0005085 / : / : / response to xenobiotic stimulus => GO:0009410 / vesicle fusion / regulation of small GTPase mediated signal transduction / lamellipodium assembly / regulation of cell size / epidermal growth factor receptor binding / small GTPase-mediated signal transduction ...guanyl-nucleotide exchange factor activity => GO:0005085 / : / : / response to xenobiotic stimulus => GO:0009410 / vesicle fusion / regulation of small GTPase mediated signal transduction / lamellipodium assembly / regulation of cell size / epidermal growth factor receptor binding / small GTPase-mediated signal transduction / regulation of GTPase activity / Fc-gamma receptor signaling pathway involved in phagocytosis / NRAGE signals death through JNK / Fc-epsilon receptor signaling pathway / immunological synapse / positive regulation of cell adhesion / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / positive regulation of B cell proliferation / GPVI-mediated activation cascade / FCERI mediated Ca+2 mobilization / neutrophil chemotaxis / GTPase activator activity / guanyl-nucleotide exchange factor activity / VEGFR2 mediated vascular permeability / integrin-mediated signaling pathway / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / platelet activation / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / G alpha (12/13) signalling events / DAP12 signaling / angiogenesis / positive regulation of apoptotic process / G protein-coupled receptor signaling pathway / DNA damage response / metal ion binding / cytosol Similarity search - Function
Conformer selection criteria: target function,structures with the lowest energy,structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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