登録情報 データベース : PDB / ID : 2cjs 構造の表示 ダウンロードとリンクタイトル Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules 要素REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2 UNC-13 HOMOLOG A 詳細キーワード EXOCYTOSIS / NEUROTRANSMITTER TRANSPORT / ZINC FINGER / SYNAPTOSOME / PHORBOL-ESTER BINDING / NEUROTRANSMITTER RELEASE / METAL-BINDING / PROTEIN- PROTEIN INTERACTIONS / RIM / MUNC13 / SYNAPSE / TRANSPORT / C2 DOMAINS機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of calcium-dependent activation of synaptic vesicle fusion / structural constituent of presynaptic active zone / maintenance of presynaptic active zone structure / cytoskeleton of presynaptic active zone / dense core granule priming / neuronal dense core vesicle exocytosis / diacylglycerol binding / spontaneous neurotransmitter secretion / regulation of synaptic vesicle priming / presynaptic dense core vesicle exocytosis ... regulation of calcium-dependent activation of synaptic vesicle fusion / structural constituent of presynaptic active zone / maintenance of presynaptic active zone structure / cytoskeleton of presynaptic active zone / dense core granule priming / neuronal dense core vesicle exocytosis / diacylglycerol binding / spontaneous neurotransmitter secretion / regulation of synaptic vesicle priming / presynaptic dense core vesicle exocytosis / synaptic vesicle docking / inhibitory synapse / calcium ion-regulated exocytosis of neurotransmitter / positive regulation of glutamate receptor signaling pathway / synaptic vesicle maturation / presynaptic active zone cytoplasmic component / positive regulation of synaptic plasticity / photoreceptor ribbon synapse / calcium-ion regulated exocytosis / innervation / positive regulation of dendrite extension / regulation of exocytosis / positive regulation of inhibitory postsynaptic potential / neurotransmitter secretion / regulation of short-term neuronal synaptic plasticity / regulation of amyloid precursor protein catabolic process / insulin secretion / syntaxin-1 binding / positive regulation of neurotransmitter secretion / syntaxin binding / synaptic vesicle priming / Golgi-associated vesicle / neuromuscular junction development / regulation of synaptic vesicle exocytosis / spectrin binding / exocytosis / presynaptic active zone / synaptic vesicle exocytosis / calyx of Held / positive regulation of excitatory postsynaptic potential / excitatory synapse / GABA-ergic synapse / amyloid-beta metabolic process / positive regulation of synaptic transmission / SNARE binding / synaptic membrane / synaptic transmission, glutamatergic / cell projection / establishment of localization in cell / regulation of membrane potential / long-term synaptic potentiation / intracellular protein transport / regulation of synaptic plasticity / neuromuscular junction / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / terminal bouton / phospholipid binding / synaptic vesicle membrane / small GTPase binding / presynapse / protein-macromolecule adaptor activity / presynaptic membrane / transmembrane transporter binding / cell differentiation / calmodulin binding / protein domain specific binding / axon / glutamatergic synapse / synapse / calcium ion binding / positive regulation of gene expression / protein-containing complex binding / protein-containing complex / identical protein binding / metal ion binding / plasma membrane 類似検索 - 分子機能 Wheat Germ Agglutinin (Isolectin 2); domain 1 - #120 / Rim-like / Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. ... Wheat Germ Agglutinin (Isolectin 2); domain 1 - #120 / Rim-like / Mammalian uncoordinated homology 13, domain 2 / Protein Unc-13 / Protein Unc-13, C2B domain / Munc13-homology domain 2 (MHD2) profile. / MUN domain / Munc13 homology 1 / MUN domain / Munc13-homology domain 1 (MHD1) profile. / Domain of Unknown Function (DUF1041) / Rab-binding domain / FYVE-type zinc finger / FYVE-type zinc finger / Rab-binding domain profile. / Zinc finger, FYVE-related / Zinc finger FYVE/FYVE-related type profile. / Wheat Germ Agglutinin (Isolectin 2); domain 1 / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / C2 domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-type / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Protein unc-13 homolog A / Regulating synaptic membrane exocytosis protein 2 類似検索 - 構成要素生物種 RATTUS NORVEGICUS (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.78 Å 詳細データ登録者 Lu, J. / Machius, M. / Dulubova, I. / Dai, H. / Sudhof, T.C. / Tomchick, D.R. / Rizo, J. 引用 残り1件を表示 表示を減らす履歴 登録 2006年4月6日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2006年6月7日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 1.2 2013年1月30日 Group : Database references / Derived calculations ... Database references / Derived calculations / Non-polymer description / Structure summary 改定 1.3 2019年1月30日 Group : Data collection / Experimental preparation / Otherカテゴリ : database_PDB_rev / database_PDB_rev_record ... database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol Item : _exptl_crystal_grow.method / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval改定 1.4 2024年5月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.