- PDB-2bye: NMR solution structure of phospholipase c epsilon RA 1 domain -
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Basic information
Entry
Database: PDB / ID: 2bye
Title
NMR solution structure of phospholipase c epsilon RA 1 domain
Components
PHOSPHOLIPASE C, EPSILON 1
Keywords
LIPASE / PHOSPHOLIPASE C EPSILON / RAS ASSOCIATION DOMAIN / UBIQUITIN SUPERFOLD
Function / homology
Function and homology information
phosphoinositide phospholipase C / diacylglycerol biosynthetic process / phosphatidylinositol phospholipase C activity / phospholipase C activity / glomerulus development / phosphatidylinositol-mediated signaling / Synthesis of IP3 and IP4 in the cytosol / lipid catabolic process / positive regulation of lamellipodium assembly / release of sequestered calcium ion into cytosol ...phosphoinositide phospholipase C / diacylglycerol biosynthetic process / phosphatidylinositol phospholipase C activity / phospholipase C activity / glomerulus development / phosphatidylinositol-mediated signaling / Synthesis of IP3 and IP4 in the cytosol / lipid catabolic process / positive regulation of lamellipodium assembly / release of sequestered calcium ion into cytosol / guanyl-nucleotide exchange factor activity / calcium-mediated signaling / epidermal growth factor receptor signaling pathway / small GTPase binding / lamellipodium / phospholipase C-activating G protein-coupled receptor signaling pathway / Ras protein signal transduction / intracellular signal transduction / Golgi membrane / enzyme binding / metal ion binding / plasma membrane / cytosol Similarity search - Function
Method: RESTRAINED SIMULATED ANNEALING, WATER REFINEMENT / Software ordinal: 1 Details: AB INITIO SIMULATED ANNEALING PROTOCOL WITH CARTESIAN MOLECULAR DYNAMICS AND TORSION ANGLE DYNAMICS SIMULATED ANNEALING. A FINAL STEP OF RESTRAINED MOLECULAR DYNAMICS WITH EXPLICIT INCLUSION OF SOLVENT.
NMR ensemble
Conformer selection criteria: LOWEST ENERGY STRUCTURE WITH NO RESTRAINT VIOLATIONS Conformers calculated total number: 100 / Conformers submitted total number: 20
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