Entry Database : PDB / ID : 1yrk Structure visualization Downloads & linksTitle The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain Components13-residue peptide Protein kinase C, delta type DetailsKeywords PROTEIN BINDING / C2 domainFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / endolysosome / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction ... positive regulation of phospholipid scramblase activity / positive regulation of glucosylceramide catabolic process / positive regulation of sphingomyelin catabolic process / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / regulation of ceramide biosynthetic process / HuR (ELAVL1) binds and stabilizes mRNA / endolysosome / positive regulation of ceramide biosynthetic process / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction / negative regulation of filopodium assembly / DAG and IP3 signaling / protein kinase C / cellular response to hydroperoxide / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / Effects of PIP2 hydrolysis / negative regulation of actin filament polymerization / negative regulation of platelet aggregation / positive regulation of endodeoxyribonuclease activity / neutrophil activation / regulation of signaling receptor activity / cellular response to angiotensin / Calmodulin induced events / intrinsic apoptotic signaling pathway in response to oxidative stress / Fc-gamma receptor signaling pathway involved in phagocytosis / activation of protein kinase activity / B cell proliferation / Apoptotic cleavage of cellular proteins / insulin receptor substrate binding / RHO GTPases Activate NADPH Oxidases / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / positive regulation of protein dephosphorylation / enzyme activator activity / regulation of mRNA stability / negative regulation of insulin receptor signaling pathway / SHC1 events in ERBB2 signaling / post-translational protein modification / cell chemotaxis / positive regulation of superoxide anion generation / VEGFR2 mediated cell proliferation / negative regulation of MAP kinase activity / negative regulation of protein binding / regulation of actin cytoskeleton organization / positive regulation of apoptotic signaling pathway / peptidyl-threonine phosphorylation / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / CLEC7A (Dectin-1) signaling / nuclear matrix / negative regulation of inflammatory response / G alpha (z) signalling events / cellular response to hydrogen peroxide / positive regulation of protein import into nucleus / cellular response to UV / KEAP1-NFE2L2 pathway / Interferon gamma signaling / azurophil granule lumen / cellular senescence / cell-cell junction / peptidyl-serine phosphorylation / protein stabilization / protein kinase activity / intracellular signal transduction / defense response to bacterium / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / DNA damage response / Neutrophil degranulation / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / signal transduction / mitochondrion / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. ... Novel protein kinase C delta, catalytic domain / Protein kinase C, delta / Protein kinase C delta/epsilon/eta/theta, C2 domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.7 Å DetailsAuthors Benes, C.H. / Wu, N. / Elia, A.E. / Dharia, T. / Cantley, L.C. / Soltoff, S.P. CitationJournal : Cell(Cambridge,Mass.) / Year : 2005Title : The C2 domain of PKCdelta is a phosphotyrosine binding domain.Authors : Benes, C.H. / Wu, N. / Elia, A.E. / Dharia, T. / Cantley, L.C. / Soltoff, S.P. History Deposition Feb 3, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 26, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
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