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TitleStructural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon.
Journal, issue, pagesMol. Cell, Vol. 21, Page 495-, Year 2006
Publish dateAug 1, 2005 (structure data deposition date)
AuthorsBunney, T.D. / Harris, R. / Gandarillas, N.L. / Josephs, M.B. / Roe, S.M. / Sorli, S.C. / Paterson, H.F. / Rodrigues-Lima, F. / Esposito, D. / Ponting, C.P. ...Bunney, T.D. / Harris, R. / Gandarillas, N.L. / Josephs, M.B. / Roe, S.M. / Sorli, S.C. / Paterson, H.F. / Rodrigues-Lima, F. / Esposito, D. / Ponting, C.P. / Gierschik, P. / Pearl, L.H. / Driscoll, P.C. / Katan, M.
External linksMol. Cell / PubMed:16483931
MethodsNMR (solution) / X-ray diffraction
Resolution1.9 Å
Structure data

PDB-2bye:
NMR solution structure of phospholipase c epsilon RA 1 domain
Method: SOLUTION NMR

PDB-2byf:
NMR solution structure of phospholipase c epsilon RA 2 domain
Method: SOLUTION NMR

PDB-2c5l:
Structure of PLC epsilon Ras association domain with hRas
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPASE / PHOSPHOLIPASE C EPSILON / RAS ASSOCIATION DOMAIN / UBIQUITIN SUPERFOLD / RAS BINDING DOMAIN / SIGNALING PROTEIN / SIGNALING PROTEIN-COMPLEX / RAS / ONCOGENE / GTP-BINDING / NUCLEOTIDE- BINDING / DISEASE MUTATION / LIPOPROTEIN / PALMITATE / PRENYLATION / PROTO-ONCOGENE

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