登録情報 | データベース: PDB / ID: 1yje |
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タイトル | Crystal structure of the rNGFI-B ligand-binding domain |
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要素 | Orphan nuclear receptor NR4A1 |
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キーワード | TRANSCRIPTION / NGFI-B / Nur77 / Nuclear receptor / ligand-binding domain / novel coregulator interface / cell-specific / Structural Proteomics in Europe / SPINE / Structural Genomics |
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機能・相同性 | 機能・相同性情報
AKT phosphorylates targets in the nucleus / neurotransmitter secretion involved in regulation of skeletal muscle contraction / regulation of type B pancreatic cell proliferation / non-canonical inflammasome complex assembly / detection of lipopolysaccharide / cellular response to corticotropin-releasing hormone stimulus / endothelial cell chemotaxis / Nuclear Receptor transcription pathway / nuclear glucocorticoid receptor binding / cellular response to fibroblast growth factor stimulus ...AKT phosphorylates targets in the nucleus / neurotransmitter secretion involved in regulation of skeletal muscle contraction / regulation of type B pancreatic cell proliferation / non-canonical inflammasome complex assembly / detection of lipopolysaccharide / cellular response to corticotropin-releasing hormone stimulus / endothelial cell chemotaxis / Nuclear Receptor transcription pathway / nuclear glucocorticoid receptor binding / cellular response to fibroblast growth factor stimulus / cell migration involved in sprouting angiogenesis / : / fat cell differentiation / skeletal muscle cell differentiation / transcription factor binding / negative regulation of cell cycle / cellular response to vascular endothelial growth factor stimulus / response to electrical stimulus / positive regulation of endothelial cell proliferation / response to amphetamine / lipopolysaccharide binding / nuclear receptor activity / sequence-specific double-stranded DNA binding / presynapse / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / nuclear membrane / transcription regulator complex / sequence-specific DNA binding / transcription by RNA polymerase II / response to lipopolysaccharide / DNA-binding transcription factor activity, RNA polymerase II-specific / inflammatory response / positive regulation of apoptotic process / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / apoptotic process / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / mitochondrion / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol類似検索 - 分子機能 Orphan nuclear receptor, HMR type / Orphan nuclear receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ...Orphan nuclear receptor, HMR type / Orphan nuclear receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Nuclear receptor subfamily 4 group A member 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Flaig, R. / Greschik, H. / Peluso-Iltis, C. / Moras, D. / Structural Proteomics in Europe (SPINE) |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2005 タイトル: Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain. 著者: Flaig, R. / Greschik, H. / Peluso-Iltis, C. / Moras, D. |
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履歴 | 登録 | 2005年1月14日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2005年2月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2017年10月11日 | Group: Refinement description / カテゴリ: software / Item: _software.classification / _software.name |
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改定 1.4 | 2023年10月25日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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