登録情報 | データベース: PDB / ID: 1xap |
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タイトル | Structure of the ligand binding domain of the Retinoic Acid Receptor beta |
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要素 | Retinoic acid receptor beta |
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キーワード | TRANSCRIPTION / nuclear receptor / ligand binding domain / retinoic acid receptor beta / TTNPB |
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機能・相同性 | 機能・相同性情報
ventricular cardiac muscle cell differentiation / embryonic eye morphogenesis / glandular epithelial cell development / growth plate cartilage development / embryonic digestive tract development / striatum development / neural precursor cell proliferation / negative regulation of chondrocyte differentiation / embryonic hindlimb morphogenesis / ureteric bud development ...ventricular cardiac muscle cell differentiation / embryonic eye morphogenesis / glandular epithelial cell development / growth plate cartilage development / embryonic digestive tract development / striatum development / neural precursor cell proliferation / negative regulation of chondrocyte differentiation / embryonic hindlimb morphogenesis / ureteric bud development / regulation of myelination / Signaling by Retinoic Acid / retinoic acid receptor signaling pathway / heterocyclic compound binding / nuclear retinoid X receptor binding / hormone-mediated signaling pathway / neurogenesis / negative regulation of stem cell proliferation / stem cell proliferation / Nuclear Receptor transcription pathway / multicellular organism growth / nuclear receptor activity / Activation of anterior HOX genes in hindbrain development during early embryogenesis / sequence-specific double-stranded DNA binding / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / positive regulation of apoptotic process / chromatin / protein-containing complex binding / apoptotic process / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 : / : / Retinoic acid receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. ...: / : / Retinoic acid receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Germain, P. / Kammerer, S. / Peluso-Iltis, C. / Tortolani, D. / Zusi, F.C. / Starrett, J. / Lapointe, P. / Daris, J.P. / Marinier, A. / De Lera, A.R. ...Germain, P. / Kammerer, S. / Peluso-Iltis, C. / Tortolani, D. / Zusi, F.C. / Starrett, J. / Lapointe, P. / Daris, J.P. / Marinier, A. / De Lera, A.R. / Rochel, N. / Gronemeyer, H. |
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引用 | ジャーナル: Embo Rep. / 年: 2004 タイトル: Rational design of RAR-selective ligands revealed by RARbeta crystal structure 著者: Germain, P. / Kammerer, S. / Perez, E. / Peluso-Iltis, C. / Tortolani, D. / Zusi, F.C. / Starrett, J. / Lapointe, P. / Daris, J.P. / Marinier, A. / De Lera, A.R. / Rochel, N. / Gronemeyer, H. |
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履歴 | 登録 | 2004年8月26日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2004年11月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2016年12月28日 | Group: Database references |
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改定 1.4 | 2023年10月25日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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