- PDB-1wr4: Solution structure of the second WW domain of Nedd4-2 -
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Basic information
Entry
Database: PDB / ID: 1wr4
Title
Solution structure of the second WW domain of Nedd4-2
Components
ubiquitin-protein ligase Nedd4-2
Keywords
LIGASE / all-beta
Function / homology
Function and homology information
positive regulation of caveolin-mediated endocytosis / RING-type E3 ubiquitin transferase (cysteine targeting) / Downregulation of SMAD2/3:SMAD4 transcriptional activity / negative regulation of sodium ion transport / negative regulation of potassium ion transmembrane transport / regulation of sodium ion transmembrane transport / Stimuli-sensing channels / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of sodium ion transport / ventricular cardiac muscle cell action potential ...positive regulation of caveolin-mediated endocytosis / RING-type E3 ubiquitin transferase (cysteine targeting) / Downregulation of SMAD2/3:SMAD4 transcriptional activity / negative regulation of sodium ion transport / negative regulation of potassium ion transmembrane transport / regulation of sodium ion transmembrane transport / Stimuli-sensing channels / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of sodium ion transport / ventricular cardiac muscle cell action potential / potassium channel inhibitor activity / HECT-type E3 ubiquitin transferase / negative regulation of systemic arterial blood pressure / sodium channel inhibitor activity / regulation of bicellular tight junction assembly / sodium ion transport / regulation of dendrite morphogenesis / protein monoubiquitination / regulation of sodium ion transport / response to salt stress / multivesicular body / establishment of localization in cell / regulation of protein stability / protein polyubiquitination / positive regulation of protein catabolic process / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / ubiquitin-dependent protein catabolic process / cell differentiation / protein ubiquitination / Golgi apparatus / cytoplasm Similarity search - Function
E3 ubiquitin-protein ligase, SMURF1 type / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / WW domain / WW/rsp5/WWP domain signature. ...E3 ubiquitin-protein ligase, SMURF1 type / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily Similarity search - Domain/homology
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