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- PDB-1sco: SCORPION TOXIN (OSK1 TOXIN) WITH HIGH AFFINITY FOR SMALL CONDUCTA... -

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Basic information

Entry
Database: PDB / ID: 1sco
TitleSCORPION TOXIN (OSK1 TOXIN) WITH HIGH AFFINITY FOR SMALL CONDUCTANCE CA(2+)-ACTIVATED K+ CHANNEL IN NEUROBLASTOMA-X-GLUOMA NG 108-15 HYBRID CELLS, NMR, 30 STRUCTURES
ComponentsSCORPION TOXIN OSK1
KeywordsPOTASSIUM CHANNEL INHIBITOR
Function / homologyScorpion short toxins signature. / Scorpion short chain toxin, potassium channel inhibitor / Scorpion short toxin, BmKK2 / Knottin, scorpion toxin-like superfamily / ion channel inhibitor activity / potassium channel regulator activity / toxin activity / extracellular region / Potassium channel toxin alpha-KTx 3.7
Function and homology information
Biological speciesOrthochirus scrobiculosus (Central Asian scorpion)
MethodSOLUTION NMR
AuthorsJaravine, V.A. / Nolde, D.E. / Pluzhnikov, K.A. / Grishin, E.V. / Arseniev, A.S.
CitationJournal: Biochemistry / Year: 1997
Title: Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom.
Authors: Jaravine, V.A. / Nolde, D.E. / Reibarkh, M.J. / Korolkova, Y.V. / Kozlov, S.A. / Pluzhnikov, K.A. / Grishin, E.V. / Arseniev, A.S.
History
DepositionApr 1, 1996Processing site: BNL
Revision 1.0Jan 27, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: SCORPION TOXIN OSK1


Theoretical massNumber of molelcules
Total (without water)4,2211
Polymers4,2211
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)30 / -
Representative

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Components

#1: Protein/peptide SCORPION TOXIN OSK1 / LENATOXIN


Mass: 4221.267 Da / Num. of mol.: 1 / Source method: isolated from a natural source
Source: (natural) Orthochirus scrobiculosus (Central Asian scorpion)
References: UniProt: P55896

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 3.0 / Temperature: 303 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: SYBYL / Version: 6.2 / Developer: TRIPOS / Classification: refinement
NMR ensembleConformers submitted total number: 30

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