Entry | Database: PDB / ID: 1w2f |
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Title | Human Inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine |
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Components | INOSITOL-TRISPHOSPHATE 3-KINASE A |
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Keywords | TRANSFERASE / INOSITOL PHOSPHATE KINASE / CALMODULIN-BINDING |
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Function / homology | Function and homology information
inositol-trisphosphate 3-kinase / inositol-1,4,5-trisphosphate 3-kinase activity / inositol hexakisphosphate kinase activity / inositol phosphate biosynthetic process / modification of postsynaptic actin cytoskeleton / inositol metabolic process / positive regulation of dendritic spine morphogenesis / postsynaptic actin cytoskeleton / calcium/calmodulin-dependent protein kinase activity / dendritic spine maintenance ...inositol-trisphosphate 3-kinase / inositol-1,4,5-trisphosphate 3-kinase activity / inositol hexakisphosphate kinase activity / inositol phosphate biosynthetic process / modification of postsynaptic actin cytoskeleton / inositol metabolic process / positive regulation of dendritic spine morphogenesis / postsynaptic actin cytoskeleton / calcium/calmodulin-dependent protein kinase activity / dendritic spine maintenance / Synthesis of IP3 and IP4 in the cytosol / phosphatidylinositol phosphate biosynthetic process / cellular response to calcium ion / regulation of synaptic plasticity / small GTPase binding / response to calcium ion / actin cytoskeleton organization / dendritic spine / cytoskeleton / calmodulin binding / glutamatergic synapse / signal transduction / ATP binding / nucleus / cytosol / cytoplasmSimilarity search - Function Inositol polyphosphate kinase / Inositol polyphosphate kinase / Inositol polyphosphate kinase superfamily / Inositol polyphosphate kinase / D-amino Acid Aminotransferase; Chain A, domain 1 / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / OTHER / Resolution: 1.8 Å |
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Authors | Gonzalez, B. / Schell, M.J. / Irvine, R.F. / Williams, R.L. |
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Citation | Journal: Mol.Cell / Year: 2004 Title: Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase Authors: Gonzalez, B. / Schell, M.J. / Letcher, A.J. / Veprintsev, D.B. / Irvine, R.F. / Williams, R.L. |
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History | Deposition | Jul 1, 2004 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 9, 2004 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Oct 16, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Structure summary Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_entry_details / pdbx_modification_feature / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flag |
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