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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1ucb | ||||||
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タイトル | STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ) | ||||||
![]() | (CHIMERIC HUMAN/MOUSE IGG FAB FRAGMENT BR96) x 2 | ||||||
![]() | IMMUNOGLOBULIN / FAB / ANTIBODY / ANTI-TUMOR / CHIMERA | ||||||
機能・相同性 | ![]() IgD immunoglobulin complex / IgA immunoglobulin complex / IgM immunoglobulin complex / IgE immunoglobulin complex / CD22 mediated BCR regulation / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement / immunoglobulin mediated immune response ...IgD immunoglobulin complex / IgA immunoglobulin complex / IgM immunoglobulin complex / IgE immunoglobulin complex / CD22 mediated BCR regulation / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement / immunoglobulin mediated immune response / FCGR activation / Role of LAT2/NTAL/LAB on calcium mobilization / Role of phospholipids in phagocytosis / Scavenging of heme from plasma / antigen binding / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of Complement cascade / Cell surface interactions at the vascular wall / B cell receptor signaling pathway / FCGR3A-mediated phagocytosis / FCERI mediated MAPK activation / FCERI mediated NF-kB activation / Regulation of actin dynamics for phagocytic cup formation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / blood microparticle / adaptive immune response / Potential therapeutics for SARS / immune response / extracellular space / extracellular exosome / extracellular region / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() ![]() | ||||||
![]() | Sheriff, S. / Bajorath, J. | ||||||
![]() | ![]() タイトル: X-ray structure of the uncomplexed anti-tumor antibody BR96 and comparison with its antigen-bound form. 著者: Sheriff, S. / Chang, C.Y. / Jeffrey, P.D. / Bajorath, J. #1: ![]() タイトル: Crystallization and Preliminary X-Ray Analysis of the Monoclonal Anti-Tumor Antibody Br96 and its Complex with the Lewis Y Determinant 著者: Chang, C.Y. / Jeffrey, P.D. / Bajorath, J. / Hellstrom, I. / Hellstrom, K.E. / Sheriff, S. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 96 KB | 表示 | ![]() |
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PDB形式 | ![]() | 73.3 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 433.8 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 441.1 KB | 表示 | |
XML形式データ | ![]() | 17.6 KB | 表示 | |
CIF形式データ | ![]() | 23.7 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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要素
#1: 抗体 | 分子量: 24077.883 Da / 分子数: 1 断片: MOUSE VH AND VL DOMAINS, HUMAN CL KAPPA AND CH1 IGG1 DOMAINS 由来タイプ: 組換発現 / 由来: (組換発現) ![]() 解説: MOUSE/HUMAN CHIMERA. MOUSE HYBRIDOMA PRODUCED BY FUSIONING BALB/C SPLEEN CELLS WITH 2X63-AG 8.653 MOUSE MYELOMA CELLS. HUMAN CONSTANT REGIONS INTRODUCED BY HOMOLOGOUS RECOMBINATION. CL IS ...解説: MOUSE/HUMAN CHIMERA. MOUSE HYBRIDOMA PRODUCED BY FUSIONING BALB/C SPLEEN CELLS WITH 2X63-AG 8.653 MOUSE MYELOMA CELLS. HUMAN CONSTANT REGIONS INTRODUCED BY HOMOLOGOUS RECOMBINATION. CL IS HUMAN KAPPA, CH1 IS HUMAN IGG1 DOMAIN. 断片: CL AND CH1 / 器官: SPLEEN / Cell (発現宿主): SPLEEN, MYELOMA / 発現宿主: ![]() ![]() |
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#2: 抗体 | 分子量: 23609.449 Da / 分子数: 1 断片: MOUSE VH AND VL DOMAINS, HUMAN CL KAPPA AND CH1 IGG1 DOMAINS 由来タイプ: 組換発現 / 由来: (組換発現) ![]() 解説: MOUSE/HUMAN CHIMERA. MOUSE HYBRIDOMA PRODUCED BY FUSIONING BALB/C SPLEEN CELLS WITH 2X63-AG 8.653 MOUSE MYELOMA CELLS. HUMAN CONSTANT REGIONS INTRODUCED BY HOMOLOGOUS RECOMBINATION. CL IS ...解説: MOUSE/HUMAN CHIMERA. MOUSE HYBRIDOMA PRODUCED BY FUSIONING BALB/C SPLEEN CELLS WITH 2X63-AG 8.653 MOUSE MYELOMA CELLS. HUMAN CONSTANT REGIONS INTRODUCED BY HOMOLOGOUS RECOMBINATION. CL IS HUMAN KAPPA, CH1 IS HUMAN IGG1 DOMAIN. 断片: CL AND CH1 / 器官: SPLEEN / Cell (発現宿主): SPLEEN, MYELOMA / 発現宿主: ![]() ![]() |
#3: 化合物 | ChemComp-SO4 / |
#4: 水 | ChemComp-HOH / |
Has protein modification | Y |
配列の詳細 | THE FAB LIGHT CHAIN (RESIDUES 1 - 214) HAS BEEN ASSIGNED CHAIN INDICATOR L. THE FAB HEAVY CHAIN ...THE FAB LIGHT CHAIN (RESIDUES 1 - 214) HAS BEEN ASSIGNED CHAIN INDICATOR L. THE FAB HEAVY CHAIN (RESIDUES 1 - 227) HAS BEEN ASSIGNED CHAIN INDICATOR H. THE FAB FRAGMENT IS NUMBERED BY THE CONVENTION |
-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.4 Å3/Da / 溶媒含有率: 49 % | |||||||||||||||
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結晶化 | pH: 4.6 詳細: 0.1 M SODIUM ACETATE (PH 4.6), 0.1 M AMMONIUM SULFATE, 15 % PEG 8000. | |||||||||||||||
結晶化 | *PLUS pH: 7 / 手法: unknown | |||||||||||||||
溶液の組成 | *PLUS
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-データ収集
回折 | 平均測定温度: 295 K |
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放射光源 | 由来: ![]() |
検出器 | タイプ: SIEMENS-NICOLET X100 / 検出器: AREA DETECTOR / 日付: 1993年3月1日 / 詳細: MIRROR |
放射 | 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1.5418 Å / 相対比: 1 |
反射 | 解像度: 2.5→36 Å / Num. obs: 14826 / % possible obs: 87 % / Observed criterion σ(I): 0 / 冗長度: 2 % / Rmerge(I) obs: 0.045 / Net I/σ(I): 16.1 |
反射 シェル | 解像度: 2.5→2.8 Å / 冗長度: 1.5 % / Rmerge(I) obs: 0.107 / Mean I/σ(I) obs: 4 / % possible all: 65 |
反射 | *PLUS Num. measured all: 29571 |
反射 シェル | *PLUS 最高解像度: 2.53 Å / 最低解像度: 2.8 Å / % possible obs: 65 % |
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解析
ソフトウェア |
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精密化 | 構造決定の手法: ![]() 開始モデル: FV OF 1CLZ WITH CDRS REMOVED 1CLY (HUMAN IGG1, HUMAN KAPPA) AND OF 1CLZ (MOUSE IGG3, MOUSE KAPPA) 解像度: 2.5→8 Å / 交差検証法: EX POST FACTO / σ(F): 1
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原子変位パラメータ | Biso mean: 29 Å2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine analyze | Luzzati coordinate error obs: 0.28 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 2.5→8 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶媒の処理 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
原子変位パラメータ | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
拘束条件 | *PLUS
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