Entry Database : PDB / ID : 1shz Structure visualization Downloads & linksTitle Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera ComponentsGuanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera Rho guanine nucleotide exchange factor 1 DetailsKeywords SIGNALING PROTEIN / SIGNAL TRANSDUCTION / PROTEIN COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
D5 dopamine receptor binding / CDC42 GTPase cycle / regulation of fibroblast migration / Thromboxane signalling through TP receptor / NRAGE signals death through JNK / Thrombin signalling through proteinase activated receptors (PARs) / RAC1 GTPase cycle / Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / G alpha (12/13) signalling events ... D5 dopamine receptor binding / CDC42 GTPase cycle / regulation of fibroblast migration / Thromboxane signalling through TP receptor / NRAGE signals death through JNK / Thrombin signalling through proteinase activated receptors (PARs) / RAC1 GTPase cycle / Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / G alpha (12/13) signalling events / negative regulation of vascular associated smooth muscle cell migration / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / GTPase activating protein binding / negative regulation of synaptic transmission / G alpha (i) signalling events / regulation of small GTPase mediated signal transduction / branching involved in blood vessel morphogenesis / RHOB GTPase cycle / NRAGE signals death through JNK / RHOC GTPase cycle / negative regulation of vascular associated smooth muscle cell proliferation / Rho protein signal transduction / RHOA GTPase cycle / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / GTPase activator activity / guanyl-nucleotide exchange factor activity / G protein-coupled receptor binding / brush border membrane / G-protein beta/gamma-subunit complex binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / platelet activation / regulation of blood pressure / GDP binding / heterotrimeric G-protein complex / G alpha (12/13) signalling events / melanosome / cell cortex / regulation of cell shape / midbody / positive regulation of cytosolic calcium ion concentration / angiogenesis / in utero embryonic development / cell differentiation / intracellular signal transduction / cell cycle / G protein-coupled receptor signaling pathway / cell division / GTPase activity / centrosome / GTP binding / magnesium ion binding / protein-containing complex / RNA binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function p115RhoGEF, RGS domain / G-protein alpha subunit, group 12/13 / Regulator of G protein signalling-like domain / Regulator of G protein signalling-like domain / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / ARHGEF1-like, PH domain / PH domain / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like ... p115RhoGEF, RGS domain / G-protein alpha subunit, group 12/13 / Regulator of G protein signalling-like domain / Regulator of G protein signalling-like domain / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / ARHGEF1-like, PH domain / PH domain / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / RGS, subdomain 2 / RGS domain superfamily / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / G-protein alpha subunit, group I / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(i) subunit alpha-1 / Guanine nucleotide-binding protein subunit alpha-13 / Rho guanine nucleotide exchange factor 1 Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.85 Å DetailsAuthors Chen, Z. / Singer, W.D. / Sternweis, P.C. / Sprang, S.R. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2005Title : Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.Authors : Chen, Z. / Singer, W.D. / Sternweis, P.C. / Sprang, S.R. History Deposition Feb 26, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 18, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Aug 2, 2017 Group : Source and taxonomy / Category : entity_src_genRevision 1.4 Aug 23, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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