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- PDB-1pfn: PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1pfn | ||||||
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Title | PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 16-27 OF A 27-MODEL SET. | ||||||
![]() | PF4-M2 CHIMERA | ||||||
![]() | CYTOKINE | ||||||
Function / homology | ![]() CXCR3 chemokine receptor binding / CXCR chemokine receptor binding / negative regulation of MHC class II biosynthetic process / positive regulation of macrophage differentiation / killing by host of symbiont cells / positive regulation of macrophage derived foam cell differentiation / chemokine-mediated signaling pathway / leukocyte chemotaxis / Chemokine receptors bind chemokines / chemokine activity ...CXCR3 chemokine receptor binding / CXCR chemokine receptor binding / negative regulation of MHC class II biosynthetic process / positive regulation of macrophage differentiation / killing by host of symbiont cells / positive regulation of macrophage derived foam cell differentiation / chemokine-mediated signaling pathway / leukocyte chemotaxis / Chemokine receptors bind chemokines / chemokine activity / defense response to protozoan / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of megakaryocyte differentiation / Common Pathway of Fibrin Clot Formation / negative regulation of angiogenesis / neutrophil chemotaxis / platelet alpha granule lumen / Cell surface interactions at the vascular wall / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / adenylate cyclase-activating G protein-coupled receptor signaling pathway / platelet activation / cytokine-mediated signaling pathway / antimicrobial humoral immune response mediated by antimicrobial peptide / positive regulation of tumor necrosis factor production / Platelet degranulation / heparin binding / regulation of cell population proliferation / G alpha (i) signalling events / cellular response to lipopolysaccharide / collagen-containing extracellular matrix / inflammatory response / positive regulation of gene expression / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Mayo, K.H. / Roongta, V. / Ilyina, E. / Milius, R. / Barker, S. / Quinlan, C. / La Rosa, G. / Daly, T.J. | ||||||
![]() | ![]() Title: NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Authors: Mayo, K.H. / Roongta, V. / Ilyina, E. / Milius, R. / Barker, S. / Quinlan, C. / La Rosa, G. / Daly, T.J. #1: ![]() Title: Crystal Structure of Recombinant Human Platelet Factor 4 Authors: Zhang, X. / Chen, L. / Bancroft, D.P. / Lai, C.K. / Maione, T.E. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 1.2 MB | Display | ![]() |
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PDB format | ![]() | 1 MB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 387.6 KB | Display | ![]() |
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Full document | ![]() | 785.9 KB | Display | |
Data in XML | ![]() | 80.8 KB | Display | |
Data in CIF | ![]() | 115.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 7628.229 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other |
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Processing
Software |
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NMR software | Name: ![]() | ||||||||
NMR ensemble | Conformers submitted total number: 12 |