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Yorodumi- PDB-1pfm: PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1pfm | ||||||
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Title | PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 1-15 OF A 27-MODEL SET. | ||||||
Components | PF4-M2 CHIMERA | ||||||
Keywords | CYTOKINE | ||||||
Function / homology | Function and homology information CXCR3 chemokine receptor binding / negative regulation of megakaryocyte differentiation / CXCR chemokine receptor binding / negative regulation of MHC class II biosynthetic process / killing by host of symbiont cells / positive regulation of macrophage differentiation / positive regulation of macrophage derived foam cell differentiation / chemokine-mediated signaling pathway / leukocyte chemotaxis / Chemokine receptors bind chemokines ...CXCR3 chemokine receptor binding / negative regulation of megakaryocyte differentiation / CXCR chemokine receptor binding / negative regulation of MHC class II biosynthetic process / killing by host of symbiont cells / positive regulation of macrophage differentiation / positive regulation of macrophage derived foam cell differentiation / chemokine-mediated signaling pathway / leukocyte chemotaxis / Chemokine receptors bind chemokines / chemokine activity / defense response to protozoan / monocyte chemotaxis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of angiogenesis / Common Pathway of Fibrin Clot Formation / neutrophil chemotaxis / platelet alpha granule lumen / Cell surface interactions at the vascular wall / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / adenylate cyclase-activating G protein-coupled receptor signaling pathway / platelet activation / cytokine-mediated signaling pathway / positive regulation of tumor necrosis factor production / antimicrobial humoral immune response mediated by antimicrobial peptide / Platelet degranulation / heparin binding / regulation of cell population proliferation / G alpha (i) signalling events / cellular response to lipopolysaccharide / collagen-containing extracellular matrix / inflammatory response / positive regulation of gene expression / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Mayo, K.H. / Roongta, V. / Ilyina, E. / Milius, R. / Barker, S. / Quinlan, C. / La Rosa, G. / Daly, T.J. | ||||||
Citation | Journal: Biochemistry / Year: 1995 Title: NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Authors: Mayo, K.H. / Roongta, V. / Ilyina, E. / Milius, R. / Barker, S. / Quinlan, C. / La Rosa, G. / Daly, T.J. #1: Journal: Biochemistry / Year: 1994 Title: Crystal Structure of Recombinant Human Platelet Factor 4 Authors: Zhang, X. / Chen, L. / Bancroft, D.P. / Lai, C.K. / Maione, T.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1pfm.cif.gz | 1.5 MB | Display | PDBx/mmCIF format |
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PDB format | pdb1pfm.ent.gz | 1.3 MB | Display | PDB format |
PDBx/mmJSON format | 1pfm.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1pfm_validation.pdf.gz | 388.4 KB | Display | wwPDB validaton report |
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Full document | 1pfm_full_validation.pdf.gz | 879.1 KB | Display | |
Data in XML | 1pfm_validation.xml.gz | 101.6 KB | Display | |
Data in CIF | 1pfm_validation.cif.gz | 145.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pf/1pfm ftp://data.pdbj.org/pub/pdb/validation_reports/pf/1pfm | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 7628.229 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line: BL21 / Plasmid: BL21 / Production host: Escherichia coli (E. coli) / References: UniProt: P02776 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 15 |