- PDB-1oip: The Molecular Basis of Vitamin E Retention: Structure of Human Al... -
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基本情報
登録情報
データベース: PDB / ID: 1oip
タイトル
The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein
要素
ALPHA-TOCOPHEROL TRANSFER PROTEIN
キーワード
TRANSPORT / ATAXIA / AVED / TRANSFER PROTEIN / TOCOPHEROL / VITAMIN E TRANSPORT / DISEASE MUTATION
機能・相同性
機能・相同性情報
Vitamin E / vitamin E binding / vitamin E metabolic process / lipid transfer activity / vitamin transport / intermembrane lipid transfer / negative regulation of establishment of blood-brain barrier / positive regulation of amyloid-beta clearance / phosphatidylinositol-3,4-bisphosphate binding / phosphatidylinositol bisphosphate binding ...Vitamin E / vitamin E binding / vitamin E metabolic process / lipid transfer activity / vitamin transport / intermembrane lipid transfer / negative regulation of establishment of blood-brain barrier / positive regulation of amyloid-beta clearance / phosphatidylinositol-3,4-bisphosphate binding / phosphatidylinositol bisphosphate binding / embryonic placenta development / phosphatidylinositol-4,5-bisphosphate binding / lipid metabolic process / response to toxic substance / late endosome / cytosol 類似検索 - 分子機能
Alpha-tocopherol transfer / N-terminal domain of phosphatidylinositol transfer protein sec14p / Phosphatidylinositol Transfer Protein Sec14p / CRAL-TRIO lipid binding domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain superfamily / CRAL/TRIO domain / CRAL-TRIO lipid binding domain profile. ...Alpha-tocopherol transfer / N-terminal domain of phosphatidylinositol transfer protein sec14p / Phosphatidylinositol Transfer Protein Sec14p / CRAL-TRIO lipid binding domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain / CRAL/TRIO, N-terminal domain superfamily / CRAL/TRIO domain / CRAL-TRIO lipid binding domain profile. / Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) / CRAL-TRIO lipid binding domain / CRAL-TRIO lipid binding domain superfamily / Helicase, Ruva Protein; domain 3 / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Up-down Bundle / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
Chem-VIV / Alpha-tocopherol transfer protein 類似検索 - 構成要素
FUNCTION: BINDS ALPHA-TOCOPHEROL AND ENHANCES ITS TRANSFER BETWEEN SEPARATE MEMBRANES. DISEASE: ...FUNCTION: BINDS ALPHA-TOCOPHEROL AND ENHANCES ITS TRANSFER BETWEEN SEPARATE MEMBRANES. DISEASE: DEFECTS IN TTPA ARE THE CAUSE OF ATAXIA WITH ISOLATED VITAMIN E DEFICIENCY
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実験情報
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実験
実験
手法: X線回折 / 使用した結晶の数: 1
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試料調製
結晶
マシュー密度: 3.06 Å3/Da / 溶媒含有率: 59.75 %
結晶化
pH: 5.6 / 詳細: 12% PEG 6000, 0.1 M NA-CITRATE PH 5.6, 0.1 M LISO4