+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1ikm | ||||||
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タイトル | NMR study of monomeric human interleukin-8 (30 structures) | ||||||
要素 | HUMAN INTERLEUKIN-8 (MONOMERIC) | ||||||
キーワード | CYTOKINE (CHEMOTACTIC) | ||||||
機能・相同性 | 機能・相同性情報 regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / : / negative regulation of cell adhesion molecule production / CXCR chemokine receptor binding / ATF4 activates genes in response to endoplasmic reticulum stress / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis ...regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / : / negative regulation of cell adhesion molecule production / CXCR chemokine receptor binding / ATF4 activates genes in response to endoplasmic reticulum stress / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis / cellular response to fibroblast growth factor stimulus / chemokine-mediated signaling pathway / positive regulation of neutrophil chemotaxis / Chemokine receptors bind chemokines / chemokine activity / negative regulation of G protein-coupled receptor signaling pathway / Interleukin-10 signaling / cellular response to interleukin-1 / regulation of cell adhesion / neutrophil chemotaxis / response to endoplasmic reticulum stress / Peptide ligand-binding receptors / calcium-mediated signaling / response to molecule of bacterial origin / receptor internalization / positive regulation of angiogenesis / chemotaxis / antimicrobial humoral immune response mediated by antimicrobial peptide / cellular response to tumor necrosis factor / heparin binding / G alpha (i) signalling events / Senescence-Associated Secretory Phenotype (SASP) / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / angiogenesis / intracellular signal transduction / inflammatory response / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / negative regulation of gene expression / positive regulation of gene expression / signal transduction / extracellular space / extracellular region 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Rajarathnam, K. / Clark-Lewis, I. / Sykes, B.D. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1995 タイトル: 1H NMR solution structure of an active monomeric interleukin-8. 著者: Rajarathnam, K. / Clark-Lewis, I. / Sykes, B.D. #1: ジャーナル: Science / 年: 1994 タイトル: Neutrophil Activation by Monomeric Interleukin-8 著者: Rajarathnam, K. / Sykes, B.D. / Kay, C.M. / Dewald, B. / Geiser, T. / Baggiolini, M. / Clark-Lewis, I. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1ikm.cif.gz | 757 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1ikm.ent.gz | 641.9 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1ikm.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 1ikm_validation.pdf.gz | 363.2 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 1ikm_full_validation.pdf.gz | 561.2 KB | 表示 | |
XML形式データ | 1ikm_validation.xml.gz | 40.4 KB | 表示 | |
CIF形式データ | 1ikm_validation.cif.gz | 64.1 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ik/1ikm ftp://data.pdbj.org/pub/pdb/validation_reports/ik/1ikm | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 8415.832 Da / 分子数: 1 変異: DEL(1-3), THE AMIDE PROTON OF LEU 25 MODIFIED TO N-METHYL 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 参照: UniProt: P10145 |
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Has protein modification | Y |
-実験情報
-実験
実験 | 手法: 溶液NMR |
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-試料調製
結晶化 | *PLUS 手法: other / 詳細: NMR |
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-解析
ソフトウェア |
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NMR software | 名称: X-PLOR / 開発者: BRUNGER / 分類: 精密化 | ||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 30 |