+
データを開く
-
基本情報
| 登録情報 | データベース: PDB / ID: 1ikm | ||||||
|---|---|---|---|---|---|---|---|
| タイトル | NMR study of monomeric human interleukin-8 (30 structures) | ||||||
要素 | HUMAN INTERLEUKIN-8 (MONOMERIC) | ||||||
キーワード | CYTOKINE (CHEMOTACTIC) | ||||||
| 機能・相同性 | 機能・相同性情報regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / negative regulation of cell adhesion molecule production / ATF4 activates genes in response to endoplasmic reticulum stress / CXCR chemokine receptor binding / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis / positive regulation of neutrophil chemotaxis ...regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / negative regulation of cell adhesion molecule production / ATF4 activates genes in response to endoplasmic reticulum stress / CXCR chemokine receptor binding / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis / positive regulation of neutrophil chemotaxis / chemokine activity / Chemokine receptors bind chemokines / negative regulation of G protein-coupled receptor signaling pathway / Interleukin-10 signaling / cellular response to interleukin-1 / regulation of cell adhesion / neutrophil chemotaxis / cellular response to fibroblast growth factor stimulus / response to endoplasmic reticulum stress / Peptide ligand-binding receptors / calcium-mediated signaling / response to molecule of bacterial origin / receptor internalization / cellular response to tumor necrosis factor / chemotaxis / positive regulation of angiogenesis / antimicrobial humoral immune response mediated by antimicrobial peptide / heparin binding / cellular response to lipopolysaccharide / Senescence-Associated Secretory Phenotype (SASP) / Interleukin-4 and Interleukin-13 signaling / angiogenesis / G alpha (i) signalling events / intracellular signal transduction / G protein-coupled receptor signaling pathway / inflammatory response / negative regulation of cell population proliferation / negative regulation of gene expression / positive regulation of gene expression / signal transduction / : / extracellular region / membrane 類似検索 - 分子機能 | ||||||
| 生物種 | Homo sapiens (ヒト) | ||||||
| 手法 | 溶液NMR | ||||||
データ登録者 | Rajarathnam, K. / Clark-Lewis, I. / Sykes, B.D. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1995タイトル: 1H NMR solution structure of an active monomeric interleukin-8. 著者: Rajarathnam, K. / Clark-Lewis, I. / Sykes, B.D. #1: ジャーナル: Science / 年: 1994タイトル: Neutrophil Activation by Monomeric Interleukin-8 著者: Rajarathnam, K. / Sykes, B.D. / Kay, C.M. / Dewald, B. / Geiser, T. / Baggiolini, M. / Clark-Lewis, I. | ||||||
| 履歴 |
|
-
構造の表示
| 構造ビューア | 分子: Molmil Jmol/JSmol |
|---|
-
ダウンロードとリンク
-
ダウンロード
| PDBx/mmCIF形式 | 1ikm.cif.gz | 757 KB | 表示 | PDBx/mmCIF形式 |
|---|---|---|---|---|
| PDB形式 | pdb1ikm.ent.gz | 641.9 KB | 表示 | PDB形式 |
| PDBx/mmJSON形式 | 1ikm.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
| その他 | その他のダウンロード |
-検証レポート
| アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ik/1ikm ftp://data.pdbj.org/pub/pdb/validation_reports/ik/1ikm | HTTPS FTP |
|---|
-関連構造データ
-
リンク
-
集合体
| 登録構造単位 | ![]()
| |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
| |||||||||
| NMR アンサンブル |
|
-
要素
| #1: タンパク質 | 分子量: 8415.832 Da / 分子数: 1 変異: DEL(1-3), THE AMIDE PROTON OF LEU 25 MODIFIED TO N-METHYL 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 参照: UniProt: P10145 |
|---|---|
| Has protein modification | Y |
-実験情報
-実験
| 実験 | 手法: 溶液NMR |
|---|
-
試料調製
| 結晶化 | *PLUS 手法: other / 詳細: NMR |
|---|
-
解析
| ソフトウェア |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| NMR software | 名称: X-PLOR / 開発者: BRUNGER / 分類: 精密化 | ||||||||
| NMRアンサンブル | 登録したコンフォーマーの数: 30 |
ムービー
コントローラー
万見について




Homo sapiens (ヒト)
引用










PDBj







X-PLOR