Entry Database : PDB / ID : 1iij Structure visualization Downloads & linksTitle SOLUTION STRUCTURE OF THE NEU/ERBB-2 MEMBRANE SPANNING SEGMENT ComponentsERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE Details Keywords SIGNALING PROTEIN / alpha-helix-pi-bulge-alpha-helixFunction / homology Function and homology informationFunction Domain/homology Component
Signaling by ERBB2 / GRB7 events in ERBB2 signaling / ERBB2 Activates PTK6 Signaling / Drug-mediated inhibition of ERBB2 signaling / GRB2 events in ERBB2 signaling / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / Downregulation of ERBB2:ERBB3 signaling / Downregulation of ERBB2 signaling / Sema4D induced cell migration and growth-cone collapse ... Signaling by ERBB2 / GRB7 events in ERBB2 signaling / ERBB2 Activates PTK6 Signaling / Drug-mediated inhibition of ERBB2 signaling / GRB2 events in ERBB2 signaling / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / Downregulation of ERBB2:ERBB3 signaling / Downregulation of ERBB2 signaling / Sema4D induced cell migration and growth-cone collapse / SHC1 events in ERBB2 signaling / PIP3 activates AKT signaling / negative regulation of immature T cell proliferation in thymus / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / ERBB3:ERBB2 complex / ERBB2-ERBB4 signaling pathway / mammary gland involution / immature T cell proliferation in thymus / RNA polymerase I core binding / lateral loop / glial cell differentiation / sympathetic nervous system development / peripheral nervous system development / regulation of microtubule-based process / ErbB-3 class receptor binding / semaphorin receptor complex / positive regulation of Ras protein signal transduction / motor neuron axon guidance / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / tongue development / neuromuscular junction development / ERBB2-EGFR signaling pathway / positive regulation of Rho protein signal transduction / positive regulation of transcription by RNA polymerase I / ERBB2-ERBB3 signaling pathway / oligodendrocyte differentiation / regulation of cell differentiation / microvillus / semaphorin-plexin signaling pathway / positive regulation of cell adhesion / estrous cycle / response to axon injury / positive regulation of protein targeting to membrane / coreceptor activity / Schwann cell development / skeletal muscle tissue development / cellular response to epidermal growth factor stimulus / cell surface receptor protein tyrosine kinase signaling pathway / myelination / transmembrane receptor protein tyrosine kinase activity / phosphatidylinositol 3-kinase/protein kinase B signal transduction / neurogenesis / regulation of ERK1 and ERK2 cascade / basal plasma membrane / liver development / positive regulation of epithelial cell proliferation / response to progesterone / positive regulation of translation / wound healing / Hsp90 protein binding / neuromuscular junction / neuron differentiation / receptor protein-tyrosine kinase / receptor tyrosine kinase binding / cellular response to growth factor stimulus / ruffle membrane / transmembrane signaling receptor activity / myelin sheath / presynaptic membrane / nervous system development / heart development / regulation of cell population proliferation / cytoplasmic vesicle / positive regulation of cell growth / basolateral plasma membrane / postsynaptic membrane / protein tyrosine kinase activity / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell surface receptor signaling pathway / early endosome / receptor complex / endosome membrane / intracellular signal transduction / response to xenobiotic stimulus / positive regulation of protein phosphorylation / apical plasma membrane / protein heterodimerization activity / phosphorylation / signaling receptor binding / ubiquitin protein ligase binding / positive regulation of cell population proliferation / positive regulation of gene expression / protein-containing complex binding / negative regulation of apoptotic process / perinuclear region of cytoplasm / signal transduction / DNA binding / ATP binding Similarity search - Function : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain ... : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyMethod SOLUTION NMR / molecular dynamics DetailsAuthors Goetz, M. / Carlotti, C. / Bontems, F. / Dufourc, E.J. CitationJournal : Biochemistry / Year : 2001Title : Evidence for an alpha-helix --> pi-bulge helicity modulation for the neu/erbB-2 membrane-spanning segment. A 1H NMR and circular dichroism study.Authors : Goetz, M. / Carlotti, C. / Bontems, F. / Dufourc, E.J. History Deposition Apr 23, 2001 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 27, 2001 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 23, 2022 Group : Data collection / Database references / Derived calculationsCategory : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model Revision 1.4 May 22, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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