regulation of synaptic vesicle docking / HSF1-dependent transactivation / glutamatergic postsynaptic density / Interferon gamma signaling / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / peptidyl-threonine autophosphorylation / RAF activation / regulation of endocannabinoid signaling pathway / neurotransmitter receptor transport to plasma membrane ...regulation of synaptic vesicle docking / HSF1-dependent transactivation / glutamatergic postsynaptic density / Interferon gamma signaling / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / peptidyl-threonine autophosphorylation / RAF activation / regulation of endocannabinoid signaling pathway / neurotransmitter receptor transport to plasma membrane / : / calcium- and calmodulin-dependent protein kinase complex / Trafficking of AMPA receptors / Ca2+ pathway / RAF/MAP kinase cascade / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / regulation of neuron migration / dendritic spine development / calcium-dependent protein serine/threonine kinase activity / Ion homeostasis / positive regulation of calcium ion transport / negative regulation of hydrolase activity / postsynaptic neurotransmitter receptor diffusion trapping / presynaptic cytosol / GTPase activating protein binding / dendrite morphogenesis / postsynaptic specialization membrane / NMDA selective glutamate receptor signaling pathway / regulation of mitochondrial membrane permeability involved in apoptotic process / calcium/calmodulin-dependent protein kinase activity / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / postsynaptic cytosol / positive regulation of cardiac muscle cell apoptotic process / regulation of neuronal synaptic plasticity / cellular response to interferon-beta / regulation of protein localization to plasma membrane / glutamate receptor binding / dendrite cytoplasm / ionotropic glutamate receptor signaling pathway / response to ischemia / positive regulation of receptor signaling pathway via JAK-STAT / Schaffer collateral - CA1 synapse / G1/S transition of mitotic cell cycle / calcium ion transport / peptidyl-serine phosphorylation / dendritic spine / calmodulin binding / postsynaptic density / neuron projection / axon / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / glutamatergic synapse / synapse / dendrite / mitochondrion / ATP binding / metal ion binding / cytoplasm Similarity search - Function
Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / Nuclear Transport Factor 2; Chain: A, - #50 / NTF2-like domain superfamily / Nuclear Transport Factor 2; Chain: A, / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / Nuclear Transport Factor 2; Chain: A, - #50 / NTF2-like domain superfamily / Nuclear Transport Factor 2; Chain: A, / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Roll / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta Similarity search - Domain/homology
2,3-DIHYDROXY-1,4-DITHIOBUTANE / HEXATANTALUM DODECABROMIDE / Calcium/calmodulin-dependent protein kinase type II subunit alpha Similarity search - Component
Biological species
MUS MUSCULUS (house mouse)
Method
X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution: 2.65 Å
#89 - May 2007 Aconitase and Iron Regulatory Protein 1 similarity (1)
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Assembly
Deposited unit
A: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN B: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN C: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN D: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN E: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN F: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN G: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN H: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN I: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN J: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN K: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN L: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN M: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN N: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN hetero molecules
Mass: 18.015 Da / Num. of mol.: 62 / Source method: isolated from a natural source / Formula: H2O
Compound details
THIS KINASE MAY PLAY A ROLE IN NEUROTRANSMISSION. CATALYES ATP + PROTEIN = ADP + O-PHOSPHOPROTEIN. ...THIS KINASE MAY PLAY A ROLE IN NEUROTRANSMISSION. CATALYES ATP + PROTEIN = ADP + O-PHOSPHOPROTEIN. AUTOPHOSPHORYLATION OF THR-286 MAY ALLOW THE KINASE TO SWITCH FROM A CALMODULIN-DEPENDENT TO A CALMODULIN- INDEPENDENT STATE.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 4
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