+Open data
-Basic information
Entry | Database: PDB / ID: 1hgu | ||||||
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Title | HUMAN GROWTH HORMONE | ||||||
Components | HUMAN GROWTH HORMONE | ||||||
Keywords | HORMONE | ||||||
Function / homology | Function and homology information growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / animal organ development / cell surface receptor signaling pathway via STAT / positive regulation of multicellular organism growth / positive regulation of D-glucose transmembrane transport / positive regulation of insulin-like growth factor receptor signaling pathway ...growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / animal organ development / cell surface receptor signaling pathway via STAT / positive regulation of multicellular organism growth / positive regulation of D-glucose transmembrane transport / positive regulation of insulin-like growth factor receptor signaling pathway / growth hormone receptor binding / growth hormone receptor signaling pathway / Prolactin receptor signaling / cell surface receptor signaling pathway via JAK-STAT / Synthesis, secretion, and deacylation of Ghrelin / growth hormone receptor signaling pathway via JAK-STAT / positive regulation of tyrosine phosphorylation of STAT protein / Growth hormone receptor signaling / response to nutrient levels / cytokine activity / endosome lumen / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / positive regulation of MAP kinase activity / hormone activity / cytokine-mediated signaling pathway / response to estradiol / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / extracellular space / extracellular region / metal ion binding Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.5 Å | ||||||
Authors | Chantalat, L. / Jones, N. / Korber, F. / Navaza, J. / Pavlovsky, A.G. | ||||||
Citation | Journal: Protein Pept.Lett. / Year: 1995 Title: THE CRYSTAL-STRUCTURE OF WILD-TYPE GROWTH-HORMONE AT 2.5 ANGSTROM RESOLUTION. Authors: Chantalat, L. / Jones, N.D. / Korber, F. / Navaza, J. / Pavlovsky, A.G. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1hgu.cif.gz | 48.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1hgu.ent.gz | 38.7 KB | Display | PDB format |
PDBx/mmJSON format | 1hgu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1hgu_validation.pdf.gz | 396.4 KB | Display | wwPDB validaton report |
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Full document | 1hgu_full_validation.pdf.gz | 424.6 KB | Display | |
Data in XML | 1hgu_validation.xml.gz | 9.7 KB | Display | |
Data in CIF | 1hgu_validation.cif.gz | 13 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hg/1hgu ftp://data.pdbj.org/pub/pdb/validation_reports/hg/1hgu | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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Atom site foot note | 1: CIS PROLINE - PRO 37 2: ALA 67 - GLN 68 OMEGA = 215.88 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 3: GLN 68 - GLN 69 OMEGA = 226.17 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 4: ASP 107 - SER 108 OMEGA = 238.99 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 5: SER 108 - ASP 109 OMEGA = 269.60 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 6: ASN 149 - SER 150 OMEGA = 137.02 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 7: ASP 153 - ASP 154 OMEGA = 141.53 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION |
-Components
#1: Protein | Mass: 21902.771 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P01241 |
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#2: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 2.41 Å3/Da / Density % sol: 49.04 % | |||||||||||||||||||||||||
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Crystal grow | *PLUS pH: 7 / Method: vapor diffusion, hanging drop | |||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Wavelength: 1.5418 |
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Detector | Type: SIEMENS / Detector: AREA DETECTOR |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Rmerge(I) obs: 0.0747 |
Reflection | *PLUS Highest resolution: 2.5 Å / Lowest resolution: 15 Å / Num. obs: 5364 / % possible obs: 66.6 % / Num. measured all: 13055 / Rmerge(I) obs: 0.0747 |
Reflection shell | *PLUS Highest resolution: 2.5 Å / Lowest resolution: 2.75 Å / % possible obs: 37.1 % |
-Processing
Software |
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Refinement | Rfactor Rwork: 0.212 / Rfactor obs: 0.212 / Highest resolution: 2.5 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 34 Å2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine analyze | Luzzati coordinate error obs: 0.32 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Highest resolution: 2.5 Å
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Refine LS restraints |
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Software | *PLUS Name: X-PLOR/PROLSQ / Classification: refinement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Lowest resolution: 8 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
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