- PDB-1d2z: THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAIN... -
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Entry
Database: PDB / ID: 1d2z
Title
THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE
Components
DEATH DOMAIN OF PELLE
DEATH DOMAIN OF TUBE
Keywords
APOPTOSIS / SIX-HELIX BUNDLE / LINEAR ARRAY OF DEATH DOMAINS / PLASTIC INTERFACES
Function / homology
Function and homology information
MyD88 dependent cascade initiated on endosome / determination of dorsal/ventral asymmetry / hemocyte proliferation / Formation of the trans-membrane 'signalling complex' / Adaptor protein complex binds to TL receptor at the plasma membrane / DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' / DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' / Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' / Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' / PLL kinase binds to TUB in the TL receptor 'signalling complex' ...MyD88 dependent cascade initiated on endosome / determination of dorsal/ventral asymmetry / hemocyte proliferation / Formation of the trans-membrane 'signalling complex' / Adaptor protein complex binds to TL receptor at the plasma membrane / DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' / DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' / Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' / Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' / PLL kinase binds to TUB in the TL receptor 'signalling complex' / positive regulation of antifungal peptide production / TAK1-dependent IKK and NF-kappa-B activation / activated TAK1 mediates p38 MAPK activation / IRAK1 recruits IKK complex / IRAK2 mediated activation of TAK1 complex / TRAF6-mediated induction of TAK1 complex within TLR4 complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / Interleukin-1 signaling / zygotic specification of dorsal/ventral axis / positive regulation of hippo signaling / larval somatic muscle development / histone H3T3 kinase activity / antifungal innate immune response / Toll signaling pathway / response to fungus / positive regulation of ubiquitin-dependent protein catabolic process / dorsal/ventral pattern formation / protein tyrosine kinase binding / cytoplasmic side of plasma membrane / cytokine-mediated signaling pathway / positive regulation of protein catabolic process / mitotic cell cycle / cellular response to lipopolysaccharide / protein autophosphorylation / non-specific serine/threonine protein kinase / intracellular signal transduction / protein domain specific binding / protein phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function
Tube, Death domain / Tube Death domain / Pelle, death domain / Death Domain, Fas / Death Domain, Fas / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily ...Tube, Death domain / Tube Death domain / Pelle, death domain / Death Domain, Fas / Death Domain, Fas / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Mass: 12446.343 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Production host: Escherichia coli (E. coli) Keywords: THE FIRST FOUR RESIDUES OBSERVED IN THE STRUCTURE ORIGINATE FROM CLONING ARTEFACT. References: UniProt: Q05652
#2: Protein
DEATHDOMAINOFTUBE
Mass: 17084.508 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Production host: Escherichia coli (E. coli) / References: UniProt: P22812
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