+Open data
-Basic information
Entry | Database: PDB / ID: 1c5g | ||||||
---|---|---|---|---|---|---|---|
Title | PLASMINOGEN ACTIVATOR INHIBITOR-1 | ||||||
Components | PLASMINOGEN ACTIVATOR INHIBITOR-1 | ||||||
Keywords | BLOOD CLOTTING / SERPIN / SERINE PROTEASE INHIBITOR / PLASMA / PLASMINOGEN ACTIVATION / GLYCOPROTEIN / POLYMORPHISM | ||||||
Function / homology | Function and homology information positive regulation of leukotriene production involved in inflammatory response / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of smooth muscle cell migration / peptidase inhibitor complex / negative regulation of vascular wound healing / negative regulation of wound healing / positive regulation of odontoblast differentiation / negative regulation of cell adhesion mediated by integrin / negative regulation of endopeptidase activity ...positive regulation of leukotriene production involved in inflammatory response / dentinogenesis / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of smooth muscle cell migration / peptidase inhibitor complex / negative regulation of vascular wound healing / negative regulation of wound healing / positive regulation of odontoblast differentiation / negative regulation of cell adhesion mediated by integrin / negative regulation of endopeptidase activity / regulation of signaling receptor activity / negative regulation of plasminogen activation / negative regulation of blood coagulation / positive regulation of monocyte chemotaxis / Dissolution of Fibrin Clot / replicative senescence / ECM proteoglycans / positive regulation of blood coagulation / negative regulation of fibrinolysis / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / serine protease inhibitor complex / fibrinolysis / BMAL1:CLOCK,NPAS2 activates circadian gene expression / platelet alpha granule lumen / negative regulation of cell migration / positive regulation of interleukin-8 production / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / serine-type endopeptidase inhibitor activity / positive regulation of receptor-mediated endocytosis / positive regulation of inflammatory response / positive regulation of angiogenesis / Platelet degranulation / cellular response to lipopolysaccharide / protease binding / angiogenesis / collagen-containing extracellular matrix / defense response to Gram-negative bacterium / signaling receptor binding / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.6 Å | ||||||
Authors | Goldsmith, E.J. | ||||||
Citation | Journal: Nat.Struct.Biol. / Year: 1995 Title: Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Authors: Tucker, H.M. / Mottonen, J. / Goldsmith, E.J. / Gerard, R.D. #1: Journal: Nature / Year: 1992 Title: Structural Basis of Latency in Plasminogen Activator Inhibitor-1 Authors: Mottenen, J. / Strand, A. / Symersky, J. / Sweet, R.M. / Danley, D.E. / Geoghegan, K.F. / Gerard, R.D. / Goldsmith, E.J. #2: Journal: Proteins / Year: 1991 Title: Preliminary X-Ray Analysis of Crystals of Plasminogen Activator Inhibitor-1 Authors: Goldsmith, E.J. / Sheng-Cheng, C. / Danley, D.E. / Gerard, R.D. / Geoghegan, K.F. / Mottenen, J. / Strand, A. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1c5g.cif.gz | 84.2 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1c5g.ent.gz | 64.7 KB | Display | PDB format |
PDBx/mmJSON format | 1c5g.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1c5g_validation.pdf.gz | 364.1 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1c5g_full_validation.pdf.gz | 373.2 KB | Display | |
Data in XML | 1c5g_validation.xml.gz | 9.5 KB | Display | |
Data in CIF | 1c5g_validation.cif.gz | 13.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/c5/1c5g ftp://data.pdbj.org/pub/pdb/validation_reports/c5/1c5g | HTTPS FTP |
-Related structure data
Related structure data | |
---|---|
Similar structure data |
-Links
-Assembly
Deposited unit |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
|
-Components
#1: Protein | Mass: 45109.816 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: LATENT FORM / Source: (gene. exp.) Homo sapiens (human) / Plasmid: PPAIST-7HS / Production host: Escherichia coli (E. coli) / References: UniProt: P05121 |
---|
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION / Number of used crystals: 1 |
---|
-Sample preparation
Crystal | Density Matthews: 2.5 Å3/Da / Density % sol: 54 % |
---|---|
Crystal grow | *PLUS Method: unknown |
-Data collection
Diffraction source | Source: SYNCHROTRON / Site: NSLS / Beamline: X12C / Wavelength: 1.54 |
---|---|
Detector | Type: XUONG-HAMLIN MULTIWIRE / Detector: AREA DETECTOR / Date: Jan 5, 1999 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54 Å / Relative weight: 1 |
-Processing
Software |
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Resolution: 2.6→6 Å / Data cutoff high absF: 2 Details: PEPTIDE GEOMETRY TO GIVE RAMACHANDRAN ET AL BBA 359:298 (1974); PEPTIDE TORSIONS FROM HAGLER ET AL JACS 98:4600 (1976); NONBONDED TERMS JORGENSEN JACS 103:3976; W/ RC1-4 = 1.80 EC1-4 = 0.1
| ||||||||||||||||||
Displacement parameters | Biso mean: 28.38 Å2 | ||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.6→6 Å
| ||||||||||||||||||
Xplor file | Serial no: 1 / Param file: PAR19X.PRO / Topol file: TOPH19X.PRO |