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- PDB-1bxl: STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE S... -
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Basic information
Entry | Database: PDB / ID: 1bxl | ||||||
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Title | STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE | ||||||
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![]() | COMPLEX (APOPTOSIS/PEPTIDE) / APOPTOSIS / ALTERNATIVE SPLICING / COMPLEX (APOPTOSIS-PEPTIDE) / COMPLEX (APOPTOSIS-PEPTIDE) complex | ||||||
Function / homology | ![]() Activation and oligomerization of BAK protein / response to mycotoxin / B cell negative selection / BAK complex / BH domain binding / apoptotic process involved in blood vessel morphogenesis / response to fungus / negative regulation of endoplasmic reticulum calcium ion concentration / limb morphogenesis / Release of apoptotic factors from the mitochondria ...Activation and oligomerization of BAK protein / response to mycotoxin / B cell negative selection / BAK complex / BH domain binding / apoptotic process involved in blood vessel morphogenesis / response to fungus / negative regulation of endoplasmic reticulum calcium ion concentration / limb morphogenesis / Release of apoptotic factors from the mitochondria / apoptotic process in bone marrow cell / post-embryonic camera-type eye morphogenesis / SARS-CoV-1-mediated effects on programmed cell death / endocrine pancreas development / The NLRP1 inflammasome / dendritic cell apoptotic process / dendritic cell proliferation / establishment or maintenance of transmembrane electrochemical gradient / positive regulation of mononuclear cell proliferation / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / B cell apoptotic process / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of execution phase of apoptosis / negative regulation of dendritic cell apoptotic process / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / activation of cysteine-type endopeptidase activity / endoplasmic reticulum calcium ion homeostasis / positive regulation of endoplasmic reticulum unfolded protein response / fertilization / regulation of mitochondrial membrane permeability / negative regulation of protein localization to plasma membrane / regulation of growth / calcium ion transport into cytosol / response to UV-C / fibroblast apoptotic process / mitochondrial fusion / Bcl-2 family protein complex / myeloid cell homeostasis / NFE2L2 regulating tumorigenic genes / positive regulation of calcium ion transport into cytosol / response to cycloheximide / porin activity / cellular response to alkaloid / STAT5 activation downstream of FLT3 ITD mutants / hepatocyte apoptotic process / pore complex / thymocyte apoptotic process / negative regulation of reproductive process / negative regulation of developmental process / negative regulation of release of cytochrome c from mitochondria / negative regulation of peptidyl-serine phosphorylation / BH3 domain binding / germ cell development / apoptotic mitochondrial changes / positive regulation of IRE1-mediated unfolded protein response / positive regulation of release of cytochrome c from mitochondria / vagina development / positive regulation of proteolysis / B cell homeostasis / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / cellular response to unfolded protein / ectopic germ cell programmed cell death / blood vessel remodeling / Pyroptosis / animal organ regeneration / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / ovarian follicle development / extrinsic apoptotic signaling pathway in absence of ligand / heat shock protein binding / negative regulation of autophagy / intrinsic apoptotic signaling pathway / release of cytochrome c from mitochondria / regulation of mitochondrial membrane potential / regulation of cytokinesis / epithelial cell proliferation / response to cytokine / establishment of localization in cell / response to gamma radiation / apoptotic signaling pathway / cellular response to amino acid stimulus / positive regulation of protein-containing complex assembly / response to hydrogen peroxide / response to organic cyclic compound / cellular response to gamma radiation / synaptic vesicle membrane / cellular response to mechanical stimulus / endocytosis / RAS processing / male gonad development / intrinsic apoptotic signaling pathway in response to DNA damage / cellular response to UV / protein-folding chaperone binding / spermatogenesis / nuclear membrane / Interleukin-4 and Interleukin-13 signaling Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Sattler, M. / Liang, H. / Nettesheim, D. / Meadows, R.P. / Harlan, J.E. / Eberstadt, M. / Yoon, H. / Shuker, S.B. / Chang, B.S. / Minn, A.J. ...Sattler, M. / Liang, H. / Nettesheim, D. / Meadows, R.P. / Harlan, J.E. / Eberstadt, M. / Yoon, H. / Shuker, S.B. / Chang, B.S. / Minn, A.J. / Thompson, C.B. / Fesik, S.W. | ||||||
![]() | ![]() Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Authors: Sattler, M. / Liang, H. / Nettesheim, D. / Meadows, R.P. / Harlan, J.E. / Eberstadt, M. / Yoon, H.S. / Shuker, S.B. / Chang, B.S. / Minn, A.J. / Thompson, C.B. / Fesik, S.W. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 78.6 KB | Display | ![]() |
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PDB format | ![]() | 60.2 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 250.7 KB | Display | ![]() |
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Full document | ![]() | 250.4 KB | Display | |
Data in XML | ![]() | 5.8 KB | Display | |
Data in CIF | ![]() | 7.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 24879.371 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() Gene (production host): HUMAN BCL-XL, RESIDUES 1-44, 85-205, DELETION MUTANT LACKING A FLEXIBLE LOOP (RESIDUES 45-84) AND THE C-TERMINAL HYDROPHOBIC REGION, WITH A C-TERMINAL HIS-TAG Production host: ![]() ![]() |
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#2: Protein/peptide | Mass: 1726.934 Da / Num. of mol.: 1 / Fragment: RESIDUES 572 - 587 OF BAK PROTEIN Source method: isolated from a genetically manipulated source References: UniProt: Q16611 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR details | Text: NMR SPECTRA WERE RECORDED ON 1-3 MM SOLUTIONS OF BCL-XL COMPLEXED WITH A BAK PEPTIDE IN 10 MM SODIUM PHOSPHATE BUFFER (PH 6.5) AT 303K. |
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Sample preparation
Sample conditions | Temperature: 303 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
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NMR software | Name: ![]() | ||||||||||||
NMR ensemble | Conformers submitted total number: 1 |