EMDB-9534: Architecture of mammalian respirasome

Basic information

• Entry: Database: EMDB / ID: EMD-9534
• Title: Architecture of mammalian respirasome

Sample

• Complex: Respirasome
  • Protein or peptide: x 63 types
  • Ligand: x 10 types

• Keywords: Respiratory / Respirasome / Mammalian / ELECTRON TRANSPORT / OXIDOREDUCTASE

Function / homology

Function:

Complex III assembly / Complex IV assembly / TP53 Regulates Metabolic Genes / Cytoprotection by HMOX1 / : / subthalamus development / pons development / mitochondrial respirasome assembly / cerebellar Purkinje cell layer development / Complex I biogenesis / Respiratory electron transport / pyramidal neuron development / Respiratory electron transport / respiratory chain complex IV / anterograde axonal transport / thalamus development / cellular response to oxygen levels / mesenchymal stem cell proliferation / respiratory chain complex / reproductive system development / gliogenesis / cytochrome-c oxidase / mesenchymal stem cell differentiation / circulatory system development / respiratory chain complex III / oxidative phosphorylation / quinol-cytochrome-c reductase / neural precursor cell proliferation / mitochondrial electron transport, cytochrome c to oxygen / oxygen sensor activity / quinol-cytochrome-c reductase activity / cytochrome-c oxidase activity / stem cell division / mitochondrial electron transport, ubiquinol to cytochrome c / Mitochondrial protein degradation / hypothalamus development / acyl binding / midbrain development / ubiquinone binding / acyl carrier activity / electron transport coupled proton transport / NADH:ubiquinone reductase (H+-translocating) / mitochondrial respiratory chain complex I assembly / mitochondrial electron transport, NADH to ubiquinone / respiratory chain complex I / NADH dehydrogenase (ubiquinone) activity / quinone binding / ATP synthesis coupled electron transport / enzyme regulator activity / regulation of mitochondrial membrane potential / axon cytoplasm / muscle contraction / reactive oxygen species metabolic process / aerobic respiration / central nervous system development / respiratory electron transport chain / hippocampus development / DNA damage response, signal transduction by p53 class mediator / kidney development / fatty acid metabolic process / electron transport chain / mitochondrial membrane / metalloendopeptidase activity / mitochondrial intermembrane space / 2 iron, 2 sulfur cluster binding / multicellular organism growth / NAD binding / cellular senescence / FMN binding / 4 iron, 4 sulfur cluster binding / gene expression / oxidoreductase activity / mitochondrial inner membrane / mitochondrial matrix / copper ion binding / ubiquitin protein ligase binding / heme binding / mitochondrion / proteolysis / nucleoplasm / metal ion binding / membrane

Domain/homology:

Protein MGARP / Protein MGARP, N-terminal / Mitochondria Localisation Sequence / Cytochrome b-c1 complex subunit 10 / Single alpha-helix domain superfamily / Ubiquinol-cytochrome C reductase complex, 6.4kD protein / Cytochrome c oxidase, subunit 8 / Mitochondrial cytochrome c oxidase subunit VIc/VIIs / Cytochrome c oxidase, subunit 8 superfamily / Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily / : / Cytochrome oxidase c subunit VIII / Cytochrome c oxidase subunit VIc / Cytochrome c oxidase subunit VIIa, metazoa / Cytochrome C oxidase, subunit VIIB / Cytochrome c oxidase subunit IV / Cytochrome C oxidase, subunit VIIB domain superfamily / Cytochrome c oxidase, subunit VIIa superfamily / Cytochrome C oxidase chain VIIB / Cytochrome c oxidase, subunit VIa, conserved site / Cytochrome c oxidase subunit VIa signature. / Cytochrome c oxidase, subunit VIa / Cytochrome c oxidase, subunit VIa superfamily / Cytochrome c oxidase subunit VIa / Ubiquinol-cytochrome c reductase 8kDa, N-terminal / Ubiquinol-cytochrome c reductase 8 kDa, N-terminal / Cytochrome c oxidase, subunit VIb / : / Cytochrome c oxidase subunit Vb, zinc binding region signature. / Cytochrome c oxidase subunit VIIc / Cytochrome c oxidase subunit IV family / Cytochrome c oxidase, subunit VIb superfamily / Cytochrome c oxidase subunit VIIc superfamily / Cytochrome c oxidase subunit IV superfamily / Cytochrome c oxidase subunit VIIc / Cytochrome c oxidase subunit IV / Cytochrome c oxidase subunit 2, C-terminal / Cytochrome oxidase c subunit VIb / Cytochrome c oxidase, subunit Va/VI / Cytochrome c oxidase, subunit Va/VI superfamily / Cytochrome c oxidase subunit Va / Cytochrome c oxidase subunit VII / Cytochrome c oxidase subunit VII / Globular protein, non-globular alpha/beta subunit / Cytochrome c oxidase, subunit Vb / Cytochrome c oxidase subunit Vb / Cytochrome c oxidase subunit Vb, zinc binding domain profile. / Cytochrome c oxidase, subunit II / Cytochrome c oxidase, subunit Vb superfamily / Cytochrome c oxidase subunit I domain / Cytochrome b-c1 complex, subunit 6 / Cytochrome C oxidase subunit II, transmembrane domain / Cytochrome C oxidase subunit II, transmembrane domain / Cytochrome oxidase subunit II transmembrane region profile. / Cytochrome b-c1 complex subunit 8 / UcrQ family / Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily / Cytochrome b-c1 complex subunit 8 superfamily / Cytochrome b-c1 complex subunit Rieske, transmembrane domain / Ubiquinol cytochrome reductase transmembrane region / Cytochrome b-c1 complex subunit 9 / Cytochrome b-c1 complex subunit 9 superfamily / Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like / Cytochrome c/quinol oxidase subunit II / Ubiquinol-cytochrome C reductase hinge domain / Ubiquinol-cytochrome C reductase hinge domain superfamily / Ubiquinol-cytochrome C reductase hinge protein / Cytochrome c1, transmembrane anchor, C-terminal / : / Cytochrome b / Cytochrome C oxidase subunit II, transmembrane domain superfamily / Copper centre Cu(A) / CO II and nitrous oxide reductase dinuclear copper centers signature. / Ubiquinol-cytochrome c reductase, iron-sulphur subunit / : / Cytochrome c oxidase, subunit I, copper-binding site / Heme-copper oxidase catalytic subunit, copper B binding region signature. / Cytochrome c oxidase-like, subunit I domain / Cytochrome oxidase subunit I profile. / Cytochrome c1 / Cytochrome C1 family / : / Cytochrome b/b6, C-terminal / Cytochrome b(C-terminal)/b6/petD / Cytochrome b/b6 C-terminal region profile. / Peptidase M16, zinc-binding site / Insulinase family, zinc-binding region signature. / Cytochrome c oxidase subunit I / Cytochrome c oxidase-like, subunit I superfamily / Cytochrome C and Quinol oxidase polypeptide I / Cytochrome b/b6, C-terminal domain superfamily / Cytochrome b/b6/petB / Cytochrome C oxidase subunit II, periplasmic domain / Cytochrome c oxidase subunit II-like C-terminal / Cytochrome oxidase subunit II copper A binding domain profile. / Tim17/Tim22/Tim23/Pmp24 family / NADH-ubiquinone oxidoreductase, subunit 10 / NADH-ubiquinone oxidoreductase subunit 10 / Rieske iron-sulphur protein, C-terminal / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Component:

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 / Mitochondria localized glutamic acid rich protein / NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 / Acyl carrier protein / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial / NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / : / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 / : / NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial / : / : / NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 / NADH-ubiquinone oxidoreductase chain 1 / NADH-ubiquinone oxidoreductase chain 2 / NADH-ubiquinone oxidoreductase chain 3 / NADH-ubiquinone oxidoreductase chain 4 / NADH-ubiquinone oxidoreductase chain 6 / Cytochrome c1, heme protein, mitochondrial / Cytochrome b-c1 complex subunit 6, mitochondrial / Cytochrome b-c1 complex subunit 9 / Cytochrome b / Cytochrome c oxidase subunit 1 / Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / Cytochrome c oxidase subunit 5A, mitochondrial / Cytochrome c oxidase subunit 5B, mitochondrial / Cytochrome c oxidase subunit 6B1 / Cytochrome c oxidase subunit 7C, mitochondrial / Cytochrome c oxidase subunit 6C / Cytochrome c oxidase subunit 7A1, mitochondrial / Cytochrome c oxidase subunit 6A2, mitochondrial / Cytochrome b-c1 complex subunit 10 / Cytochrome c oxidase subunit 8B, mitochondrial / Cytochrome c oxidase subunit 7B, mitochondrial / Cytochrome b-c1 complex subunit 8 / Cytochrome b-c1 complex subunit Rieske, mitochondrial / Cytochrome b-c1 complex subunit 2, mitochondrial / Cytochrome b-c1 complex subunit 1, mitochondrial / NADH-ubiquinone oxidoreductase chain 4L / Cytochrome c oxidase subunit 2 / NADH-ubiquinone oxidoreductase chain 5

• Biological species: Sus scrofa (pig) / Bos taurus (domestic cattle)
• Method: single particle reconstruction / cryo EM / Resolution: 5.4 Å
• Authors: Gu J / Wu M

Funding support

China, 2 items

Organization	Grant number	Country
National Natural Science Foundation of China	31030020 and 31170679	China
Ministry of Science and Technology	2012CB911101	China

• Citation: Journal: Nature / Year: 2016; Title: The architecture of the mammalian respirasome.; Authors: Jinke Gu / Meng Wu / Runyu Guo / Kaige Yan / Jianlin Lei / Ning Gao / Maojun Yang / ; Abstract: The respiratory chain complexes I, III and IV (CI, CIII and CIV) are present in the bacterial membrane or the inner mitochondrial membrane and have a role of transferring electrons and establishing the proton gradient for ATP synthesis by complex V. The respiratory chain complexes can assemble into supercomplexes (SCs), but their precise arrangement is unknown. Here we report a 5.4 Å cryo-electron microscopy structure of the major 1.7 megadalton SCI1III2IV1 respirasome purified from porcine heart. The CIII dimer and CIV bind at the same side of the L-shaped CI, with their transmembrane domains essentially aligned to form a transmembrane disk. Compared to free CI, the CI in the respirasome is more compact because of interactions with CIII and CIV. The NDUFA11 and NDUFB9 supernumerary subunits of CI contribute to the oligomerization of CI and CIII. The structure of the respirasome provides information on the precise arrangements of the respiratory chain complexes in mitochondria.

History

Deposition	Oct 31, 2016	-
Header (metadata) release	Apr 5, 2017	-
Map release	Apr 12, 2017	-
Update	Oct 9, 2024	-
Current status	Oct 9, 2024	Processing site: PDBj / Status: Released

Map

• File: Download / File: emd_9534.map.gz / Format: CCP4 / Size: 421.9 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 1.05296 Å

Density

Contour Level	By AUTHOR: 0.0216 / Movie #1: 0.0216
Minimum - Maximum	-0.04734845 - 0.11140665
Average (Standard dev.)	0.0005272059 (±0.003714595)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 480 480 480 Spacing 480 480 480
Cell	A=B=C: 505.4208 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	1.0529604166667	1.0529604166667	1.0529604166667
M x/y/z	480	480	480
origin x/y/z	0.000	0.000	0.000
length x/y/z	505.421	505.421	505.421
α/β/γ	90.000	90.000	90.000
MAP C/R/S	1	2	3
start NC/NR/NS	0	0	0
NC/NR/NS	480	480	480
D min/max/mean	-0.047	0.111	0.001

Supplemental data

Sample components

Entire : Respirasome

• Entire: Name: Respirasome

Components

• Complex: Respirasome
  • Protein or peptide: Cytochrome b-c1 complex subunit 1, mitochondrial
  • Protein or peptide: Cytochrome b-c1 complex subunit 2, mitochondrial
  • Protein or peptide: Cytochrome b
  • Protein or peptide: Cytochrome c1, heme protein, mitochondrial
  • Protein or peptide: Cytochrome b-c1 complex subunit Rieske, mitochondrial
  • Protein or peptide: Cytochrome b-c1 complex subunit 7
  • Protein or peptide: Cytochrome b-c1 complex subunit 8
  • Protein or peptide: Cytochrome b-c1 complex subunit 6, mitochondrial
  • Protein or peptide: Cytochrome b-c1 complex subunit Rieske, mitochondrial
  • Protein or peptide: Cytochrome b-c1 complex subunit 9
  • Protein or peptide: Cytochrome b-c1 complex subunit 10
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3
  • Protein or peptide: NADH-ubiquinone oxidoreductase 75 kDa subunit
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8
  • Protein or peptide: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  • Protein or peptide: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 1
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 2
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 3
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 4
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 4L
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 5
  • Protein or peptide: NADH-ubiquinone oxidoreductase chain 6
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
  • Protein or peptide: Acyl carrier protein
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5
  • Protein or peptide: Mitochondrial NADH dehydrogenase Fe-S protein 4
  • Protein or peptide: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 3
  • Protein or peptide: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 5A, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 5B, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 6A2, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 6B1
  • Protein or peptide: Cytochrome c oxidase subunit 6C
  • Protein or peptide: Cytochrome c oxidase subunit 7A1, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 7B, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 7C, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 8B, mitochondrial
  • Protein or peptide: Cytochrome c oxidase subunit 1
  • Protein or peptide: Cytochrome c oxidase subunit 2
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 subunit C2
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 subunit C1
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Protein or peptide: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
  • Ligand: PROTOPORPHYRIN IX CONTAINING FE
  • Ligand: HEME C
  • Ligand: FE2/S2 (INORGANIC) CLUSTER
  • Ligand: IRON/SULFUR CLUSTER
  • Ligand: FLAVIN MONONUCLEOTIDE
  • Ligand: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
  • Ligand: ZINC ION
  • Ligand: HEME-A
  • Ligand: COPPER (II) ION
  • Ligand: MAGNESIUM ION

Supramolecule #1: Respirasome

• Supramolecule: Name: Respirasome / type: complex / ID: 1 / Parent: 0 / Macromolecule list: all / Details: Mammalian, respirasome
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 1.7 MDa

Macromolecule #1: Cytochrome b-c1 complex subunit 1, mitochondrial

• Macromolecule: Name: Cytochrome b-c1 complex subunit 1, mitochondrial / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 49.266254 KDa

Sequence

String:

TATYAQALQS VPETQVSQLD NGLRVASEQS SQPTCTVGVW IDAGSRYESE KNNGAGYFVE HLAFKGTKNR PGNALEKEVE SMGAHLNAY STREHTAYYI KALSKDLPKA VELLADIVQN CSLEDSQIEK ERDVILQELQ ENDTSMRDVV FNYLHATAFQ G TPLAQSVE GPSENVRKLS RADLTEYLSR HYKAPRMVLA AAGGLEHRQL LDLAQKHFSG LSGTYDEDAV PTLSPCRFTG SQ ICHREDG LPLAHVAIAV EGPGWAHPDN VALQVANAII GHYDCTYGGG AHLSSPLASI AATNKLCQSF QTFNICYADT GLL GAHFVC DHMSIDDMMF VLQGQWMRLC TSATESEVLR GKNLLRNALV SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIA EVDAR VVREVCSKYF YDQCPAVAGF GPIEQLPDYN RIRSGMFWLR F

UniProtKB: Cytochrome b-c1 complex subunit 1, mitochondrial

Macromolecule #2: Cytochrome b-c1 complex subunit 2, mitochondrial

• Macromolecule: Name: Cytochrome b-c1 complex subunit 2, mitochondrial / type: protein_or_peptide / ID: 2 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 46.575469 KDa

Sequence

String:

SLKVAPKVKA TEAPAGVPPH PQDLEFTRLP NGLVIASLEN YAPASRIGLF IKAGSRYENS NNLGTSHLLR LASSLTTKGA SSFKITRGI EAVGGKLSVT STRENMAYTV ECLRDDVDIL MEFLLNVTTA PEFRRWEVAA LQPQLRIDKA VALQNPQAHV I ENLHAAAY RNALANSLYC PDYRIGKVTP VELHDYVQNH FTSARMALIG LGVSHPVLKQ VAEQFLNIRG GLGLSGAKAK YH GGEIREQ NGDSLVHAAL VAESAAIGSA EANAFSVLQH VLGAGPHVKR GSNATSSLYQ AVAKGVHQPF DVSAFNASYS DSG LFGFYT ISQAASAGDV IKAAYNQVKT IAQGNLSNPD VQAAKNKLKA GYLMSVESSE GFLDEVGSQA LAAGSYTPPS TVLQ QIDAV ADADVINAAK KFVSGRKSMA ASGNLGHTPF IDEL

UniProtKB: Cytochrome b-c1 complex subunit 2, mitochondrial

Macromolecule #3: Cytochrome b

• Macromolecule: Name: Cytochrome b / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 42.62034 KDa

Sequence

String:

MTNIRKSHPL MKIVNNAFID LPAPSNISSW WNFGSLLGIC LILQILTGLF LAMHYTSDTT TAFSSVTHIC RDVNYGWIIR YMHANGASM FFICLYMHVG RGLYYGSYTF LETWNIGVIL LLTVMATAFM GYVLPWGQMS FWGATVITNL LSAIPYIGTN L VEWIWGGF SVDKATLTRF FAFHFILPFI IMAIAMVHLL FLHETGSNNP TGISSDVDKI PFHPYYTIKD ILGALLLILA LM LLVLFAP DLLGDPDNYT PANPLNTPPH IKPEWYFLFA YAILRSIPNK LGGVLALAFS ILILALIPLL HTSKQRSMMF RPL SQCLFW ALVADLLTLT WIGGQPVEHP YITIGQLASV LYFLLILVLM PTAGTIENKL LKW

UniProtKB: Cytochrome b

Macromolecule #4: Cytochrome c1, heme protein, mitochondrial

• Macromolecule: Name: Cytochrome c1, heme protein, mitochondrial / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 27.323277 KDa

Sequence

String:

SDLELHPPSY PWSHRGLLSS LDHTSIRRGF QVYKQVCSSC HSMDYVAYRH LVGVCYTEDE AKALAEEVEV QDGPNEDGEM FMRPGKLSD YFPKPYPNPE AARAANNGAL PPDLSYIVRA RHGGEDYVFS LLTGYCEPPT GVSLREGLYF NPYFPGQAIG M APPIYNEV LEFDDGTPAT MSQVAKDVCT FLRWAAEPEH DHRKRMGLKM LLMMGLLLPL VYAMKRHKWS VLKSRKLAYR PP K

UniProtKB: Cytochrome c1, heme protein, mitochondrial

Macromolecule #5: Cytochrome b-c1 complex subunit Rieske, mitochondrial

• Macromolecule: Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial / type: protein_or_peptide / ID: 5 / Number of copies: 2 / Enantiomer: LEVO / EC number: quinol-cytochrome-c reductase
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 29.572814 KDa

Sequence

String:

MLSVAARSGP FAPVLSATSR GVAGALRPLV QAAVPATSES PVLDLKRSVL CRESLRGQAA GRPVVASVSL NVPASVRYSH TDIKVPDFS DYRRPEVLDS TKSSKESSEA RKGFSYLVTA TTTVGVAYAA KNVVSQFVSS MSASADVLAM SKIEIKLSDI P EGKNMAFK WRGKPLFVRH RTKKEIDQEA AVEVSQLRDP QHDLERVKKP EWVILIGVCT HLGCVPIANA GDFGGYYCPC HG SHYDASG RIRKGPAPLN LEVPSYEFTS DDMVIVG

Macromolecule #6: Cytochrome b-c1 complex subunit 7

• Macromolecule: Name: Cytochrome b-c1 complex subunit 7 / type: protein_or_peptide / ID: 6 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 13.37119 KDa

Sequence

String:

AGRPAVSASS RWLEGIRKWY YNAAGFNKLG LMRDDTIHEN DDVKEAIRRL PENLYDDRVF RIKRALDLSM RQQILPKEQW TKYEEDKSY LEPYLKEVIR ERKEREEWAK K

Macromolecule #7: Cytochrome b-c1 complex subunit 8

• Macromolecule: Name: Cytochrome b-c1 complex subunit 8 / type: protein_or_peptide / ID: 7 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 9.606027 KDa

Sequence

String:

GRQFGHLTRV RHVITYSLSP FEQRAFPHYF SKGIPNVLRR TRACILRVAP PFVAFYLVYT WGTQEFEKSK RKNPAAYEND R

UniProtKB: Cytochrome b-c1 complex subunit 8

Macromolecule #8: Cytochrome b-c1 complex subunit 6, mitochondrial

• Macromolecule: Name: Cytochrome b-c1 complex subunit 6, mitochondrial / type: protein_or_peptide / ID: 8 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 9.189116 KDa

Sequence

String:

GDPKEEEEEE EELVDPLTTV REQCEQLEKC VKARERLELC DERVSSRSQT EEDCTEELLD FLHARDHCVA HKLFNSLK

UniProtKB: Cytochrome b-c1 complex subunit 6, mitochondrial

Macromolecule #9: Cytochrome b-c1 complex subunit Rieske, mitochondrial

• Macromolecule: Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO / EC number: quinol-cytochrome-c reductase
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 7.964259 KDa

Sequence

String:

MLSVAARSGP FAPVLSATSR GVAGALRPLV QAAVPATSES PVLDLKRSVL CRESLRGQAA GRPLVASVSL NVPASVRY

UniProtKB: Cytochrome b-c1 complex subunit Rieske, mitochondrial

Macromolecule #10: Cytochrome b-c1 complex subunit 9

• Macromolecule: Name: Cytochrome b-c1 complex subunit 9 / type: protein_or_peptide / ID: 10 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 7.209311 KDa

Sequence

String:

VAPTLTARLY SLLFRRTSTF ALTIVVGALF FERAFDQGAD AIYEHINEGK LWKHIKHKYE NK

UniProtKB: Cytochrome b-c1 complex subunit 9

Macromolecule #11: Cytochrome b-c1 complex subunit 10

• Macromolecule: Name: Cytochrome b-c1 complex subunit 10 / type: protein_or_peptide / ID: 11 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 6.527604 KDa

Sequence

String:

MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING KFKKDD

UniProtKB: Cytochrome b-c1 complex subunit 10

Macromolecule #12: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 30.241416 KDa

Sequence

String:

MAAAAAARGC WRGLVGPAAV ARVSGRPSVL LLPVRKESAA ADTRPTIRPR NDVVHKQLSA FGQYVAEILP KYVQQVQVSC FNELEIFIH PDGVIPVLTF LRDHTNAQFK SLADLTAVDV PTRQNRFEIV YNLLSLRFNS RIRVKTYTDE LTPIESSVTV Y KAANWYER EIWDMFGVFF ANHPDLRRIL TDYGFEGHPF RKDFPLSGYV ELRYDDEVKR VVAEPVELAQ EFRKFDLNSP WE AFPAYRQ PPEDLKLEAG DKKPETK

UniProtKB: UNIPROTKB: F1SIF2

Macromolecule #13: NADH-ubiquinone oxidoreductase 75 kDa subunit

• Macromolecule: Name: NADH-ubiquinone oxidoreductase 75 kDa subunit / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 79.627398 KDa

Sequence

String:

MLRIPVTRAL IGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVV AACAMPVMKG WNILTNSEKS KKAREGVMEF LLANHPLDCP ICDQGGECDL QDQSMMFGSD RSRFLEGKRA V EDKNIGPL VKTIMTRCIQ CTRCIRFASE IAGVDDLGTT GRGNDMQVGT YIEKMFMSEL SGNIIDICPV GALTSKPYAF TA RPWETRK TESIDVMDAV GSNIVVSTRT GEVMRILPRM HEDINEEWIS DKTRFAYDGL KRQRLTQPMI RNEKGLLTYT TWE DALSRV AGMLQSFQGN DVAAIAGGLV DAEALVALKD LLNRVDSDSL CTEEVFPTAG AGTDLRSNYL LNTTIAGVEE ADVI LLVGT NPRFEAPLFN ARIRKSWLHN DLKVALIGSP VDLTYRYDHL GDSPKILQDI ASGNHPFSQI LKEAKKPMVV LGSSA LQRS DGTAILAAVS NIAQNIRLSS GVTGDWKVMN ILHRIASQVA ALDLGYKPGV EAIRKNPPKV LFLLGADGGC ITRQDL PKD CFIIYQGHHG DVGAPMADVI LPGAAYTEKS ATYVNTEGRA QQTKVAVTPP GLAREDWKII RALSEIAGMT LPYDTLD QV RSRLEEVSPN LVRYDDVEGA NYFQQANELS KLVNQQLLAD PLVPPQLTIK DFYMTDSISR ASQTMAKCVK AVTEGIQA V EEPSIC

UniProtKB: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Macromolecule #14: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 52.552301 KDa

Sequence

String:

MAALRALCSL RGVAAQVLRP GAGARLPIQP SRGARQWQPD VEWAEQFGGA VMYPTKETAH WKPPPWNDVD PPKDTLVSNL TLNFGPQHP AAHGVLRLVM ELSGEMVRKC DPHIGLLHRG TEKLIEYKTY LQALPYFDRL DYVSMMCNEQ AYSLAVEKLL N IQPPPRAQ WIRVLFGEIT RLLNHIMAVT THALDIGAMT PFFWMFEERE KMFEFYERVS GARMHAAYIR PGGVHQDLPL GL LDDIYEF SKNFSFRIDE LEEMLTNNRI WRNRTVDIGV VTAEDALNYG FSGVMLRGSG IQWDLRKTQP YDVYDQVEFD VPI GSRGDC YDRYLCRVEE MRQSLRIISQ CLNKMPPGEI KVDDAKVSPP KRAEMKTSME SLIHHFKLYT EGYQVPPGAT YTAI EAPKG EFGVYLVSDG SSRPYRCKIK APGFAHLAGL DKMSKGHMLA DVVAIIGTQD IVFGEVDR

UniProtKB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Macromolecule #15: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 23.777742 KDa

Sequence

String:

MAALAASGLL RPILALRSSM GAAVQVRFVH PSAATDSPSS SQPAVSQAGA VVSKPTTLPS SRGEYVVAKL DDLVNWARRS SLWPMTFGL ACCAVEMMHM AAPRYDMDRF GVVFRASPRQ SDVMIVAGTL TNKMAPALRK VYDQMPEPRY VVSMGSCANG G GYYHYSYS VVRGCDRIVP VDIYVPGCPP TAEALLYGIL QLQRKIKREK RLRIWYRR

UniProtKB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Macromolecule #16: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 23.893281 KDa

Sequence

String:

MRCLSTPMLL RALAQAQAAH AGHPSARTLH SSAVAATYKF VNMREPSMDM KSVTDRAAQT LLWTELVRGL GMTLSYLFRE PATINYPFE KGPLSPRFRG EHALRRYPSG EERCIACKLC EAVCPAQAIT IEAEPRADGS RRTTRYDIDM TKCIYCGFCQ E ACPVDAIV EGPNFEFSTE THEELLYNKE KLLNNGDKWE AEIAANIQAD YLYR

Macromolecule #17: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 50.637766 KDa

Sequence

String:

MLAARRLLGG SLPARVSVRF SGDTTAPKKT SFGSLKDEDR IFTNLYGRHD WRLKGAQSRG DWYKTKEILL KGPDWILGEV KTSGLRGRG GAGFPTGLKW SFMNKPSDGR PKYLVVNADE GEPGTCKDRE IIRHDPHKLV EGCLVGGRAM GARAAYIYIR G EFYNEASN LQVAIREAYE AGLIGKNACG SGYDFDVFVV RGAGAYICGE ETALIESIEG KQGKPRLKPP FPADVGVFGC PT TVANVET VAVSPTICRR GGAWFASFGR ERNSGTKLFN ISGHVNHPCT VEEEMSVPLK ELIEKHAGGV IGGWDNLLAV IPG GSSTPL IPKSVCETVL MDFDALVQAQ TGLGTAAVIV MDRSTDIVKA IARLIEFYKH ESCGQCTPCR EGVDWMNKVM ARFV KGDAR PAEIDSLWEI SKQIEGHTIC ALGDGAAWPV QGLIRHFRPE LEERMQQFAL QHQARQAAS

UniProtKB: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Macromolecule #18: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 27.439533 KDa

Sequence

String:

MFLTAALRAR ATGFTAQWGR HVRNLHKTAV QNGAGGALFV HRDTPENNPD TPFDFTPENY KRIEAIVKNY PEGHKAAAVL PVLDLAQRQ NGWLPISAMN KVAEILQVPP MRVYEVATFY TMYNRKPVGK YHIQVCTTTP CMLRNSDSIL EAIQKKLGIK V GETTPDKL FTLIEVECLG ACVNAPMVQI NDNYYEDLTP KDIEEIIDEL KAGKIPKPGP RSGRFSCEPA GGLTSLTEPP KG PGFGVQA GL

UniProtKB: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Macromolecule #19: NADH-ubiquinone oxidoreductase chain 1

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 1 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 35.66752 KDa

Sequence

String:

MFMINILSLI IPILLAVAFL TLVERKVLGY MQLRKGPNVV GPYGLLQPIA DALKLFTKEP LRPATSSISM FIIAPILALS LALTMWVPL PMPYPLINMN LGVLFMLAMS SLAVYSILWS GWASNSKYAL IGALRAVAQT ISYEVTLAII LLSVLLMNGS Y TLSTLITT QEHIWMIFTS WPLAMMWFIS TLAETNRAPF DLTEGESELV SGFNVEYAAG PFAMFFMAEY ANIIMMNAFT AI LFLGASH DPHTPELYTI NFVLKTLALT ITFLWIRASY PRFRYDQLMH LLWKSFLPLT LALCMWHISL PIMTASIPPQ S

UniProtKB: NADH-ubiquinone oxidoreductase chain 1

Macromolecule #20: NADH-ubiquinone oxidoreductase chain 2

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 2 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 39.077504 KDa

Sequence

String:

MNPIIYTTLI MTVMSGTMLV MISSHWLLIW IGFEMNLLAM IPVLMKNFNP RATEAATKYF LTQATASMML MMAIIINLLY SGQWTITKM FNPVAMTMMT MALAMKLGLS PFHFWVPEVT QGISLQAGLL LLTWQKLAPL SVLCQISQSI NPNLMLTMAM L SILIGGWG GLNQTQLRKI MAYSSIAHMG WMTAVLPYNT TMTILNLLIY ITMTLAMFML LIHSSATTTL SLSHTWNKMP VI TSLMMVT LLSMGGLPPL SGFMPKWMII QEMTKNESII MPTLMAMTAL LNLYFYMRLA YSSSLTMFPS TNNMKMKWQF EHT KQMKLL PTMIVLSTLV LPMTPALSSL N

UniProtKB: NADH-ubiquinone oxidoreductase chain 2

Macromolecule #21: NADH-ubiquinone oxidoreductase chain 3

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 3 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 12.998448 KDa

Sequence

String:

MNIMLTLLTN VTLASLLVLI AFWLPQLNAY SEKTSPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLEIA LLLPLPWASQ TNNLKTMLT MALFLLILLA ASLAYEWTQK GLEWAE

UniProtKB: NADH-ubiquinone oxidoreductase chain 3

Macromolecule #22: NADH-ubiquinone oxidoreductase chain 4

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 4 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 51.859387 KDa

Sequence

String:

MLKIIIPTTM LLPMTWMSKH NMIWINATVH SLLISLISLS LLNQLGENSL NFSLTFFSDS LSAPLLVLTT WLLPLMLMAS QSHLSKETT TRKKLYITML ILLQLFLIMT FTATELILFY ILFEATLVPT LIIITRWGNQ TERLNAGLYF LFYTLAGSLP L LVALVYIQ NTTGSLNFLI IHYWSHPLSN SWSNIFMWLA CIMAFMVKMP LYGLHLWLPK AHVEAPIAGS MVLAAVLLKL GG YGMMRIT TILNPLTNYM AYPFLMLSMW GMIMTSSICL RQTDLKSLIA YSSVSHMALV IVAIMIQTPW SFMGATALMI AHG LTSSML FCLANTNYER VHSRTMILAR GLQTLLPLMA TWWLMASLTN LALPPSINLI GELFIITASF SWSNITIILM GMNM MITAL YSLYMLITTQ RGKYTHHINN IKASFTRENA LMALHILPLL LLTLNPKMIL GPLY

UniProtKB: NADH-ubiquinone oxidoreductase chain 4

Macromolecule #23: NADH-ubiquinone oxidoreductase chain 4L

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 4L / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 10.827253 KDa

Sequence

String:

MPLVYMNIIM AFAIALAGLL MYRSHLMSSL LCLEGMMLSL FIMSTLIILN THFTLANMMP IILLVFAACE AALGLSLLVM VSNTYGTDY VQNLNLLQC

UniProtKB: NADH-ubiquinone oxidoreductase chain 4L

Macromolecule #24: NADH-ubiquinone oxidoreductase chain 5

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 5 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 68.6955 KDa

Sequence

String:

MNPFASLTLT TLIILTIPIM MSNSNIYKTN LYPNYVKTTV SYAFTLSLVP LLMFMHTGQE MIISNWHWMT LQTVELSLSF KMDYFSVMF IPVALFVTWS IMEFSMWYMH SDPFINRFFK YLVLFLITMM ILVTANNLFQ LFIGWEGVGI MSFLLIGWWH G RTDANTAA LQAILYNRIG DIGFVLSMAW FLTHSNAWDL QQIFMLNNEC PNMPLIGLLL AAAGKSAQFG LHPWLPSAME GP TPVSALL HSSTMVVAGV FLLIRFYPLM ETNKLVQTMT LCLGAITTLF TALCAITQND IKKIVAFSTS SQLGLMMVTI GIN QPHLAF LHICMHAFFK AMLFMCSGSI IHSLNDEQDI RKMGGLYKAM PFTTTALIIG SLALTGMPYL TGFYSKDLII EAVN MSYTN AWALLMTLIA TSLTAAYSTR IIFFAFLGKP RFPPLVLINE NNPLLINSIK RLLIGSIFAG FIISNNIPPM TVPNT TMPL YMKMTALIVT IMGFMLALEL NNTTYYLKFK YPSQTYKFSN MLGYYPSIMH RLPTYHNLSM SQKSASSLLD LIWLET ILP KTTSFIQMKM SIMVSNQKGL IKLYFLSFLI TIMISMTLFN YHE

UniProtKB: NADH-ubiquinone oxidoreductase chain 5

Macromolecule #25: NADH-ubiquinone oxidoreductase chain 6

• Macromolecule: Name: NADH-ubiquinone oxidoreductase chain 6 / type: protein_or_peptide / ID: 25 / Number of copies: 2 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 19.021332 KDa

Sequence

String:

MTMYIAFILS TIFVIGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY LGGMLVVFGY TTAMATEMYP EVWVSNKTV FGAFVSGLMM EFCMVYYALK EEEVEIIFKF NGLGDWVIYD TGDSGFFSEE AMGIAALYSY GTWLVIVTGW S LLIGVVVI MEITRGN

UniProtKB: NADH-ubiquinone oxidoreductase chain 6

Macromolecule #26: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 9.225567 KDa

Sequence

String:

MAGRIASFLK NAWAKEPVLV ASFAIGGLAI ILPSLSPYTN YAIRINRATP YNYPVPLRDD GNMPDVPSHP QDPQGPSLEW LKNL

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Macromolecule #27: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO / EC number: NADH:ubiquinone reductase (H+-translocating)
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 11.099798 KDa

Sequence

String:

MAAAAASRGI RAKLGLREIR IHLCQRSPGS QGVRDFIEKR YVELKKANPD LPILIRECSD VQPKLWARYA FGQEKNVSLN NFSADQVTR TLENVLSGKA

Macromolecule #28: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 12.506591 KDa

Sequence

String:

MPFFDVQKRL GLDLDRWMTI QSAEQPHKIP GRCHAFEKEW IECAHGIGGI RAEKECKIEF DDFVECLLRQ KTMKRLSAIK RQRDKLIKE GKYTPPPHHL GKEDPRP

UniProtKB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Macromolecule #29: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9; type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 42.606324 KDa

Sequence

String:

MAAAVHPRVV RAVPMSRSCL AAVATSVSYG PPQRQLHHAL IPHGKGGRSS VSGIVATVFG ATGFLGRYVV NHLGRMGSQV IVPYRCEPY DTMHLRPMGD LGQIIFMEWN GKDKDSIRKV VEHSNVVINL VGREWETKNF DFEDVFVKIP HAIAQVSKEA G VEKLIHIS HLNADIKSPS RYLRSKAVGE KEVRAAFPEA TIIKPSDIFG REDRFLNYFA SMRWFGGVPL ISLGKETVKQ PV YIVDVSK GIINAIKDPD AKGKTFAFVG PNRYLLFDLV QYIFAVAYRP FLPYPLPHFA YRWVGRLFEV SPFEPWTTRD KVE RVHMSD MTLPHLPGLE DLGIQATPLE LKAIEVLRRH RTYRWLTSEM EDVKPAKTVN I

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Macromolecule #30: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mi...

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; type: protein_or_peptide / ID: 30 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 40.476082 KDa

Sequence

String:

MALRLLRLAP ASASAVPRGL GAVAQRVGGI HTGAPCRLQY GPLAFVLGER TTRKLTETSK VITVDGNICS GKGRLAREIA EKLGLRHFP EAGIHYADST TGDGKPLDVQ LSGNCSLEKF YDDPKSNDGN SYRLQSWLYA SRLLQYADAL EHLLSTGQGV V LERSIYSD FVFLEAMYRQ GFIRKQCVEH YNEVKKVTAC EYLPPHVVVY VDVPVPEIQS RIQKKGNPHE MKITAAYLQD IE NAYKKTF LPEMSEKCEV LQYSAREAED AEKVVEDIEY LKCDKGPWPD QDDRTFHRLR MLVQNKLEVL NYTTIPVYLP EIT IGAHQS DRVFQKFTEL PGRKYSPGYN EDVGDKWIWL K

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Macromolecule #31: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 16.911611 KDa

Sequence

String:

MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMFAVGI GTLLFGYWSM MKWNRERRRL QIEDFEARIA LMPLFQAEKD RRVLQMLRE NLEEEAIIMK DVPDWKVGES VFHTTRWVTP MMGELYGLRT NEEILSATYG FIWYT

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Macromolecule #32: Acyl carrier protein

• Macromolecule: Name: Acyl carrier protein / type: protein_or_peptide / ID: 32 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 17.326223 KDa

Sequence

String:

MAARVLCACV RRLPAAFAPL PRIPTVVAAR PLSTTLFPTG AQARSRALQP ALVLAQAPGG VTQMCRRYSD APPLTLEAIK DRVLYVLKL YDKIDPEKLS VNSHFMKDLG LDSLDQVEII MAMEDEFGFE IPDIDAEKLM CPQEIVDYIA DKKDVYE

UniProtKB: Acyl carrier protein

Macromolecule #33: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5; type: protein_or_peptide / ID: 33 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 21.587006 KDa

Sequence

String:

MAAMSLLQRA SVTAVATLSR SRLGTRFGFG GFLTHGFPKT GAPVRHSGDH GKRLFIIKPS GFYDRRFLKL MRFYILLTGI PVAIGITLV NVFIGEAELA DIPEGYVPEH WEYFKHPISR WIARTFYDGP EKNYEKTMAI LQIEAEKAEL RLKELEVRRL M RARGDGPW YQYPTIDKAL IDHSPKTTPD N

UniProtKB: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Macromolecule #34: Mitochondrial NADH dehydrogenase Fe-S protein 4

• Macromolecule: Name: Mitochondrial NADH dehydrogenase Fe-S protein 4 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 19.7185 KDa

Sequence

String:

MAAVSMSVAL KQALWGRRAA AVGAVSVSKV PTRLLSTSTW KLAQDQTQDT QLIAVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQS GVNNTKKWKM EFDTRERWEN PLMGWSSTAD PLSNLVLTFS TKEDAVAFAE KNGWSFDVEE RKVPKPKSKS Y GANFSWNK RTRVSTK

UniProtKB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Macromolecule #35: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 13.34895 KDa

Sequence

String:

MAAVTFLRLL GRSGAGARNL LGGSRCFGVR TSPTGEKVTH TGQAYDDGDY RRVRFSDRQK EVNENFAIDL IAEQPVSEVG SRVISCDGG GGALGHPRVY INLDKETKTG TCGYCGLQFR QPHH

UniProtKB: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Macromolecule #36: Cytochrome c oxidase subunit 3

• Macromolecule: Name: Cytochrome c oxidase subunit 3 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 29.9436 KDa

Sequence

String:

MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIIS EVLFFTGFFW AFYHSSLAPT PELGGCWPPT GIHPLNPLEV PLLNTSVLLA SGVSITWAHH SLMEGDRKHM L QALFITIT LGVYFTLLQA SEYYEAPFTI SDGVYGSTFF VATGFHGLHV IIGSTFLIVC FFRQLKFHFT SNHHFGFEAG AW YWHFVDV VWLFLYVSIY WWGS

Macromolecule #37: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 17.179646 KDa

Sequence

String:

AHGSVVKSED YALPSYVDRR DYPLPDVAHV KNLSASQKAL KEKEKASWSS LSIDEKVELY RLKFKESFAE MNRSTNEWKT VVGAAMFFI GFTALLLIWE KHYVYGPIPH TFEEEWVAKQ TKRMLDMKVA PIQGFSAKWD YDKNEWKK

UniProtKB: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Macromolecule #38: Cytochrome c oxidase subunit 5A, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 5A, mitochondrial / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 12.453081 KDa

Sequence

String:

SHGSHETDEE FDARWVTYFN KPDIDAWELR KGMNTLVGYD LVPEPKIIDA ALRACRRLND FASAVRILEV VKDKAGPHKE IYPYVIQEL RPTLNELGIS TPEELGLDKV

UniProtKB: Cytochrome c oxidase subunit 5A, mitochondrial

Macromolecule #39: Cytochrome c oxidase subunit 5B, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 5B, mitochondrial / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 10.684038 KDa

Sequence

String:

ASGGGVPTDE EQATGLEREV MLAARKGQDP YNILAPKATS GTKEDPNLVP SITNKRIVGC ICEEDNSTVI WFWLHKGEAQ RCPSCGTHY KLVPHQLAH

UniProtKB: Cytochrome c oxidase subunit 5B, mitochondrial

Macromolecule #40: Cytochrome c oxidase subunit 6A2, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 6A2, mitochondrial / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 9.452687 KDa

Sequence

String:

ASAAKGDHGG TGARTWRFLT FGLALPSVAL CTLNSWLHSG HRERPAFIPY HHLRIRTKPF SWGDGNHTFF HNPRVNPLPT GYEK

UniProtKB: Cytochrome c oxidase subunit 6A2, mitochondrial

Macromolecule #41: Cytochrome c oxidase subunit 6B1

• Macromolecule: Name: Cytochrome c oxidase subunit 6B1 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 10.039244 KDa

Sequence

String:

AEDIQAKIKN YQTAPFDSRF PNQNQTRNCW QNYLDFHRCE KAMTAKGGDV SVCEWYRRVY KSLCPISWVS TWDDRRAEGT FPGKI

UniProtKB: Cytochrome c oxidase subunit 6B1

Macromolecule #42: Cytochrome c oxidase subunit 6C

• Macromolecule: Name: Cytochrome c oxidase subunit 6C / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 8.494982 KDa

Sequence

String:

STALAKPQMR GLLARRLRFH IVGAFMVSLG FATFYKFAVA EKRKKAYADF YRNYDSMKDF EEMRKAGIFQ SAK

UniProtKB: Cytochrome c oxidase subunit 6C

Macromolecule #43: Cytochrome c oxidase subunit 7A1, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 7A1, mitochondrial / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 6.682726 KDa

Sequence

String:

FENRVAEKQK LFQEDNGLPV HLKGGATDNI LYRVTMTLCL GGTLYSLYCL GWASFPHKK

UniProtKB: Cytochrome c oxidase subunit 7A1, mitochondrial

Macromolecule #44: Cytochrome c oxidase subunit 7B, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 7B, mitochondrial / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 6.365217 KDa

Sequence

String:

IHQKRAPDFH DKYGNAVLAS GATFCVAVWV YMATQIGIEW NPSPVGRVTP KEWREQ

UniProtKB: Cytochrome c oxidase subunit 7B, mitochondrial

Macromolecule #45: Cytochrome c oxidase subunit 7C, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 7C, mitochondrial / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 5.449396 KDa

Sequence

String:

SHYEEGPGKN IPFSVENKWR LLAMMTLFFG SGFAAPFFIV RHQLLKK

UniProtKB: Cytochrome c oxidase subunit 7C, mitochondrial

Macromolecule #46: Cytochrome c oxidase subunit 8B, mitochondrial

• Macromolecule: Name: Cytochrome c oxidase subunit 8B, mitochondrial / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 4.967756 KDa

Sequence

String:

ITAKPAKTPT SPKEQAIGLS VTFLSFLLPA GWVLYHLDNY KKSSAA

UniProtKB: Cytochrome c oxidase subunit 8B, mitochondrial

Macromolecule #47: Cytochrome c oxidase subunit 1

• Macromolecule: Name: Cytochrome c oxidase subunit 1 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO / EC number: cytochrome-c oxidase
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 57.065844 KDa

Sequence

String:

MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSMVE AGAGTGWTVY PPLAGNLAHA GASVDLTIFS LHLAGVSSIL G AINFITTI INMKPPAMSQ YQTPLFVWSV MITAVLLLLS LPVLAAGITM LLTDRNLNTT FFDPAGGGDP ILYQHLFWFF GH PEVYILI LPGFGMISHI VTYYSGKKEP FGYMGMVWAM MSIGFLGFIV WAHHMFTVGM DVDTRAYFTS ATMIIAIPTG VKV FSWLAT LHGGNIKWSP AMMWALGFIF LFTVGGLTGI VLANSSLDIV LHDTYYVVAH FHYVLSMGAV FAIMGGFVHW FPLF SGYTL NDTWAKIHFA IMFVGVNMTF FPQHFLGLSG MPRRYSDYPD AYTMWNTISS MGSFISLTAV MLMVFIIWEA FASKR EVLT VDLTTTNLEW LNGCPPPYHT FEEPTYVNLK

UniProtKB: Cytochrome c oxidase subunit 1

Macromolecule #48: Cytochrome c oxidase subunit 2

• Macromolecule: Name: Cytochrome c oxidase subunit 2 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Bos taurus (domestic cattle)
• Molecular weight: Theoretical: 26.040393 KDa

Sequence

String:

MAYPMQLGFQ DATSPIMEEL LHFHDHTLMI VFLISSLVLY IISLMLTTKL THTSTMDAQE VETIWTILPA IILILIALPS LRILYMMDE INNPSLTVKT MGHQWYWSYE YTDYEDLSFD SYMIPTSELK PGELRLLEVD NRVVLPMEMT IRMLVSSEDV L HSWAVPSL GLKTDAIPGR LNQTTLMSSR PGLYYGQCSE ICGSNHSFMP IVLELVPLKY FEKWSASML

UniProtKB: Cytochrome c oxidase subunit 2

Macromolecule #49: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 49 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 11.422071 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

Macromolecule #50: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 8.088424 KDa

Sequence

String:

MWFEILPGIA VMAACLFIPG MATAHIHKFT NGGKEKRVAH FSYQWNLMER DRRISGVNRY HVTKGLENID

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Macromolecule #51: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 51 / Number of copies: 4 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 3.677524 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)

Macromolecule #52: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 13.32159 KDa

Sequence

String:

MAGLLKKTTG LVGLAVCETP HERLKILYTK ILDVLGQIPK NAAYRKYTEQ ITNEKLGMVK AEPDVKKLEE QLQGGQIEEV ILQAENELS LARKMLRWKP WEPLVEEPPA NQWKWPI

UniProtKB: UNIPROTKB: F1SLY2

Macromolecule #53: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 14.953313 KDa

Sequence

String:

MAASGLPRAA AAAGTSVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHLF QLDISVKQGR DKVREMFMKN AHVTDPRVVD LLVIKGKME LEETINVWKQ RTHIMRFFHE TEAPRPTDFL SKFYVGHDP

UniProtKB: UNIPROTKB: F1SRG2

Macromolecule #54: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 14.686894 KDa

Sequence

String:

MAKTLLHKYS DIPEGTECHR KAYASTSIGG ATGLIVSAYS IALKPPASFL EGVARTGRYT FTSAAIGAIF GLTSCISAQV REKPDDPLN YFIGGCAGGL TLGARTRSYG IGAAACAYMG LTAALVKMGQ LEGWQVFAEP KV

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Macromolecule #55: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 20.944768 KDa

Sequence

String:

MPDSWDKDVY PEPPRRTPAP APQTSLPNPV TYLTKIFDLL VDRPVTLARE FIEQQHAKNR YYYYHREFRR VPDITECEEK DILCMFEAE MQWRRDYKVD QEIVNIIQER LKACQQREGE SYRQNCAKEL EQFTQVSKAF QDRYSDLGAH YSARKCLAKQ K QRMLAERK AAKEAAAA

UniProtKB: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Macromolecule #56: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 21.733711 KDa

Sequence

String:

MAFSAPAAYL THQQKVLRLY KRALRHLESW CVHRDKYRYF ACLMRARFDE HKNEKDMVKA TQLLRQAEEE FWYGQHPQPY IFPESPGGT SYERYECYKV PEWCLDDWHP SEKAMYPDYF AKREQWKRLR RESWEREVKQ LQEETPPGGP RTEALPPARK E GDLPPLWW HIVTRPRERP

UniProtKB: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Macromolecule #57: NADH dehydrogenase [ubiquinone] 1 subunit C2

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 subunit C2 / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 14.327655 KDa

Sequence

String:

MTMMSGRPGR VPLQFLPNEA RSLPPPKLTD PRLVYMGFLG YCSGLIDNAI RRRPVVSAGL HRQLLYVTSF VFFGYYLLKR QDYMYALRD HDMFAYVKSH PEDFPEKDKK TYGEILEEFH PVR

UniProtKB: UNIPROTKB: F1STY1

Macromolecule #58: NADH dehydrogenase [ubiquinone] 1 subunit C1

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 subunit C1 / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 8.630037 KDa

Sequence

String:

MAASALLRPF SKLLSSARLP SGSSARSKFY IREPPHGSPD WLKVGLTLGT SVFLWIYLIK QHKEDVLEYK RRNGLE

UniProtKB: Mitochondria localized glutamic acid rich protein

Macromolecule #59: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 20.064096 KDa

Sequence

String:

MPGIVELPTL EDLKVQEVKV SSSVLKAAAH HYGAQCDKPN KEFMLCRWEE KDPRRCLEEG KLVNQCALDF FRQIKRHCAE PFTEYWTCI DYSGLQLFRH CRKQQAKFDE CVLDKLGWVR PDLGELSKVT KVKTDRPLPE NPYHSRARPE PNPEAEGDLK P AKHGSRLF FWTM

UniProtKB: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Macromolecule #60: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 60 / Number of copies: 3 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 6.485986 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

Macromolecule #61: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 2.91158 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)

Macromolecule #62: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 1.464797 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)

Macromolecule #63: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment

• Macromolecule: Name: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment; type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Sus scrofa (pig)
• Molecular weight: Theoretical: 1.124378 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)

Macromolecule #64: PROTOPORPHYRIN IX CONTAINING FE

• Macromolecule: Name: PROTOPORPHYRIN IX CONTAINING FE / type: ligand / ID: 64 / Number of copies: 4 / Formula: HEM
• Molecular weight: Theoretical: 616.487 Da

Chemical component information

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

Macromolecule #65: HEME C

• Macromolecule: Name: HEME C / type: ligand / ID: 65 / Number of copies: 2 / Formula: HEC
• Molecular weight: Theoretical: 618.503 Da

Chemical component information

ChemComp-HEC:
HEME C

Macromolecule #66: FE2/S2 (INORGANIC) CLUSTER

• Macromolecule: Name: FE2/S2 (INORGANIC) CLUSTER / type: ligand / ID: 66 / Number of copies: 4 / Formula: FES
• Molecular weight: Theoretical: 175.82 Da

Chemical component information

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

Macromolecule #67: IRON/SULFUR CLUSTER

• Macromolecule: Name: IRON/SULFUR CLUSTER / type: ligand / ID: 67 / Number of copies: 6 / Formula: SF4
• Molecular weight: Theoretical: 351.64 Da

Chemical component information

ChemComp-FS1:
IRON/SULFUR CLUSTER

Macromolecule #68: FLAVIN MONONUCLEOTIDE

• Macromolecule: Name: FLAVIN MONONUCLEOTIDE / type: ligand / ID: 68 / Number of copies: 1 / Formula: FMN
• Molecular weight: Theoretical: 456.344 Da

Chemical component information

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

Macromolecule #69: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

• Macromolecule: Name: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE; type: ligand / ID: 69 / Number of copies: 1 / Formula: NDP
• Molecular weight: Theoretical: 745.421 Da

Chemical component information

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Macromolecule #70: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 70 / Number of copies: 1 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #71: HEME-A

• Macromolecule: Name: HEME-A / type: ligand / ID: 71 / Number of copies: 2 / Formula: HEA
• Molecular weight: Theoretical: 852.837 Da

Chemical component information

ChemComp-HEA:
HEME-A

Macromolecule #72: COPPER (II) ION

• Macromolecule: Name: COPPER (II) ION / type: ligand / ID: 72 / Number of copies: 3 / Formula: CU
• Molecular weight: Theoretical: 63.546 Da

Chemical component information

ChemComp-CU:
COPPER (II) ION

Macromolecule #73: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 73 / Number of copies: 1 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.2
• Grid: Model: Quantifoil R1.2/1.3 / Material: COPPER / Mesh: 400
• Vitrification: Cryogen name: NITROGEN

Electron microscopy

• Microscope: FEI TITAN KRIOS
• Image recording: Film or detector model: FEI FALCON II (4k x 4k) / Detector mode: COUNTING / Average electron dose: 1.7 e/Ų
• Electron beam: Acceleration voltage: 300 kV / Electron source: TUNGSTEN HAIRPIN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• Startup model: Type of model: OTHER
• Final reconstruction: Resolution.type: BY AUTHOR / Resolution: 5.4 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: EMAN (ver. 2.1) / Number images used: 139996
• Initial angle assignment: Type: ANGULAR RECONSTITUTION / Software - Name: EMAN (ver. 2.1)
• Final angle assignment: Type: ANGULAR RECONSTITUTION / Software - Name: EMAN (ver. 2.1)
• Final 3D classification: Software - Name: EMAN (ver. 2.1)

Atomic model buiding 1

• Refinement: Space: REAL / Protocol: RIGID BODY FIT

Output model

PDB-5gpn:
Architecture of mammalian respirasome