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- PDB-5gpn: Architecture of mammalian respirasome -

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Entry
Database: PDB / ID: 5gpn
TitleArchitecture of mammalian respirasome
Descriptorubiquinol-cytochrome c reductase core protein I
heme protein,mitochondrial
Uncharacterized protein
NDUFV2
(Cytochrome ...) x 21
(NADH-ubiquinone oxidoreductase ...) x 10
(NADH dehydrogenase [ubiquinone] ...) x 2
KeywordsELECTRON TRANSPORT / OXIDOREDUCTASE / Respiratory / Respirasome / Mammalian
Specimen sourceBos taurus / mammal / Bovine / ウシ /
Sus scrofa / mammal / Pig / イノシシ, いのしし, ニホンイノシシ, ブタ / image: Sus scrofa domestica
MethodElectron microscopy (5.4 A resolution / Single particle)
AuthorsGu, J. / Wu, M. / Guo, R. / Yang, M.
CitationNature, 2016, 537, 639-643

Nature, 2016, 537, 639-643 StrPapers
The architecture of the mammalian respirasome.
Jinke Gu / Meng Wu / Runyu Guo / Kaige Yan / Jianlin Lei / Ning Gao / Maojun Yang

DateDeposition: Aug 3, 2016 / Release: Apr 5, 2017 / Last modification: Apr 12, 2017

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Assembly

Deposited unit
A: Cytochrome b-c1 complex subunit 1, mitochondrial
B: Cytochrome b-c1 complex subunit 2, mitochondrial
C: Cytochrome b
D: Cytochrome c1, heme protein, mitochondrial
E: Cytochrome b-c1 complex subunit Rieske, mitochondrial
F: Cytochrome b-c1 complex subunit 7
G: Cytochrome b-c1 complex subunit 8
H: Cytochrome b-c1 complex subunit 6, mitochondrial
I: Cytochrome b-c1 complex subunit Rieske, mitochondrial
J: Cytochrome b-c1 complex subunit 9
K: Cytochrome b-c1 complex subunit 10
L: Cytochrome b-c1 complex subunit 9
M: Cytochrome b-c1 complex subunit 1, mitochondrial
N: Cytochrome b-c1 complex subunit 2, mitochondrial
O: Cytochrome b
P: Cytochrome c1, heme protein, mitochondrial
Q: Cytochrome b-c1 complex subunit Rieske, mitochondrial
R: Cytochrome b-c1 complex subunit 7
S: Cytochrome b-c1 complex subunit 8
T: Cytochrome b-c1 complex subunit 6, mitochondrial
U: Cytochrome b-c1 complex subunit Rieske, mitochondrial
V: Cytochrome b-c1 complex subunit 10
W: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3
Y: NADH-ubiquinone oxidoreductase 75 kDa subunit
Z: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2
a: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7
b: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8
c: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
d: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
e: NADH-ubiquinone oxidoreductase chain 1
f: NADH-ubiquinone oxidoreductase chain 2
g: NADH-ubiquinone oxidoreductase chain 3
h: NADH-ubiquinone oxidoreductase chain 4
i: NADH-ubiquinone oxidoreductase chain 4L
j: NADH-ubiquinone oxidoreductase chain 5
k: NADH-ubiquinone oxidoreductase chain 6
l: NADH-ubiquinone oxidoreductase chain 6
m: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
n: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
o: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
p: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9
q: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
r: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
t: Acyl carrier protein
u: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5
v: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
w: Mitochondrial NADH dehydrogenase Fe-S protein 4
x: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
0: Cytochrome c oxidase subunit 3
1: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
2: Cytochrome c oxidase subunit 5A, mitochondrial
3: Cytochrome c oxidase subunit 5B, mitochondrial
4: Cytochrome c oxidase subunit 6A2, mitochondrial
5: Cytochrome c oxidase subunit 6B1
6: Cytochrome c oxidase subunit 6C
7: Cytochrome c oxidase subunit 7A1, mitochondrial
8: Cytochrome c oxidase subunit 7B, mitochondrial
9: Cytochrome c oxidase subunit 7C, mitochondrial
s: Cytochrome c oxidase subunit 8B, mitochondrial
y: Cytochrome c oxidase subunit 1
z: Cytochrome c oxidase subunit 2
Aa: Acyl carrier protein
Ab: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Ac: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Ad: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Ae: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Af: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Ag: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Ah: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Ai: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5
Aj: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Ak: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Al: NADH dehydrogenase [ubiquinone] 1 subunit C2
Am: NADH dehydrogenase [ubiquinone] 1 subunit C1
An: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Ao: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Ap: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Aq: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Ar: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
As: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
At: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Au: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Av: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
Aw: NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment
hetero molecules


Theoretical massNumber of molelcules
Total (without water)1,741,771109
Polyers1,732,06784
Non-polymers9,70425
Water0
#1


  • idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551

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Components

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Cytochrome ... , 24 types, 35 molecules AMBNCODPEQ...

#1: Polypeptide(L)Cytochrome b-c1 complex subunit 1, mitochondrial


Mass: 49266.254 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P31800

Cellular component

Molecular function

Biological process

#2: Polypeptide(L)Cytochrome b-c1 complex subunit 2, mitochondrial / Complex III subunit 2 / Core protein II / Ubiquinol-cytochrome-c reductase complex core protein 2


Mass: 46575.469 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P23004

Cellular component

Molecular function

Biological process

  • oxidation-reduction process (GO: 0055114)
  • protein processing involved in protein targeting to mitochondrion (GO: 0006627)
#3: Polypeptide(L)Cytochrome b / Complex III subunit 3 / Complex III subunit III / Cytochrome b-c1 complex subunit 3 / Ubiquinol-cytochrome-c reductase complex cytochrome b subunit


Mass: 42620.340 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P00157

Cellular component

  • integral component of membrane (GO: 0016021)
  • integral component of mitochondrial inner membrane (GO: 0031305)
  • integral component of mitochondrial membrane (GO: 0032592)
  • intrinsic component of mitochondrial membrane (GO: 0098573)
  • mitochondrial respiratory chain complex III (GO: 0005750)

Molecular function

Biological process

  • mitochondrial electron transport, ubiquinol to cytochrome c (GO: 0006122)
  • respiratory electron transport chain (GO: 0022904)
#4: Polypeptide(L)Cytochrome c1, heme protein, mitochondrial / Complex III subunit 4 / Complex III subunit IV / Cytochrome b-c1 complex subunit 4 / Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit / Cytochrome c-1


Mass: 27323.277 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P00125

Cellular component

Molecular function

  • electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity (GO: 0045155)
  • electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity (GO: 0045153)
  • heme binding (GO: 0020037)
  • metal ion binding (GO: 0046872)

Biological process

  • mitochondrial ATP synthesis coupled proton transport (GO: 0042776)
  • mitochondrial electron transport, ubiquinol to cytochrome c (GO: 0006122)
#5: Polypeptide(L)Cytochrome b-c1 complex subunit Rieske, mitochondrial / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


Mass: 29572.814 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: EC: 1.10.2.2
#6: Polypeptide(L)Cytochrome b-c1 complex subunit 7 / Complex III subunit 7 / Complex III subunit VII / QP-C / Ubiquinol-cytochrome c reductase complex 14 kDa protein


Mass: 13371.190 Da / Num. of mol.: 2 / Source: (natural) Bos taurus
#7: Polypeptide(L)Cytochrome b-c1 complex subunit 8 / Complex III subunit 8 / Complex III subunit VIII / Ubiquinol-cytochrome c reductase complex 9.5 kDa protein / Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C


Mass: 9606.027 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P13271

Cellular component

  • mitochondrial respiratory chain complex III (GO: 0005750)

Molecular function

  • ubiquinol-cytochrome-c reductase activity (GO: 0008121)

Biological process

#8: Polypeptide(L)Cytochrome b-c1 complex subunit 6, mitochondrial / Complex III subunit 6 / Complex III subunit VIII / Cytochrome c1 non-heme 11 kDa protein / Mitochondrial hinge protein / Ubiquinol-cytochrome c reductase complex 11 kDa protein


Mass: 9189.116 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P00126

Cellular component

  • mitochondrial respiratory chain complex III (GO: 0005750)

Molecular function

  • ubiquinol-cytochrome-c reductase activity (GO: 0008121)

Biological process

#9: Polypeptide(L)Cytochrome b-c1 complex subunit Rieske, mitochondrial / Complex III subunit 5 / Cytochrome b-c1 complex subunit 5 / Rieske iron-sulfur protein / RISP / Ubiquinol-cytochrome c reductase iron-sulfur subunit


Mass: 7964.259 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P13272, EC: 1.10.2.2

Cellular component

Molecular function

#10: Polypeptide(L)Cytochrome b-c1 complex subunit 9 / Complex III subunit 9 / Complex III subunit X / Cytochrome c1 non-heme 7 kDa protein / Ubiquinol-cytochrome c reductase complex 7.2 kDa protein


Mass: 7209.311 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P00130

Cellular component

Biological process

  • aerobic respiration (GO: 0009060)
  • hydrogen ion transmembrane transport (GO: 1902600)
  • mitochondrial electron transport, ubiquinol to cytochrome c (GO: 0006122)
  • mitochondrial respiratory chain complex III assembly (GO: 0034551)
#11: Polypeptide(L)Cytochrome b-c1 complex subunit 10 / Complex III subunit 10 / Complex III subunit XI / Ubiquinol-cytochrome c reductase complex 6.4 kDa protein


Mass: 6527.604 Da / Num. of mol.: 2 / Source: (natural) Bos taurus / References: UniProt: P07552

Cellular component

Molecular function

#36: Polypeptide(L)Cytochrome c oxidase subunit 3 / Cytochrome c oxidase polypeptide III


Mass: 29943.600 Da / Num. of mol.: 1 / Source: (natural) Bos taurus
#37: Polypeptide(L)Cytochrome c oxidase subunit 4 isoform 1, mitochondrial / Cytochrome c oxidase polypeptide IV / Cytochrome c oxidase subunit IV isoform 1 / COX IV-1


Mass: 17179.646 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P00423

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, cytochrome c to oxygen (GO: 0006123)
#38: Polypeptide(L)Cytochrome c oxidase subunit 5A, mitochondrial


Mass: 12453.081 Da / Num. of mol.: 1 / Fragment: UNP RESIDUES 44-152 / Source: (natural) Bos taurus / References: UniProt: P00426

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, cytochrome c to oxygen (GO: 0006123)
#39: Polypeptide(L)Cytochrome c oxidase subunit 5B, mitochondrial / Cytochrome c oxidase polypeptide VIa / Cytochrome c oxidase polypeptide Vb


Mass: 10684.038 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P00428

Cellular component

Molecular function

Biological process

  • mitochondrial ATP synthesis coupled proton transport (GO: 0042776)
  • mitochondrial electron transport, cytochrome c to oxygen (GO: 0006123)
#40: Polypeptide(L)Cytochrome c oxidase subunit 6A2, mitochondrial / Cytochrome c oxidase polypeptide VIa-heart / COXVIAH / Cytochrome c oxidase polypeptide VIb


Mass: 9452.687 Da / Num. of mol.: 1 / Fragment: UNP RESIDUES 13-96 / Source: (natural) Bos taurus / References: UniProt: P07471

Cellular component

Molecular function

Biological process

#41: Polypeptide(L)Cytochrome c oxidase subunit 6B1 / Cytochrome c oxidase polypeptide VII / Cytochrome c oxidase subunit AED / Cytochrome c oxidase subunit VIb isoform 1 / COX VIb-1


Mass: 10039.244 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P00429

Cellular component

Molecular function

#42: Polypeptide(L)Cytochrome c oxidase subunit 6C / Cytochrome c oxidase polypeptide VIc / Cytochrome c oxidase subunit STA


Mass: 8494.982 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P04038

Cellular component

Molecular function

#43: Polypeptide(L)Cytochrome c oxidase subunit 7A1, mitochondrial / Cytochrome c oxidase subunit VIIIc / VIIIC / Cytochrome c oxidase subunit VIIa-heart / Cytochrome c oxidase subunit VIIa-H / Cytochrome c oxidase subunit VIIa-muscle / Cytochrome c oxidase subunit VIIa-M


Mass: 6682.726 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P07470

Cellular component

Molecular function

#44: Polypeptide(L)Cytochrome c oxidase subunit 7B, mitochondrial / Cytochrome c oxidase polypeptide VIIb / IHQ


Mass: 6365.217 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P13183

Cellular component

Molecular function

Biological process

#45: Polypeptide(L)Cytochrome c oxidase subunit 7C, mitochondrial / Cytochrome c oxidase polypeptide VIIIA / Cytochrome c oxidase polypeptide VIIc


Mass: 5449.396 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P00430

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, cytochrome c to oxygen (GO: 0006123)
#46: Polypeptide(L)Cytochrome c oxidase subunit 8B, mitochondrial / Cytochrome c oxidase polypeptide VIII-heart / Cytochrome c oxidase subunit 8-1 / Cytochrome c oxidase subunit 8H / IX / VIIIb


Mass: 4967.756 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P10175

Cellular component

Molecular function

Biological process

  • hydrogen ion transmembrane transport (GO: 1902600)
  • mitochondrial electron transport, cytochrome c to oxygen (GO: 0006123)
#47: Polypeptide(L)Cytochrome c oxidase subunit 1 / Cytochrome c oxidase polypeptide I


Mass: 57065.844 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P00396, EC: 1.9.3.1

Cellular component

Molecular function

Biological process

#48: Polypeptide(L)Cytochrome c oxidase subunit 2 / Cytochrome c oxidase polypeptide II


Mass: 26040.393 Da / Num. of mol.: 1 / Source: (natural) Bos taurus / References: UniProt: P68530

Cellular component

Molecular function

Biological process

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NADH dehydrogenase [ubiquinone] iron-sulfur protein ... , 6 types, 6 molecules WZabox

#12: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 3


Mass: 30241.416 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SIF2

Cellular component

Molecular function

Biological process

#14: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 2


Mass: 52552.301 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1S1A8

Cellular component

Molecular function

Biological process

  • mitochondrial ATP synthesis coupled electron transport (GO: 0042775)
  • response to oxidative stress (GO: 0006979)
#15: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 7


Mass: 23777.742 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: I3LK43

Molecular function

#16: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 8


Mass: 23893.281 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa
#28: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 5


Mass: 12506.591 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SV23

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

Biological process

  • mitochondrial respiratory chain complex I assembly (GO: 0032981)
#35: Polypeptide(L)NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial


Mass: 13348.950 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1S031

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

Biological process

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Polypeptide(L) , 3 types, 4 molecules YtAaw

#13: Polypeptide(L)NADH-ubiquinone oxidoreductase 75 kDa subunit


Mass: 79627.398 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SHD7

Cellular component

Molecular function

Biological process

#32: Polypeptide(L)Acyl carrier protein


Mass: 17326.223 Da / Num. of mol.: 2 / Source: (natural) Sus scrofa / References: UniProt: F1SAB6

Cellular component

Molecular function

  • ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process (GO: 0000036)
  • acyl binding (GO: 0000035)
  • phosphopantetheine binding (GO: 0031177)

Biological process

#34: Polypeptide(L)Mitochondrial NADH dehydrogenase Fe-S protein 4


Mass: 19718.500 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: G8IFA6

Molecular function

  • oxidoreductase activity, acting on NAD(P)H (GO: 0016651)

Biological process

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NADH dehydrogenase [ubiquinone] flavoprotein ... , 2 types, 2 molecules cd

#17: Polypeptide(L)NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


Mass: 50637.766 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1RVN1

Cellular component

Molecular function

Biological process

  • mitochondrial ATP synthesis coupled electron transport (GO: 0042775)
#18: Polypeptide(L)NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial


Mass: 27439.533 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SM98

Cellular component

Molecular function

Biological process

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NADH-ubiquinone oxidoreductase chain ... , 7 types, 8 molecules efghijkl

#19: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 1 / NADH dehydrogenase subunit 1


Mass: 35667.520 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: O79874, EC: 1.6.5.3

Cellular component

Molecular function

Biological process

#20: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 2 / NADH dehydrogenase subunit 2


Mass: 39077.504 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: O79875, EC: 1.6.5.3

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, NADH to ubiquinone (GO: 0006120)
#21: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 3 / NADH dehydrogenase subunit 3


Mass: 12998.448 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: O79880, EC: 1.6.5.3

Cellular component

Molecular function

#22: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 4 / NADH dehydrogenase subunit 4


Mass: 51859.387 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: O79881, EC: 1.6.5.3

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, NADH to ubiquinone (GO: 0006120)
#23: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 4L / NADH dehydrogenase subunit 4L


Mass: 10827.253 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: P56632, EC: 1.6.5.3

Cellular component

Molecular function

Biological process

#24: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 5 / NADH dehydrogenase subunit 5


Mass: 68695.500 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: Q9TDR1, EC: 1.6.5.3

Cellular component

Molecular function

Biological process

#25: Polypeptide(L)NADH-ubiquinone oxidoreductase chain 6 / NADH dehydrogenase subunit 6


Mass: 19021.332 Da / Num. of mol.: 2 / Source: (natural) Sus scrofa / References: UniProt: O79882, EC: 1.6.5.3

Cellular component

Molecular function

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit ... , 10 types, 11 molecules mnpqvrAcAeAfAgAn

#26: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3


Mass: 9225.567 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1RNI5

Cellular component

#27: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2


Mass: 11099.798 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: EC: 1.6.5.3
#29: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9


Mass: 42606.324 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SL07

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

Molecular function

Biological process

#30: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial


Mass: 40476.082 Da / Num. of mol.: 2 / Source: (natural) Sus scrofa / References: UniProt: F1SIS9

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, NADH to ubiquinone (GO: 0006120)
#31: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13


Mass: 16911.611 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1S6Q1

Cellular component

Molecular function

Biological process

  • cellular response to interferon-beta (GO: 0035458)
  • cellular response to retinoic acid (GO: 0071300)
  • extrinsic apoptotic signaling pathway (GO: 0097191)
  • negative regulation of cell growth (GO: 0030308)
  • negative regulation of intrinsic apoptotic signaling pathway (GO: 2001243)
  • negative regulation of transcription, DNA-templated (GO: 0045892)
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO: 0043280)
  • positive regulation of protein catabolic process (GO: 0045732)
  • protein import into mitochondrial inner membrane (GO: 0045039)
  • reactive oxygen species metabolic process (GO: 0072593)
#50: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1


Mass: 8088.424 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: K7GR43

Cellular component

#52: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5


Mass: 13321.590 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SLY2

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

Molecular function

Biological process

#53: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6


Mass: 14953.313 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SRG2

Cellular component

Biological process

#54: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11


Mass: 14686.894 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: I3LGM4

Cellular component

#59: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8


Mass: 20064.096 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1SLR1

Cellular component

Molecular function

Biological process

+
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit ... , 3 types, 4 molecules uAiAjAk

#33: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5


Mass: 21587.006 Da / Num. of mol.: 2 / Source: (natural) Sus scrofa / References: UniProt: F1SGC6

Cellular component

#55: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10


Mass: 20944.768 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: I3LDC3

Cellular component

#56: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9


Mass: 21733.711 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: K7GSE5

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

Biological process

  • mitochondrial electron transport, NADH to ubiquinone (GO: 0006120)

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NADH dehydrogenase [ubiquinone] 1 unknown subunit ... , 6 types, 12 molecules AbAhAdAoApAvAqAsAwArAtAu

#49: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 11422.071 Da / Num. of mol.: 2 / Source: (natural) Sus scrofa
#51: Polypeptide(L)
NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 3677.524 Da / Num. of mol.: 4 / Source: (natural) Sus scrofa
#60: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 6485.986 Da / Num. of mol.: 3 / Source: (natural) Sus scrofa
#61: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 2911.580 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa
#62: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 1464.797 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa
#63: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 unknown subunit fragment


Mass: 1124.378 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa

+
NADH dehydrogenase [ubiquinone] 1 subunit ... , 2 types, 2 molecules AlAm

#57: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 subunit C2


Mass: 14327.655 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1STY1

Cellular component

Molecular function

Biological process

  • mitochondrial electron transport, NADH to ubiquinone (GO: 0006120)
#58: Polypeptide(L)NADH dehydrogenase [ubiquinone] 1 subunit C1


Mass: 8630.037 Da / Num. of mol.: 1 / Source: (natural) Sus scrofa / References: UniProt: F1RRC9

Cellular component

  • mitochondrial respiratory chain complex I (GO: 0005747)

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Non-polymers , 10 types, 25 molecules

#64: Chemical
ChemComp-HEM / PROTOPORPHYRIN IX CONTAINING FE / HEME


Mass: 616.487 Da / Num. of mol.: 4 / Formula: C34H32FeN4O4
#65: ChemicalChemComp-HEC / HEME C


Mass: 618.503 Da / Num. of mol.: 2 / Formula: C34H34FeN4O4
#66: Chemical
ChemComp-FES / FE2/S2 (INORGANIC) CLUSTER


Mass: 175.820 Da / Num. of mol.: 4 / Formula: Fe2S2
#67: Chemical
ChemComp-SF4 / IRON/SULFUR CLUSTER


Mass: 351.640 Da / Num. of mol.: 6 / Formula: Fe4S4
#68: ChemicalChemComp-FMN / FLAVIN MONONUCLEOTIDE / RIBOFLAVIN MONOPHOSPHATE


Mass: 456.344 Da / Num. of mol.: 1 / Formula: C17H21N4O9P
#69: ChemicalChemComp-NDP / NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE


Mass: 745.421 Da / Num. of mol.: 1 / Formula: C21H30N7O17P3
#70: ChemicalChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 1 / Formula: Zn
#71: ChemicalChemComp-HEA / HEME-A


Mass: 852.837 Da / Num. of mol.: 2 / Formula: C49H56FeN4O6
#72: ChemicalChemComp-CU / COPPER (II) ION


Mass: 63.546 Da / Num. of mol.: 3 / Formula: Cu
#73: ChemicalChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 1 / Formula: Mg

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Details

Sequence detailsAuthor does not know the sequences of chains Ab, Ah, Ad, Ao, Ap, Av, Aq, As, Aw, Ar, At, Au

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Experimental details

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Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentReconstruction method: SINGLE PARTICLE

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Sample preparation

ComponentName: Respirasome / Details: Mammalian, respirasome / Type: COMPLEX
Specimen supportGrid material: COPPER / Grid mesh size: 400 / Grid type: Quantifoil R1.2/1.3
VitrificationCryogen name: NITROGEN

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Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyMicroscope model: FEI TITAN KRIOS
Electron gunElectron source: TUNGSTEN HAIRPIN / Accelerating voltage: 300 / Illumination mode: FLOOD BEAM
Electron lensMode: BRIGHT FIELD

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Processing

3D reconstructionResolution: 5.4 / Resolution method: FSC 0.143 CUT-OFF / Number of particles: 139996
Atomic model buildingRef protocol: RIGID BODY FIT / Ref space: REAL

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