Entry Database : EMDB / ID : EMD-41767 Downloads & linksTitle Structure of human Wnt3a bound to WLS and CALR Map data Details SampleComplex : Wnt3a-WLS-CALR ComplexProtein or peptide : Protein Wnt-3aProtein or peptide : Protein wntless homologProtein or peptide : CalreticulinLigand : PALMITOLEIC ACIDLigand : (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate Details Keywords SIGNALING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
Wnt signaling pathway involved in forebrain neuroblast division / positive regulation of dermatome development / axis elongation involved in somitogenesis / calcium ion transmembrane transport via low voltage-gated calcium channel / : / positive regulation of collateral sprouting in absence of injury / positive regulation of mesodermal cell fate specification / paraxial mesodermal cell fate commitment / cell proliferation in midbrain / spinal cord association neuron differentiation ... Wnt signaling pathway involved in forebrain neuroblast division / positive regulation of dermatome development / axis elongation involved in somitogenesis / calcium ion transmembrane transport via low voltage-gated calcium channel / : / positive regulation of collateral sprouting in absence of injury / positive regulation of mesodermal cell fate specification / paraxial mesodermal cell fate commitment / cell proliferation in midbrain / spinal cord association neuron differentiation / Formation of the posterior neural plate / Wnt protein secretion / Calnexin/calreticulin cycle / COP9 signalosome assembly / positive regulation of cell-cell adhesion mediated by cadherin / cytolytic granule / Wnt-Frizzled-LRP5/6 complex / positive regulation of Wnt protein secretion / Negative regulation of TCF-dependent signaling by WNT ligand antagonists / positive regulation of dendritic cell chemotaxis / synaptic vesicle recycling / Signaling by RNF43 mutants / WNT ligand biogenesis and trafficking / positive regulation of cardiac muscle cell differentiation / cortical granule / Assembly of Viral Components at the Budding Site / negative regulation of trophoblast cell migration / ATF6 (ATF6-alpha) activates chaperone genes / cell proliferation in forebrain / negative regulation of retinoic acid receptor signaling pathway / cellular response to electrical stimulus / endoplasmic reticulum quality control compartment / complement component C1q complex binding / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of meiotic nuclear division / secondary palate development / Specification of the neural plate border / negative regulation of axon extension involved in axon guidance / sequestering of calcium ion / cementum mineralization / response to glycoside / somatic stem cell division / non-canonical Wnt signaling pathway / co-receptor binding / sarcoplasmic reticulum lumen / cardiac muscle cell fate commitment / presynapse assembly / protein folding in endoplasmic reticulum / hindbrain development / positive regulation of skeletal muscle tissue development / nuclear export signal receptor activity / dorsal/ventral neural tube patterning / hormone binding / negative regulation of dopaminergic neuron differentiation / negative regulation of intracellular steroid hormone receptor signaling pathway / midbrain dopaminergic neuron differentiation / Wnt-protein binding / regulation of postsynapse to nucleus signaling pathway / molecular sequestering activity / cardiac muscle cell differentiation / exocrine pancreas development / post-anal tail morphogenesis / mammary gland development / positive regulation of neural precursor cell proliferation / frizzled binding / positive regulation of hepatocyte proliferation / Class B/2 (Secretin family receptors) / myoblast differentiation / Disassembly of the destruction complex and recruitment of AXIN to the membrane / anterior/posterior axis specification / protein maturation by protein folding / Scavenging by Class F Receptors / Scavenging by Class A Receptors / cortical actin cytoskeleton organization / nuclear androgen receptor binding / midbrain development / inner ear morphogenesis / regulation of synapse organization / cellular response to lithium ion / response to testosterone / negative regulation of fat cell differentiation / fat cell differentiation / B cell proliferation / heart looping / Formation of paraxial mesoderm / skeletal muscle cell differentiation / positive regulation of receptor internalization / hemopoiesis / protein localization to nucleus / regulation of presynapse assembly / mesoderm formation / negative regulation of neuron differentiation / positive regulation of Wnt signaling pathway / smooth endoplasmic reticulum / cell fate commitment / canonical Wnt signaling pathway / endomembrane system / positive regulation of cell cycle / regulation of microtubule cytoskeleton organization / ERAD pathway Similarity search - Function Wnt-3 protein / Protein wntless / : / Wntless-like, transmembrane domain / Wnt protein, conserved site / Wnt-1 family signature. / Wnt / Wnt, C-terminal domain / wnt family / found in Wnt-1 ... Wnt-3 protein / Protein wntless / : / Wntless-like, transmembrane domain / Wnt protein, conserved site / Wnt-1 family signature. / Wnt / Wnt, C-terminal domain / wnt family / found in Wnt-1 / Calreticulin / Calreticulin family repeated motif signature. / Calreticulin/calnexin / Calreticulin/calnexin, P domain superfamily / Calreticulin/calnexin, conserved site / Calreticulin family / Calreticulin family signature 1. / Calreticulin family signature 2. / Endoplasmic reticulum targeting sequence. / Concanavalin A-like lectin/glucanase domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 3.5 Å Details AuthorsQi X / Hu Q / Li X Funding support United States, 3 items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM135343 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) HL160487 United States Welch Foundation I-1957 United States
CitationJournal : To Be Published Title : Structure of human Wnt3a bound to WLS and CALRAuthors : Qi X / Hu Q / Li X History Deposition Aug 27, 2023 - Header (metadata) release Oct 18, 2023 - Map release Oct 18, 2023 - Update Oct 18, 2023 - Current status Oct 18, 2023 Processing site : RCSB / Status : Released
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