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- SASDEV9: Cytohesin-2; ARF nucleotide-binding site opener, ARNO truncation ... -

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Basic information

Entry
Database: SASBDB / ID: SASDEV9
SampleCytohesin-2; ARF nucleotide-binding site opener, ARNO truncation mutant
  • Cytohesin-2; ARNO truncation mutant (protein), ARNO-CC, Homo sapiens
Function / homology
Function and homology information


Intra-Golgi traffic / inositol 1,4,5 trisphosphate binding / regulation of ARF protein signal transduction / bicellular tight junction / guanyl-nucleotide exchange factor activity / adherens junction / endocytosis / actin cytoskeleton organization / growth cone / Golgi membrane ...Intra-Golgi traffic / inositol 1,4,5 trisphosphate binding / regulation of ARF protein signal transduction / bicellular tight junction / guanyl-nucleotide exchange factor activity / adherens junction / endocytosis / actin cytoskeleton organization / growth cone / Golgi membrane / lipid binding / membrane / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Sec7 domain / Sec7, C-terminal domain superfamily / Sec7 domain superfamily / Sec7 domain / SEC7 domain profile. / Sec7 domain / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
Contact author
  • Wenhua Zhang (CNRS UMR8113, ENS Paris-Saclay, Cachan, France)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #2191
Type: dummy / Radius of dummy atoms: 2.50 A / Symmetry: P1 / Chi-square value: 1.722 / P-value: 0.006663
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Cytohesin-2; ARF nucleotide-binding site opener, ARNO truncation mutant
Specimen concentration: 8 mg/ml
BufferName: 300 mM NaCl, 2 mM 2-mercaptoethanol and 30 mM Tris-HCl
pH: 7.5
Entity #1220Name: ARNO-CC / Type: protein / Description: Cytohesin-2; ARNO truncation mutant / Formula weight: 39.861 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q99418
Sequence: TLQRNRKMAM GRKKFNMDPK KGIQFLVENE LLQNTPEEIA RFLYKGEGLN KTAIGDYLGE REELNLAVLH AFVDLHEFTD LNLVQALRQF LWSFRLPGEA QKIDRMMEAF AQRYCLCNPG VFQSTDTCYV LSFAVIMLNT SLHNPNVRDK PGLERFVAMN RGINEGGDLP ...Sequence:
TLQRNRKMAM GRKKFNMDPK KGIQFLVENE LLQNTPEEIA RFLYKGEGLN KTAIGDYLGE REELNLAVLH AFVDLHEFTD LNLVQALRQF LWSFRLPGEA QKIDRMMEAF AQRYCLCNPG VFQSTDTCYV LSFAVIMLNT SLHNPNVRDK PGLERFVAMN RGINEGGDLP EELLRNLYDS IRNEPFKIPE DDGNDLTHTF FNPDREGWLL KLGGGRVKTW KRRWFILTDN CLYYFEYTTD KEPRGIIPLE NLSIREVDDP RKPNCFELYI PNNKGQLIKA CKTEADGRVV EGNHMVYRIS APTQEEKDEW IKSIQAAVSV DPFYEMLAAR KKRISVKKKQ EQP

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Experimental information

BeamInstrument name: SOLEIL SWING / City: Saint-Aubin / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.1033 Å / Dist. spec. to detc.: 1.8 mm
DetectorName: AVIEX PCCD170170 / Type: CCD
Scan
Title: Cytohesin-2; ARF nucleotide-binding site opener, ARNO truncation mutant
Measurement date: Nov 25, 2015 / Storage temperature: 15 °C / Cell temperature: 15 °C / Exposure time: 1.5 sec. / Number of frames: 1 / Unit: 1/A /
MinMax
Q0.0062 0.6125
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 452 /
MinMax
Q0.00845299 0.262423
P(R) point1 452
R0 98.89
Result
Type of curve: single_conc /
ExperimentalPorod
MW41.5 kDa39 kDa
Volume-63 nm3

P(R)GuinierGuinier error
Forward scattering, I00.03045 0.03041 1.0E-5
Radius of gyration, Rg2.77 nm2.745 nm0.02

MinMax
D-9.89
Guinier point5 69

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