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Open data
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Basic information
Entry | Database: SASBDB / ID: SASDB32 |
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![]() | Human Filamin A Ig-like domains 16-17 truncation (1782-1956)
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Function / homology | ![]() regulation of membrane repolarization during atrial cardiac muscle cell action potential / regulation of membrane repolarization during cardiac muscle cell action potential / establishment of Sertoli cell barrier / Myb complex / glycoprotein Ib-IX-V complex / adenylate cyclase-inhibiting dopamine receptor signaling pathway / formation of radial glial scaffolds / positive regulation of integrin-mediated signaling pathway / actin crosslink formation / tubulin deacetylation ...regulation of membrane repolarization during atrial cardiac muscle cell action potential / regulation of membrane repolarization during cardiac muscle cell action potential / establishment of Sertoli cell barrier / Myb complex / glycoprotein Ib-IX-V complex / adenylate cyclase-inhibiting dopamine receptor signaling pathway / formation of radial glial scaffolds / positive regulation of integrin-mediated signaling pathway / actin crosslink formation / tubulin deacetylation / blood coagulation, intrinsic pathway / protein localization to bicellular tight junction / OAS antiviral response / positive regulation of actin filament bundle assembly / positive regulation of neuron migration / Cell-extracellular matrix interactions / Fc-gamma receptor I complex binding / positive regulation of potassium ion transmembrane transport / apical dendrite / positive regulation of neural precursor cell proliferation / positive regulation of platelet activation / protein localization to cell surface / wound healing, spreading of cells / podosome / negative regulation of transcription by RNA polymerase I / megakaryocyte development / GP1b-IX-V activation signalling / receptor clustering / cortical cytoskeleton / SMAD binding / RHO GTPases activate PAKs / semaphorin-plexin signaling pathway / cilium assembly / mitotic spindle assembly / potassium channel regulator activity / release of sequestered calcium ion into cytosol / positive regulation of substrate adhesion-dependent cell spreading / negative regulation of DNA-binding transcription factor activity / protein sequestering activity / regulation of cell migration / dendritic shaft / protein localization to plasma membrane / actin filament / mRNA transcription by RNA polymerase II / establishment of protein localization / G protein-coupled receptor binding / negative regulation of protein catabolic process / cerebral cortex development / small GTPase binding / positive regulation of protein import into nucleus / platelet aggregation / kinase binding / Z disc / actin filament binding / Platelet degranulation / cell-cell junction / actin cytoskeleton / actin cytoskeleton organization / GTPase binding / growth cone / DNA-binding transcription factor binding / perikaryon / transmembrane transporter binding / positive regulation of canonical NF-kappaB signal transduction / postsynapse / protein stabilization / cadherin binding / focal adhesion / negative regulation of apoptotic process / nucleolus / perinuclear region of cytoplasm / glutamatergic synapse / protein homodimerization activity / RNA binding / extracellular exosome / extracellular region / nucleus / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function |
Biological species | ![]() |
![]() | ![]() Title: Skeletal Dysplasia Mutations Effect on Human Filamins’ Structure and Mechanosensing Authors: Seppälä J / Bernardi R / Haataja T / Hellman M / Pentikäinen O / Schulten K / Permi P / Ylänne J |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Related structure data | C: citing same article ( |
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Similar structure data |
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External links
Related items in Molecule of the Month |
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-Models
Model #382 | ![]() Type: dummy / Radius of dummy atoms: 1.75 A / Chi-square value: 1.096 ![]() |
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Sample
![]() | Name: Human Filamin A Ig-like domains 16-17 truncation (1782-1956) Specimen concentration: 1.00-5.00 |
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Buffer | Name: 20 mM Tris 50 mM NaCl 10 mM DTT / Concentration: 20.00 mM / Composition: 50mM NaCl, 10mM DTT |
Entity #246 | Name: FilaminA / Type: protein / Description: Human Filamin A Ig-like domains 16-17 / Formula weight: 18.7 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P21333 Sequence: GLDVTSLRPF DLVIPFTIKK GEITGEVRMP SGKVAQPTIT DNKDGTVTVR YAPSEAGLHE MDIRYDNMHI PGSPLQFYVD YVNCGHVTAY GPGLTHGVVN KPATFTVNTK DAGEGGLSLA IEGPSKAEIS CTDNQDGTCS VSYLPVLPGD YSILVKYNEQ HVPGSPFTAR VTGDD |
-Experimental information
Beam | Instrument name: ESRF BM29 / City: Grenoble / 国: France ![]() | ||||||||||||||||||||||||||||||||||||
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Detector | Name: Pilatus 1M | ||||||||||||||||||||||||||||||||||||
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