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- PDB-9f1d: Mammalian quaternary complex of a translating 80S ribosome, NAC, ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 9f1d | ||||||||||||||||||
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Title | Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK | ||||||||||||||||||
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![]() | TRANSLATION / ribosome / NAC / N-terminal acetyltransferase / NatA / NatE / MetAP1 / HYPK | ||||||||||||||||||
Function / homology | ![]() negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / negative regulation of protein localization to endoplasmic reticulum / nascent polypeptide-associated complex / regulation of skeletal muscle fiber development / : / negative regulation of striated muscle cell apoptotic process / mitotic sister chromatid cohesion, centromeric / peptide-glutamate-alpha-N-acetyltransferase activity / N-terminal methionine Nalpha-acetyltransferase NatE / N-terminal amino-acid Nalpha-acetyltransferase NatA ...negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric / negative regulation of protein localization to endoplasmic reticulum / nascent polypeptide-associated complex / regulation of skeletal muscle fiber development / : / negative regulation of striated muscle cell apoptotic process / mitotic sister chromatid cohesion, centromeric / peptide-glutamate-alpha-N-acetyltransferase activity / N-terminal methionine Nalpha-acetyltransferase NatE / N-terminal amino-acid Nalpha-acetyltransferase NatA / positive regulation of cell proliferation involved in heart morphogenesis / peptide-serine-alpha-N-acetyltransferase activity / NatA complex / N-terminal protein amino acid acetylation / positive regulation of skeletal muscle tissue growth / cardiac ventricle development / peptide alpha-N-acetyltransferase activity / N-terminal protein amino acid modification / peptidyl-methionine modification / skeletal muscle tissue regeneration / initiator methionyl aminopeptidase activity / histone H4 acetyltransferase activity / heart trabecula morphogenesis / establishment of mitotic sister chromatid cohesion / methionyl aminopeptidase / negative regulation of formation of translation preinitiation complex / metalloexopeptidase activity / N-acetyltransferase activity / GAIT complex / regulation of G1 to G0 transition / laminin receptor activity / exit from mitosis / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of translation involved in cellular response to UV / protein-DNA complex disassembly / positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / mitotic sister chromatid cohesion / optic nerve development / retinal ganglion cell axon guidance / mammalian oogenesis stage / G1 to G0 transition / homeostatic process / internal protein amino acid acetylation / protein acetylation / activation-induced cell death of T cells / macrophage chemotaxis / lung morphogenesis / metalloaminopeptidase activity / positive regulation of signal transduction by p53 class mediator / glutathione transferase / phagocytic cup / ubiquitin ligase inhibitor activity / protein maturation / glutathione transferase activity / TOR signaling / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / chromosome organization / 90S preribosome / T cell proliferation involved in immune response / protein-RNA complex assembly / erythrocyte development / negative regulation of ubiquitin-dependent protein catabolic process / translation regulator activity / cellular response to actinomycin D / ribosomal small subunit export from nucleus / aminopeptidase activity / cytosolic ribosome / laminin binding / endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rough endoplasmic reticulum / gastrulation / MDM2/MDM4 family protein binding / protein folding chaperone / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / glutathione metabolic process / class I DNA-(apurinic or apyrimidinic site) endonuclease activity / DNA-(apurinic or apyrimidinic site) lyase / rescue of stalled ribosome / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / positive regulation of apoptotic signaling pathway / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / ribosomal large subunit biogenesis / cellular response to leukemia inhibitory factor / maturation of SSU-rRNA / placenta development / small-subunit processome / positive regulation of translation / protein kinase C binding / wound healing / positive regulation of protein-containing complex assembly / G1/S transition of mitotic cell cycle / cellular response to gamma radiation / cellular response to type II interferon / platelet aggregation / transcription coactivator binding / mRNA 5'-UTR binding / modification-dependent protein catabolic process / spindle / cytoplasmic ribonucleoprotein granule Similarity search - Function | ||||||||||||||||||
Biological species | ![]() ![]() ![]() ![]() ![]() | ||||||||||||||||||
Method | ELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 3.26 Å | ||||||||||||||||||
![]() | Yudin, D. / Scaiola, A. / Ban, N. | ||||||||||||||||||
Funding support | ![]() ![]() ![]()
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![]() | ![]() Title: NAC guides a ribosomal multienzyme complex for nascent protein processing Authors: Lentzsch, A.M. / Yudin, D. / Gamerdinger, M. / Chandrasekar, S. / Rabl, L. / Scaiola, A. / Deuerling, E. / Ban, N. / Shan, S. | ||||||||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 5.4 MB | Display | ![]() |
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PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 50126MC ![]() 9f1bC ![]() 9f1cC M: map data used to model this data C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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Components
+RNA chain , 6 types, 6 molecules B5AHB7ATB8A2
+60S ribosomal protein ... , 23 types, 23 molecules BTBbBtBUBZBEBaBCAzBHBcBIBdBJBfBgBMBhBiBkBlBpBr
+40S ribosomal protein ... , 23 types, 23 molecules AqArAsAtAwAxAZAyAaAcAdAfAgAhAiAAABAkAlADAmAoAG
+Large ribosomal subunit protein ... , 11 types, 11 molecules BABPBBXBQBGBSBLBOBoBs
+Ribosomal protein ... , 12 types, 12 molecules BVBBBYAvBWBFBRBeAeBNBjAC
+Small ribosomal subunit protein ... , 6 types, 6 molecules AuAbAEAnAFAp
+Protein , 7 types, 7 molecules EACtCuDADDAjBm
+Protein/peptide , 1 types, 1 molecules BK
+N-alpha-acetyltransferase ... , 2 types, 2 molecules DBDC
+Non-polymers , 8 types, 2875 molecules ![](data/chem/img/UNX.gif)
![](data/chem/img/SPD.gif)
![](data/chem/img/MG.gif)
![](data/chem/img/SPM.gif)
![](data/chem/img/GTP.gif)
![](data/chem/img/IHP.gif)
![](data/chem/img/ZN.gif)
![](data/chem/img/HOH.gif)
![](data/chem/img/SPD.gif)
![](data/chem/img/MG.gif)
![](data/chem/img/SPM.gif)
![](data/chem/img/GTP.gif)
![](data/chem/img/IHP.gif)
![](data/chem/img/ZN.gif)
![](data/chem/img/HOH.gif)
+Details
-Experimental details
-Experiment
Experiment | Method: ELECTRON MICROSCOPY |
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EM experiment | Aggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction |
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Sample preparation
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