- PDB-6om7: Human ribosome nascent chain complex (PCSK9-RNC) stalled by a dru... -
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Basic information
Entry
Database: PDB / ID: 6om7
Title
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
Components
(40S ribosomal protein ...) x 32
(60S ribosomal protein ...) x 42
18S ribosomal RNA
28S ribosomal RNA
5.8S ribosomal RNA
5S ribosomal RNA
A/A site tRNA
P/E site tRNA
Proprotein convertase subtilisin/kexin type 9PCSK9
Receptor of activated protein C kinase 1
mRNAMessenger RNA
Keywords
RIBOSOME / selective stalling / drug-like small molecule / human ribosome nascent chain complex
Function / homology
Function and homology information
negative regulation of low-density lipoprotein particle receptor binding / negative regulation of receptor-mediated endocytosis involved in cholesterol transport / low-density lipoprotein particle receptor catabolic process / extrinsic component of external side of plasma membrane / PCSK9-LDLR complex / very-low-density lipoprotein particle binding / negative regulation of receptor recycling / PCSK9-AnxA2 complex / negative regulation of sodium ion transmembrane transporter activity / apolipoprotein receptor binding ...negative regulation of low-density lipoprotein particle receptor binding / negative regulation of receptor-mediated endocytosis involved in cholesterol transport / low-density lipoprotein particle receptor catabolic process / extrinsic component of external side of plasma membrane / PCSK9-LDLR complex / very-low-density lipoprotein particle binding / negative regulation of receptor recycling / PCSK9-AnxA2 complex / negative regulation of sodium ion transmembrane transporter activity / apolipoprotein receptor binding / negative regulation of low-density lipoprotein particle clearance / low-density lipoprotein particle binding / signaling receptor inhibitor activity / LDL clearance / positive regulation of low-density lipoprotein particle receptor catabolic process / lipoprotein metabolic process / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / embryonic brain development / eukaryotic 80S initiation complex / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / negative regulation of protein neddylation / protein tyrosine kinase inhibitor activity / translation at presynapse / positive regulation of respiratory burst involved in inflammatory response / axial mesoderm development / very-low-density lipoprotein particle receptor binding / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of gastrulation / negative regulation of formation of translation preinitiation complex / nucleolus organization / ribosomal protein import into nucleus / IRE1-RACK1-PP2A complex / : / positive regulation of endodeoxyribonuclease activity / positive regulation of Golgi to plasma membrane protein transport / 90S preribosome assembly / negative regulation of low-density lipoprotein receptor activity / TNFR1-mediated ceramide production / negative regulation of RNA splicing / negative regulation of DNA repair / negative regulation of receptor internalization / endolysosome membrane / TORC2 complex binding / laminin receptor activity / regulation of signaling receptor activity / GAIT complex / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / sodium channel inhibitor activity / oxidized purine DNA binding / supercoiled DNA binding / neural crest cell differentiation / middle ear morphogenesis / NF-kappaB complex / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / negative regulation of phagocytosis / positive regulation of ubiquitin-protein transferase activity / Formation of the ternary complex, and subsequently, the 43S complex / rRNA modification in the nucleus and cytosol / cytoplasmic side of rough endoplasmic reticulum membrane / erythrocyte homeostasis / A band / regulation of G1 to G0 transition / alpha-beta T cell differentiation / exit from mitosis / lysosomal transport / pigmentation / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of translation involved in cellular response to UV / protein kinase A binding / protein-DNA complex disassembly / positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / Ribosomal scanning and start codon recognition / negative regulation of ubiquitin protein ligase activity / optic nerve development / ion channel inhibitor activity / Translation initiation complex formation / mammalian oogenesis stage / positive regulation of mitochondrial depolarization / response to aldosterone / low-density lipoprotein particle receptor binding / retinal ganglion cell axon guidance / G1 to G0 transition / triglyceride metabolic process / homeostatic process / activation-induced cell death of T cells / lung morphogenesis / negative regulation of Wnt signaling pathway / fibroblast growth factor binding / positive regulation of T cell receptor signaling pathway / positive regulation of activated T cell proliferation / regulation of cell division / Protein hydroxylation / COPII-coated ER to Golgi transport vesicle / iron-sulfur cluster binding / BH3 domain binding Similarity search - Function
Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3 / Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2 / Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1 / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Proteinase K-like catalytic domain ...Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3 / Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2 / Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1 / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Proteinase K-like catalytic domain / Ubiquitin-like protein FUBI / Ribosomal protein L6, N-terminal / Ribosomal protein L6, N-terminal domain / Ribosomal protein L30e / Ribosomal protein L2, archaeal-type / Ribosomal protein L28e / Ribosomal protein L41 / Ribosomal L15/L27a, N-terminal / Ribosomal protein L41 / Peptidase S8 propeptide/proteinase inhibitor I9 / Peptidase inhibitor I9 / : / Ribosomal protein L23 / Peptidase S8 propeptide/proteinase inhibitor I9 superfamily / Ribosomal L28e/Mak16 / Ribosomal L28e protein family / Ribosomal protein S21e, conserved site / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S26e signature. / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein S2, eukaryotic / : / Ribosomal protein S21e signature. / Ribosomal protein S12e signature. / Serine proteases, subtilase domain profile. / metallochaperone-like domain / Ribosomal protein S12e / Ribosomal protein S5, eukaryotic/archaeal / TRASH domain / Peptidase S8, subtilisin-related / Ribosomal protein L29e / Ribosomal protein S2, eukaryotic/archaeal / Ribosomal L29e protein family / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Small (40S) ribosomal subunit Asc1/RACK1 / Peptidase S8/S53 domain superfamily / Subtilase family / Peptidase S8/S53 domain / 40S Ribosomal protein S10 / S27a-like superfamily / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein L22e / Plectin/S10, N-terminal / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Plectin/S10 domain / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / Ribosomal protein S25 / S25 ribosomal protein / : / Ribosomal protein L13e / Ribosomal protein L13e / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein L14e domain / Ribosomal protein S30 / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein L44e signature. / Ribosomal protein S7e signature. / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / Ribosomal protein L32e, conserved site / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein L10e / Ribosomal protein L19, eukaryotic / Ribosomal protein L14 / Ribosomal protein S19e / Ribosomal protein S3Ae, conserved site / Ribosomal protein S19e / Ribosomal protein S3Ae signature. / Ribosomal_S19e / Ribosomal protein L14, KOW motif / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein S27e signature. Similarity search - Domain/homology
Chem-MVM / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / FAU ubiquitin like and ribosomal protein S30 fusion / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein eL33 ...Chem-MVM / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / FAU ubiquitin like and ribosomal protein S30 fusion / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL16 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Small ribosomal subunit protein eS19 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 / Small ribosomal subunit protein eS27 / Large ribosomal subunit protein uL29 / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein uL18 / Large ribosomal subunit protein eL21 / Large ribosomal subunit protein eL28 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL34 / Large ribosomal subunit protein eL14 / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein eS1 / Large ribosomal subunit protein uL24 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein eL27 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL37 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Large ribosomal subunit protein eL8 / Small ribosomal subunit protein eS4, X isoform / Large ribosomal subunit protein uL23 / Small ribosomal subunit protein eS6 / Large ribosomal subunit protein uL14 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL32 / Large ribosomal subunit protein uL5 / Large ribosomal subunit protein uL2 / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eS31 fusion protein / Ubiquitin-ribosomal protein eL40 fusion protein / Large ribosomal subunit protein eL38 / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Large ribosomal subunit protein eL24 / Large ribosomal subunit protein eL42 / Large ribosomal subunit protein eL19 / Large ribosomal subunit protein eL20 / Large ribosomal subunit protein eL6 / Large ribosomal subunit protein eL18 / Proprotein convertase subtilisin/kexin type 9 / Large ribosomal subunit protein uL14 / Large ribosomal subunit protein eL36 Similarity search - Component
Biological species
Homo sapiens (human)
Method
ELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 3.7 Å
National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)
R01-GM065050
United States
Citation
Journal: Nat Struct Mol Biol / Year: 2019 Title: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Authors: Wenfei Li / Fred R Ward / Kim F McClure / Stacey Tsai-Lan Chang / Elizabeth Montabana / Spiros Liras / Robert G Dullea / Jamie H D Cate / Abstract: The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown mechanism. In structures of PF846-stalled human ...The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown mechanism. In structures of PF846-stalled human ribosome nascent chain complexes, PF846 binds in the ribosome exit tunnel in a eukaryotic-specific pocket formed by 28S ribosomal RNA, and alters the path of the nascent polypeptide chain. PF846 arrests the translating ribosome in the rotated state of translocation, in which the peptidyl-transfer RNA 3'-CCA end is improperly docked in the peptidyl transferase center. Selections of messenger RNAs from mRNA libraries using translation extracts reveal that PF846 can stall translation elongation, arrest termination or even enhance translation, depending on nascent chain sequence context. These results illuminate how a small molecule selectively targets translation by the human ribosome, and provides a foundation for developing small molecules that modulate the production of proteins of therapeutic interest.
S2: 18S ribosomal RNA SA: 40S ribosomal protein SA SB: 40S ribosomal protein S3a SD: 40S ribosomal protein S3 SE: 40S ribosomal protein S4, X isoform SF: 40S ribosomal protein S5 SH: 40S ribosomal protein S7 SI: 40S ribosomal protein S8 SK: 40S ribosomal protein S10 SL: 40S ribosomal protein S11 SP: 40S ribosomal protein S15 SQ: 40S ribosomal protein S16 SR: 40S ribosomal protein S17 SS: 40S ribosomal protein S18 ST: 40S ribosomal protein S19 SU: 40S ribosomal protein S20 SV: 40S ribosomal protein S21 SX: 40S ribosomal protein S23 Sa: 40S ribosomal protein S26 Sc: 40S ribosomal protein S28 Sd: 40S ribosomal protein S29 Sg: Receptor of activated protein C kinase 1 SC: 40S ribosomal protein S2 SG: 40S ribosomal protein S6 SJ: 40S ribosomal protein S9 SM: 40S ribosomal protein S12 SN: 40S ribosomal protein S13 SO: 40S ribosomal protein S14 SW: 40S ribosomal protein S15a SY: 40S ribosomal protein S24 SZ: 40S ribosomal protein S25 Sb: 40S ribosomal protein S27 Se: 40S ribosomal protein S30 Sf: 40S ribosomal protein S27a A: 60S ribosomal protein L8 B: 60S ribosomal protein L3 C: 60S ribosomal protein L4 D: 5.8S ribosomal RNA E: 5S ribosomal RNA F: 60S ribosomal protein L5 G: 60S ribosomal protein L6 H: 60S ribosomal protein L7 I: 60S ribosomal protein L7a J: 60S ribosomal protein L9 K: 60S ribosomal protein L10 L: 60S ribosomal protein L11 M: 60S ribosomal protein L13 N: 60S ribosomal protein L14 O: 60S ribosomal protein L15 P: 60S ribosomal protein L13a Q: 60S ribosomal protein L17 R: 60S ribosomal protein L18 S: 60S ribosomal protein L19 T: 60S ribosomal protein L18a U: 60S ribosomal protein L21 V: 60S ribosomal protein L22 W: 60S ribosomal protein L23 X: 60S ribosomal protein L24 Y: 60S ribosomal protein L23a Z: 60S ribosomal protein L26 a: 60S ribosomal protein L27 b: 60S ribosomal protein L27a c: 60S ribosomal protein L29 d: 60S ribosomal protein L30 e: 60S ribosomal protein L31 f: 60S ribosomal protein L32 g: 60S ribosomal protein L35a h: 60S ribosomal protein L34 i: 60S ribosomal protein L35 j: 60S ribosomal protein L36 k: 60S ribosomal protein L37 l: 60S ribosomal protein L38 m: 60S ribosomal protein L39 n: 60S ribosomal protein L40 o: 60S ribosomal protein L41 p: 60S ribosomal protein L36a q: 60S ribosomal protein L37a r: 60S ribosomal protein L28 t: 28S ribosomal RNA v: A/A site tRNA w: mRNA u: P/E site tRNA y: Proprotein convertase subtilisin/kexin type 9 hetero molecules
Mass: 24774.365 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P08865
#3: Protein
40SribosomalproteinS3a / / Small ribosomal subunit protein eS1 / v-fos transformation effector protein / Fte-1
Mass: 24888.258 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61247
#4: Protein
40SribosomalproteinS3 / / Small ribosomal subunit protein uS3
Mass: 25041.365 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P23396
#5: Protein
40SribosomalproteinS4, Xisoform / Ribosome / SCR10 / Single copy abundant mRNA protein / Small ribosomal subunit protein eS4
Mass: 29292.465 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62701
#6: Protein
40SribosomalproteinS5 / / Small ribosomal subunit protein uS7
Mass: 21327.723 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46782
#7: Protein
40SribosomalproteinS7 / / Small ribosomal subunit protein eS7
Mass: 21603.229 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62081
#8: Protein
40SribosomalproteinS8 / / Small ribosomal subunit protein eS8
Mass: 23816.779 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62241
#9: Protein
40SribosomalproteinS10 / / Small ribosomal subunit protein eS10
Mass: 11773.953 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46783
#10: Protein
40SribosomalproteinS11 / / Small ribosomal subunit protein uS17
Mass: 17785.971 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62280
#11: Protein
40SribosomalproteinS15 / / RIG protein / Small ribosomal subunit protein uS19
Mass: 14931.620 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62841
#12: Protein
40SribosomalproteinS16 / / Small ribosomal subunit protein uS9
Mass: 16477.377 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62249
#13: Protein
40SribosomalproteinS17 / / Small ribosomal subunit protein eS17
Mass: 15446.961 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P08708
#14: Protein
40SribosomalproteinS18 / / Ke-3 / Ke3 / Small ribosomal subunit protein uS13
Mass: 17029.844 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62269
#15: Protein
40SribosomalproteinS19 / / Small ribosomal subunit protein eS19
Mass: 15822.219 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P39019
#16: Protein
40SribosomalproteinS20 / / Small ribosomal subunit protein uS10
Mass: 11765.890 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P60866
#17: Protein
40SribosomalproteinS21 / / Small ribosomal subunit protein eS21
Mass: 8977.214 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63220
#18: Protein
40SribosomalproteinS23 / / Small ribosomal subunit protein uS12
Mass: 15626.392 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62266
#19: Protein
40SribosomalproteinS26 / / Small ribosomal subunit protein eS26
Mass: 11742.908 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62854
#20: Protein
40SribosomalproteinS28 / / Small ribosomal subunit protein eS28
Mass: 7263.394 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62857
#21: Protein
40SribosomalproteinS29 / / Small ribosomal subunit protein uS14
Mass: 6559.625 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62273
#23: Protein
40SribosomalproteinS2 / / 40S ribosomal protein S4 / Protein LLRep3 / Small ribosomal subunit protein uS5
Mass: 24330.705 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P15880
#24: Protein
40SribosomalproteinS6 / / Phosphoprotein NP33 / Small ribosomal subunit protein eS6
Mass: 27471.535 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62753
#25: Protein
40SribosomalproteinS9 / / Small ribosomal subunit protein uS4
Mass: 21649.633 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46781
#26: Protein
40SribosomalproteinS12 / / Small ribosomal subunit protein eS12
Mass: 13217.382 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P25398
#27: Protein
40SribosomalproteinS13 / / Small ribosomal subunit protein uS15
Mass: 17128.191 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62277
#28: Protein
40SribosomalproteinS14 / / Small ribosomal subunit protein uS11
Mass: 14657.815 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62263
#29: Protein
40SribosomalproteinS15a / / Small ribosomal subunit protein uS8
Mass: 14734.357 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62244
#30: Protein
40SribosomalproteinS24 / / Small ribosomal subunit protein eS24
Mass: 15203.022 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62847
#31: Protein
40SribosomalproteinS25 / / Small ribosomal subunit protein eS25
Mass: 8253.838 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62851
#32: Protein
40SribosomalproteinS27 / / Metallopan-stimulin 1 / MPS-1 / Small ribosomal subunit protein eS27
Mass: 9210.843 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P42677
#33: Protein
40SribosomalproteinS30 /
Mass: 6452.681 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: E9PR30, UniProt: P62861*PLUS
#34: Protein
40SribosomalproteinS27a / / Ubiquitin carboxyl extension protein 80
Mass: 7884.286 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62979
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60S ribosomal protein ... , 42 types, 42 molecules ABCFGHIJKLMNOPQRSTUVWXYZabcdef...
#35: Protein
60SribosomalproteinL8 / / Large ribosomal subunit protein uL2
Mass: 27456.158 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62917
#36: Protein
60SribosomalproteinL3 / / HIV-1 TAR RNA-binding protein B / TARBP-B / Large ribosomal subunit protein uL3
Mass: 45564.379 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P39023
#37: Protein
60SribosomalproteinL4 / / 60S ribosomal protein L1 / Large ribosomal subunit protein uL4
Mass: 41171.547 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P36578
#40: Protein
60SribosomalproteinL5 / / Large ribosomal subunit protein uL18
Mass: 34091.371 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46777
#41: Protein
60SribosomalproteinL6 / / Large ribosomal subunit protein eL6 / Neoplasm-related protein C140 / Tax-responsive enhancer ...Large ribosomal subunit protein eL6 / Neoplasm-related protein C140 / Tax-responsive enhancer element-binding protein 107 / TaxREB107
Mass: 28378.824 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q02878
#42: Protein
60SribosomalproteinL7 / / Large ribosomal subunit protein uL30
Mass: 26590.725 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18124
#43: Protein
60SribosomalproteinL7a / / Large ribosomal subunit protein eL8 / PLA-X polypeptide / Surfeit locus protein 3
Mass: 26724.568 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62424
#44: Protein
60SribosomalproteinL9 / / Large ribosomal subunit protein uL6
Mass: 21770.355 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P32969
#45: Protein
60SribosomalproteinL10 / / Laminin receptor homolog / Large ribosomal subunit protein uL16 / Protein QM / Ribosomal protein ...Laminin receptor homolog / Large ribosomal subunit protein uL16 / Protein QM / Ribosomal protein L10 / Tumor suppressor QM
Mass: 24381.760 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P27635
#46: Protein
60SribosomalproteinL11 / / CLL-associated antigen KW-12 / Large ribosomal subunit protein uL5
Mass: 19270.318 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62913
#47: Protein
60SribosomalproteinL13 / / Breast basic conserved protein 1 / Large ribosomal subunit protein eL13
Mass: 23574.697 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P26373
#48: Protein
60SribosomalproteinL14 / / CAG-ISL 7 / Large ribosomal subunit protein eL14
Mass: 16220.309 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P50914
#49: Protein
60SribosomalproteinL15 / / Large ribosomal subunit protein eL15
Mass: 24076.088 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61313
#50: Protein
60SribosomalproteinL13a / / 23 kDa highly basic protein / Large ribosomal subunit protein uL13
Mass: 22820.395 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P40429
#51: Protein
60SribosomalproteinL17 / / 60S ribosomal protein L23 / Large ribosomal subunit protein uL22 / PD-1
Mass: 17757.627 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18621
#52: Protein
60SribosomalproteinL18 / / Large ribosomal subunit protein eL18
Mass: 21556.482 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q07020
#53: Protein
60SribosomalproteinL19 / / Large ribosomal subunit protein eL19
Mass: 21742.146 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P84098
#54: Protein
60SribosomalproteinL18a / / Large ribosomal subunit protein eL20
Mass: 20661.340 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q02543
#55: Protein
60SribosomalproteinL21 / / Large ribosomal subunit protein eL21
Mass: 18276.518 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46778
#56: Protein
60SribosomalproteinL22 / / EBER-associated protein / EAP / Epstein-Barr virus small RNA-associated protein / Heparin-binding ...EBER-associated protein / EAP / Epstein-Barr virus small RNA-associated protein / Heparin-binding protein HBp15 / Large ribosomal subunit protein eL22
Mass: 11481.248 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P35268
#57: Protein
60SribosomalproteinL23 /
Mass: 13828.295 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BTQ7, UniProt: P62829*PLUS
#58: Protein
60SribosomalproteinL24 / / 60S ribosomal protein L30 / Large ribosomal subunit protein eL24
Mass: 14087.417 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P83731
#59: Protein
60SribosomalproteinL23a / / Large ribosomal subunit protein uL23
Mass: 13614.023 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62750
#60: Protein
60SribosomalproteinL26 / / Large ribosomal subunit protein uL24
Mass: 15891.787 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61254
#61: Protein
60SribosomalproteinL27 / / Large ribosomal subunit protein eL27
Mass: 15647.584 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61353
#62: Protein
60SribosomalproteinL27a / / Large ribosomal subunit protein uL15
Mass: 16473.340 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46776
#63: Protein
60SribosomalproteinL29 / / Cell surface heparin-binding protein HIP / Large ribosomal subunit protein eL29
Mass: 13965.825 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P47914
#64: Protein
60SribosomalproteinL30 / / Large ribosomal subunit protein eL30
Mass: 11500.556 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62888
#65: Protein
60SribosomalproteinL31 / / Large ribosomal subunit protein eL31
Mass: 12506.581 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62899
#66: Protein
60SribosomalproteinL32 / / Large ribosomal subunit protein eL32
Mass: 15179.215 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62910
#67: Protein
60SribosomalproteinL35a / / Cell growth-inhibiting gene 33 protein / Large ribosomal subunit protein eL33
Mass: 12433.548 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18077
#68: Protein
60SribosomalproteinL34 / / Large ribosomal subunit protein eL34
Mass: 12994.621 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P49207
#69: Protein
60SribosomalproteinL35 / / Large ribosomal subunit protein uL29
Mass: 14462.429 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P42766
#70: Protein
60SribosomalproteinL36 / / Large ribosomal subunit protein eL36
Mass: 11373.708 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3U8
#71: Protein
60SribosomalproteinL37 / / G1.16 / Large ribosomal subunit protein eL37
Mass: 9864.596 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61927
#72: Protein
60SribosomalproteinL38 / / Large ribosomal subunit protein eL38
Mass: 8107.752 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63173
#73: Protein/peptide
60SribosomalproteinL39 / / Large ribosomal subunit protein eL39
Mass: 6295.562 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62891
Mass: 5957.237 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62987
#75: Protein/peptide
60SribosomalproteinL41 / / HG12 / Large ribosomal subunit protein eL41
Mass: 3473.451 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62945
#76: Protein
60SribosomalproteinL36a / / 60S ribosomal protein L44 / Cell growth-inhibiting gene 15 protein / Cell migration-inducing gene 6 ...60S ribosomal protein L44 / Cell growth-inhibiting gene 15 protein / Cell migration-inducing gene 6 protein / Large ribosomal subunit protein eL42
Mass: 12345.776 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P83881
#77: Protein
60SribosomalproteinL37a / / Large ribosomal subunit protein eL43
Mass: 10168.153 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61513
#78: Protein
60SribosomalproteinL28 / / Large ribosomal subunit protein eL28
Mass: 13991.366 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46779
-
Protein / Protein/peptide , 2 types, 2 molecules Sgy
#22: Protein
ReceptorofactivatedproteinCkinase1 / Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2- ...Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2-like 1 / Guanine nucleotide-binding protein subunit beta-like protein 12.3 / Human lung cancer oncogene 7 protein / HLC-7 / Receptor for activated C kinase / Small ribosomal subunit protein RACK1
Mass: 34568.012 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63244
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