登録情報 | データベース: EMDB / ID: EMD-44586 |
---|
タイトル | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry |
---|
マップデータ | B-factor sharpened map |
---|
試料 | - 複合体: Di-heterotetrameric GluN1-GluN2B NMDA receptors
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 1
- タンパク質・ペプチド: Glutamate receptor
- リガンド: GLYCINE
- リガンド: GLUTAMIC ACID
|
---|
キーワード | Ionotropic glutamate receptor / synaptic membrane protein / MEMBRANE PROTEIN |
---|
機能・相同性 | 機能・相同性情報
organelle / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration / EPHB-mediated forward signaling / Assembly and cell surface presentation of NMDA receptors / olfactory learning / conditioned taste aversion / dendritic branch / regulation of respiratory gaseous exchange ...organelle / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration / EPHB-mediated forward signaling / Assembly and cell surface presentation of NMDA receptors / olfactory learning / conditioned taste aversion / dendritic branch / regulation of respiratory gaseous exchange / protein localization to postsynaptic membrane / propylene metabolic process / response to glycine / voltage-gated monoatomic cation channel activity / regulation of monoatomic cation transmembrane transport / response to morphine / NMDA glutamate receptor activity / Synaptic adhesion-like molecules / NMDA selective glutamate receptor complex / RAF/MAP kinase cascade / parallel fiber to Purkinje cell synapse / calcium ion transmembrane import into cytosol / glutamate binding / neuromuscular process / positive regulation of reactive oxygen species biosynthetic process / protein heterotetramerization / regulation of synapse assembly / glycine binding / positive regulation of calcium ion transport into cytosol / regulation of dendrite morphogenesis / regulation of axonogenesis / male mating behavior / suckling behavior / startle response / response to amine / monoatomic cation transmembrane transport / regulation of neuronal synaptic plasticity / monoatomic cation transport / associative learning / positive regulation of excitatory postsynaptic potential / social behavior / ligand-gated monoatomic ion channel activity / excitatory synapse / cellular response to glycine / positive regulation of dendritic spine maintenance / Unblocking of NMDA receptors, glutamate binding and activation / phosphatase binding / cellular response to manganese ion / glutamate-gated calcium ion channel activity / calcium ion homeostasis / glutamate receptor binding / prepulse inhibition / monoatomic cation channel activity / long-term memory / regulation of neuron apoptotic process / synaptic cleft / glutamate-gated receptor activity / presynaptic active zone membrane / response to fungicide / sensory perception of pain / dendrite membrane / ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / response to amphetamine / excitatory postsynaptic potential / ionotropic glutamate receptor signaling pathway / hippocampal mossy fiber to CA3 synapse / positive regulation of synaptic transmission, glutamatergic / adult locomotory behavior / learning / synaptic membrane / synaptic transmission, glutamatergic / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / regulation of membrane potential / postsynaptic density membrane / regulation of long-term neuronal synaptic plasticity / calcium channel activity / visual learning / regulation of synaptic plasticity / response to organic cyclic compound / terminal bouton / memory / cerebral cortex development / synaptic vesicle membrane / intracellular calcium ion homeostasis / neuron cellular homeostasis / response to calcium ion / calcium ion transport / rhythmic process / synaptic vesicle / presynaptic membrane / signaling receptor activity / amyloid-beta binding / protein-containing complex assembly / chemical synaptic transmission / postsynaptic membrane / response to ethanol / negative regulation of neuron apoptotic process / transcription by RNA polymerase II / dendritic spine / postsynaptic density類似検索 - 分子機能 Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel ...Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Glutamate receptor / Glutamate receptor ionotropic, NMDA 1類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.81 Å |
---|
データ登録者 | Chou T-H / Furukawa H |
---|
資金援助 | 米国, 2件 Organization | Grant number | 国 |
---|
National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS111745 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | MH085926 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Molecular mechanism of ligand-gating in NMDA receptor channel 著者: Chou T-H / Furukawa H |
---|
履歴 | 登録 | 2024年4月23日 | - |
---|
ヘッダ(付随情報) 公開 | 2024年7月31日 | - |
---|
マップ公開 | 2024年7月31日 | - |
---|
更新 | 2024年7月31日 | - |
---|
現状 | 2024年7月31日 | 処理サイト: RCSB / 状態: 公開 |
---|
|
---|