+Open data
-Basic information
Entry | Database: PDB / ID: 7jxt | ||||||||||||
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Title | Ovine COX-1 in complex with the subtype-selective derivative 2a | ||||||||||||
Components | Prostaglandin G/H synthase 1 | ||||||||||||
Keywords | OXIDOREDUCTASE/INHIBITOR / Cyclooxygenase-1 / oxidoreductase inhibitor / OXIDOREDUCTASE / OXIDOREDUCTASE-INHIBITOR complex | ||||||||||||
Function / homology | Function and homology information prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle ...prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle / heme binding / endoplasmic reticulum membrane / protein homodimerization activity / metal ion binding / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Ovis aries (sheep) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.35 Å | ||||||||||||
Authors | Ko, Y. / Iaselli, M. / Miciaccia, M. / Friedrich, L. / Schneider, G. / Scilimati, A. / Cingolani, G. | ||||||||||||
Funding support | United States, 3items
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Citation | Journal: Adv Sci / Year: 2021 Title: Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. Authors: Friedrich, L. / Cingolani, G. / Ko, Y.H. / Iaselli, M. / Miciaccia, M. / Perrone, M.G. / Neukirch, K. / Bobinger, V. / Merk, D. / Hofstetter, R.K. / Werz, O. / Koeberle, A. / Scilimati, A. / Schneider, G. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7jxt.cif.gz | 658.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7jxt.ent.gz | 563.1 KB | Display | PDB format |
PDBx/mmJSON format | 7jxt.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7jxt_validation.pdf.gz | 3.1 MB | Display | wwPDB validaton report |
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Full document | 7jxt_full_validation.pdf.gz | 3.2 MB | Display | |
Data in XML | 7jxt_validation.xml.gz | 26.8 KB | Display | |
Data in CIF | 7jxt_validation.cif.gz | 38 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/jx/7jxt ftp://data.pdbj.org/pub/pdb/validation_reports/jx/7jxt | HTTPS FTP |
-Related structure data
Related structure data | 5wbeS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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