登録情報 | データベース: PDB / ID: 6xq8 |
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タイトル | Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 11 |
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要素 | Advanced glycosylation end product-specific receptor |
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キーワード | SIGNALING PROTEIN / RAGE / IG-like domain / receptor / Advanced Glycation End Products |
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機能・相同性 | 機能・相同性情報
regulation of CD4-positive, alpha-beta T cell activation / negative regulation of blood circulation / advanced glycation end-product receptor activity / positive regulation of endothelin production / regulation of T cell mediated cytotoxicity / glucose mediated signaling pathway / negative regulation of long-term synaptic depression / positive regulation of monocyte extravasation / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / positive regulation of dendritic cell differentiation ...regulation of CD4-positive, alpha-beta T cell activation / negative regulation of blood circulation / advanced glycation end-product receptor activity / positive regulation of endothelin production / regulation of T cell mediated cytotoxicity / glucose mediated signaling pathway / negative regulation of long-term synaptic depression / positive regulation of monocyte extravasation / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / positive regulation of dendritic cell differentiation / regulation of p38MAPK cascade / regulation of non-canonical NF-kappaB signal transduction / scavenger receptor activity / induction of positive chemotaxis / transcytosis / protein localization to membrane / positive regulation of monocyte chemotactic protein-1 production / positive regulation of heterotypic cell-cell adhesion / S100 protein binding / regulation of long-term synaptic potentiation / regulation of spontaneous synaptic transmission / laminin receptor activity / positive regulation of p38MAPK cascade / negative regulation of interleukin-10 production / positive regulation of activated T cell proliferation / response to amyloid-beta / TRAF6 mediated NF-kB activation / Advanced glycosylation endproduct receptor signaling / transport across blood-brain barrier / negative regulation of long-term synaptic potentiation / positive regulation of chemokine production / positive regulation of interleukin-12 production / astrocyte activation / positive regulation of interleukin-1 beta production / positive regulation of JNK cascade / microglial cell activation / TAK1-dependent IKK and NF-kappa-B activation / positive regulation of non-canonical NF-kappaB signal transduction / regulation of synaptic plasticity / transmembrane signaling receptor activity / fibrillar center / response to wounding / positive regulation of interleukin-6 production / cellular response to amyloid-beta / cell junction / positive regulation of tumor necrosis factor production / neuron projection development / regulation of inflammatory response / signaling receptor activity / positive regulation of NF-kappaB transcription factor activity / amyloid-beta binding / postsynapse / positive regulation of ERK1 and ERK2 cascade / learning or memory / cell surface receptor signaling pathway / molecular adaptor activity / response to hypoxia / positive regulation of protein phosphorylation / apical plasma membrane / inflammatory response / protein-containing complex binding / cell surface / extracellular region / identical protein binding / plasma membrane類似検索 - 分子機能 : / CD80-like, immunoglobulin C2-set / CD80-like C2-set immunoglobulin domain / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulin subtype ...: / CD80-like, immunoglobulin C2-set / CD80-like C2-set immunoglobulin domain / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulin subtype / Immunoglobulin / Immunoglobulins and major histocompatibility complex proteins signature. / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold類似検索 - ドメイン・相同性 ACETATE ION / 7-methyl-3-phenyl-1H-indole-2-carboxylic acid / 3-phenoxyphenol / Advanced glycosylation end product-specific receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.82 Å |
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データ登録者 | Salay, L.E. / Kozlyuk, N. / Gilston, B.A. / Gogliotti, R.D. / Christov, P.P. / Kim, K. / Ovee, M. / Waterson, A.G. / Chazin, W.J. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI101171 | 米国 |
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引用 | ジャーナル: Proteins / 年: 2021 タイトル: A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors. 著者: Kozlyuk, N. / Gilston, B.A. / Salay, L.E. / Gogliotti, R.D. / Christov, P.P. / Kim, K. / Ovee, M. / Waterson, A.G. / Chazin, W.J. |
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履歴 | 登録 | 2020年7月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年7月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年7月28日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID |
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改定 1.2 | 2021年8月4日 | Group: Database references / カテゴリ: citation_author / Item: _citation_author.identifier_ORCID |
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改定 1.3 | 2021年8月11日 | Group: Database references / カテゴリ: database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.4 | 2021年10月20日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.5 | 2021年12月15日 | Group: Database references / Structure summary / カテゴリ: audit_author / citation_author Item: _audit_author.identifier_ORCID / _citation_author.identifier_ORCID |
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改定 1.6 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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