登録情報 | データベース: PDB / ID: 6rz9 |
---|
タイトル | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372 |
---|
要素 | Cysteinyl leukotriene receptor 2,Soluble cytochrome b562,Cysteinyl leukotriene receptor 2 |
---|
キーワード | MEMBRANE PROTEIN / GPCR / LCP / cysteinyl leukotriene / cyslt2 / cysltr2 / cyslt2r / asthma / BRIL / Cysteinyl Leukotriene Receptor 2 |
---|
機能・相同性 | 機能・相同性情報
cysteinyl leukotriene receptor activity / leukotriene receptor activity / Leukotriene receptors / LTC4-CYSLTR mediated IL4 production / G protein-coupled peptide receptor activity / neuropeptide signaling pathway / electron transport chain / G alpha (s) signalling events / G alpha (q) signalling events / periplasmic space ...cysteinyl leukotriene receptor activity / leukotriene receptor activity / Leukotriene receptors / LTC4-CYSLTR mediated IL4 production / G protein-coupled peptide receptor activity / neuropeptide signaling pathway / electron transport chain / G alpha (s) signalling events / G alpha (q) signalling events / periplasmic space / electron transfer activity / iron ion binding / immune response / heme binding / plasma membrane類似検索 - 分子機能 Cysteinyl leukotriene receptor 2 / Cysteinyl leukotriene receptor / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 CHOLESTEROL / Chem-KO5 / OLEIC ACID / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Soluble cytochrome b562 / Cysteinyl leukotriene receptor 2類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト)
![](img/tx_bacteria.gif) Escherichia coli (大腸菌) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.73 Å |
---|
データ登録者 | Gusach, A. / Luginina, A. / Marin, E. / Brouillette, R.L. / Besserer-Offroy, E. / Longpre, J.M. / Ishchenko, A. / Popov, P. / Fujimoto, T. / Maruyama, T. ...Gusach, A. / Luginina, A. / Marin, E. / Brouillette, R.L. / Besserer-Offroy, E. / Longpre, J.M. / Ishchenko, A. / Popov, P. / Fujimoto, T. / Maruyama, T. / Stauch, B. / Ergasheva, M. / Romanovskaya, D. / Stepko, A. / Kovalev, K. / Shevtsov, M. / Gordeliy, V. / Han, G.W. / Sarret, P. / Katritch, V. / Borshchevskiy, V. / Mishin, A. / Cherezov, V. |
---|
資金援助 | ロシア, 米国, カナダ, 4件 組織 | 認可番号 | 国 |
---|
Russian Science Foundation | 16-14-10273 | ロシア | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35 GM127086 | 米国 | Canadian Institutes of Health Research | | カナダ | Fonds de Recherche du Quebec - Nature et Technologies | | カナダ |
|
---|
引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. 著者: Gusach, A. / Luginina, A. / Marin, E. / Brouillette, R.L. / Besserer-Offroy, E. / Longpre, J.M. / Ishchenko, A. / Popov, P. / Patel, N. / Fujimoto, T. / Maruyama, T. / Stauch, B. / Ergasheva, ...著者: Gusach, A. / Luginina, A. / Marin, E. / Brouillette, R.L. / Besserer-Offroy, E. / Longpre, J.M. / Ishchenko, A. / Popov, P. / Patel, N. / Fujimoto, T. / Maruyama, T. / Stauch, B. / Ergasheva, M. / Romanovskaia, D. / Stepko, A. / Kovalev, K. / Shevtsov, M. / Gordeliy, V. / Han, G.W. / Katritch, V. / Borshchevskiy, V. / Sarret, P. / Mishin, A. / Cherezov, V. |
---|
履歴 | 登録 | 2019年6月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2019年12月11日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2019年12月18日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
---|
改定 1.2 | 2022年3月30日 | Group: Author supporting evidence / Database references ...Author supporting evidence / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / database_2 ...chem_comp / database_2 / entity / pdbx_audit_support / pdbx_entity_nonpoly Item: _chem_comp.name / _database_2.pdbx_DOI ..._chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_audit_support.funding_organization / _pdbx_entity_nonpoly.name |
---|
改定 1.3 | 2024年1月24日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|