登録情報 | データベース: PDB / ID: 6q1n |
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タイトル | Glucocerebrosidase in complex with pharmacological chaperone IMX8 |
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要素 | Glucosylceramidase |
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キーワード | HYDROLASE/INHIBITOR / pharmacological chaperone / Gaucher disease / glycosidase / inhibitor / pKa / HYDROLASE / HYDROLASE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
positive regulation of protein lipidation / steryl-beta-glucosidase activity / beta-glucoside catabolic process / positive regulation of neuronal action potential / cerebellar Purkinje cell layer formation / positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization / galactosylceramidase / termination of signal transduction / galactosylceramidase activity / lymphocyte migration ...positive regulation of protein lipidation / steryl-beta-glucosidase activity / beta-glucoside catabolic process / positive regulation of neuronal action potential / cerebellar Purkinje cell layer formation / positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization / galactosylceramidase / termination of signal transduction / galactosylceramidase activity / lymphocyte migration / glucosylceramidase / scavenger receptor binding / glucosylceramide catabolic process / regulation of lysosomal protein catabolic process / autophagosome organization / glucosylceramidase activity / microglial cell proliferation / sphingosine biosynthetic process / glucosyltransferase activity / regulation of TOR signaling / ceramide biosynthetic process / lipid storage / microglia differentiation / response to thyroid hormone / Glycosphingolipid catabolism / pyramidal neuron differentiation / lipid glycosylation / brain morphogenesis / 加水分解酵素; 糖加水分解酵素; 配糖体結合加水分解酵素または糖加水分解酵素 / response to pH / positive regulation of protein-containing complex disassembly / motor behavior / neuromuscular process / 転移酵素; グリコシル基を移すもの; 六炭糖残基を移すもの / hematopoietic stem cell proliferation / lysosome organization / response to testosterone / glycosyltransferase activity / response to dexamethasone / Association of TriC/CCT with target proteins during biosynthesis / antigen processing and presentation / negative regulation of interleukin-6 production / homeostasis of number of cells / regulation of macroautophagy / establishment of skin barrier / negative regulation of protein-containing complex assembly / positive regulation of protein dephosphorylation / cell maturation / cellular response to starvation / respiratory electron transport chain / cholesterol metabolic process / lysosomal lumen / negative regulation of MAP kinase activity / determination of adult lifespan / trans-Golgi network / autophagy / negative regulation of inflammatory response / response to estrogen / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / cellular response to tumor necrosis factor / T cell differentiation in thymus / proteasome-mediated ubiquitin-dependent protein catabolic process / neuron apoptotic process / negative regulation of neuron apoptotic process / lysosome / lysosomal membrane / signaling receptor binding / Golgi apparatus / endoplasmic reticulum / extracellular exosome類似検索 - 分子機能 Glycosyl hydrolase family 30, TIM-barrel domain / Glycosyl hydrolase family 30 TIM-barrel domain / Glycosyl hydrolase family 30, beta sandwich domain / Glycosyl hydrolase family 30 beta sandwich domain / Glycoside hydrolase family 30 / Glycoside hydrolase superfamily類似検索 - ドメイン・相同性 Chem-P9V / Glucosylceramidase / Lysosomal acid glucosylceramidase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.526 Å |
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データ登録者 | Vickers, C. / Withers, S.G. / Boraston, A.B. |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Canadian Institutes of Health Research (CIHR) | | カナダ |
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引用 | ジャーナル: To Be Published タイトル: Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models. 著者: Santana, A.G. / Robinson, K. / Vickers, C. / Chen, H. / Zhou, S. / Boraston, A.B. / Clarke, L.A. / Withers, S.G. |
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履歴 | 登録 | 2019年8月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年8月19日 | Provider: repository / タイプ: Initial release |
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