Entry | Database: PDB / ID: 6mib |
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Title | Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex |
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Components | - Alpha-parvin
- Integrin-linked protein kinase
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Keywords | CELL ADHESION / Pseudokinase / Protein complex |
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Function / homology | Function and homology information
actin-mediated cell contraction / smooth muscle cell chemotaxis / Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system ...actin-mediated cell contraction / smooth muscle cell chemotaxis / Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system / outflow tract septum morphogenesis / cell projection organization / positive regulation of BMP signaling pathway / neural precursor cell proliferation / establishment or maintenance of epithelial cell apical/basal polarity / heterotypic cell-cell adhesion / sprouting angiogenesis / establishment or maintenance of cell polarity / branching involved in ureteric bud morphogenesis / protein kinase inhibitor activity / outflow tract morphogenesis / cilium assembly / positive regulation of osteoblast differentiation / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of phosphorylation / tumor necrosis factor-mediated signaling pathway / sarcomere / phosphatidylinositol 3-kinase/protein kinase B signal transduction / substrate adhesion-dependent cell spreading / cell-matrix adhesion / integrin-mediated signaling pathway / cell morphogenesis / platelet aggregation / Z disc / actin cytoskeleton / positive regulation of canonical Wnt signaling pathway / lamellipodium / actin binding / regulation of cell shape / actin cytoskeleton organization / positive regulation of canonical NF-kappaB signal transduction / protein stabilization / non-specific serine/threonine protein kinase / cadherin binding / positive regulation of protein phosphorylation / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / positive regulation of cell population proliferation / protein kinase binding / positive regulation of DNA-templated transcription / ATP binding / membrane / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function Integrin-linked protein kinase, pseudokinase domain / Parvin / Calponin-like domain / Actin-binding Protein, T-fimbrin; domain 1 / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Ankyrin repeats (3 copies) ...Integrin-linked protein kinase, pseudokinase domain / Parvin / Calponin-like domain / Actin-binding Protein, T-fimbrin; domain 1 / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.8 Å |
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Authors | Fukuda, K. / Qin, J. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | | United States |
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Citation | Journal: Nat Commun / Year: 2018 Title: Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion. Authors: Vaynberg, J. / Fukuda, K. / Lu, F. / Bialkowska, K. / Chen, Y. / Plow, E.F. / Qin, J. |
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History | Deposition | Sep 19, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 7, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 18, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.2 | Mar 13, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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