登録情報 データベース : PDB / ID : 6a95 構造の表示 ダウンロードとリンクタイトル Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a 要素Mu-diguetoxin-Dc1a Sodium channel protein PaFPC1 詳細キーワード MEMBRANE PROTEIN/TOXIN / complex / sodium channel / toxin / MEMBRANE PROTEIN / MEMBRANE PROTEIN-TOXIN complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
host cell presynaptic membrane / membrane depolarization during action potential / voltage-gated sodium channel complex / voltage-gated sodium channel activity / sodium channel regulator activity / neuronal action potential / toxin activity / axon / extracellular region 類似検索 - 分子機能 Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 - #120 / Beta/Mu-diguetoxin-1 / Spider Toxins mu-diguetoxin-1 a, b and c / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Voltage-dependent channel domain superfamily / Ion transport domain ... Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 - #120 / Beta/Mu-diguetoxin-1 / Spider Toxins mu-diguetoxin-1 a, b and c / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Voltage-dependent channel domain superfamily / Ion transport domain / Ion transport protein / Roll / Mainly Beta 類似検索 - ドメイン・相同性 Chem-9SR / Sodium channel protein PaFPC1 / Beta-diguetoxin-Dc1a 類似検索 - 構成要素生物種 Periplaneta americana (ワモンゴキブリ)Diguetia canities (クモ)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 2.6 Å 詳細データ登録者 Shen, H.Z. / li, Z.Q. / Jiang, Y. / Pan, X.J. / Wu, J.P. / Cristofori-Armstrong, B. / Smith, J.J. / Chin, Y.K.Y. / Lei, J.L. / Zhou, Q. ...Shen, H.Z. / li, Z.Q. / Jiang, Y. / Pan, X.J. / Wu, J.P. / Cristofori-Armstrong, B. / Smith, J.J. / Chin, Y.K.Y. / Lei, J.L. / Zhou, Q. / King, G.F. / Yan, N. 資金援助 中国, オーストラリア, 7件 詳細 詳細を隠す組織 認可番号 国 Ministry of Science and Technology (China) 2015CB910101 中国 Ministry of Science and Technology (China) 2016YFA0500402 中国 National Natural Science Foundation of China 31621092 中国 National Natural Science Foundation of China 31630017 中国 National Natural Science Foundation of China 31611130036 中国 Australian Research Council DP160104411 オーストラリア National Health and Medical Research Council (Australia) APP1072113 オーストラリア
引用ジャーナル : Science / 年 : 2018タイトル : Structural basis for the modulation of voltage-gated sodium channels by animal toxins.著者 : Huaizong Shen / Zhangqiang Li / Yan Jiang / Xiaojing Pan / Jianping Wu / Ben Cristofori-Armstrong / Jennifer J Smith / Yanni K Y Chin / Jianlin Lei / Qiang Zhou / Glenn F King / Nieng Yan / 要旨 : Animal toxins that modulate the activity of voltage-gated sodium (Na) channels are broadly divided into two categories-pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and ... Animal toxins that modulate the activity of voltage-gated sodium (Na) channels are broadly divided into two categories-pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and saxitoxin (STX) are responsible for puffer fish and shellfish poisoning in humans, respectively. Here, we present structures of the insect Na channel NaPaS bound to a gating modifier toxin Dc1a at 2.8 angstrom-resolution and in the presence of TTX or STX at 2.6-Å and 3.2-Å resolution, respectively. Dc1a inserts into the cleft between VSD and the pore of NaPaS, making key contacts with both domains. The structures with bound TTX or STX reveal the molecular details for the specific blockade of Na access to the selectivity filter from the extracellular side by these guanidinium toxins. The structures shed light on structure-based development of Na channel drugs. 履歴 登録 2018年7月11日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2018年8月8日 Provider : repository / タイプ : Initial release改定 1.1 2018年12月26日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation_author.identifier_ORCID改定 1.2 2019年11月6日 Group : Data collection / Other / カテゴリ : atom_sites / cellItem : _atom_sites.fract_transf_matrix[1][1] / _atom_sites.fract_transf_matrix[2][2] ... _atom_sites.fract_transf_matrix[1][1] / _atom_sites.fract_transf_matrix[2][2] / _atom_sites.fract_transf_matrix[3][3] / _cell.Z_PDB 改定 2.0 2020年7月29日 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation
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