Entry Database : PDB / ID : 5fg6 Structure visualization Downloads & linksTitle Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe ComponentsBromodomain-containing protein 1 Details Keywords TRANSCRIPTION / MOZ-MORF complexFunction / homology Function and homology informationFunction Domain/homology Component
histone H3-K14 acetyltransferase complex / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone reader activity / erythrocyte maturation / response to immobilization stress / response to electrical stimulus / Regulation of TP53 Activity through Acetylation / positive regulation of erythrocyte differentiation ... histone H3-K14 acetyltransferase complex / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone reader activity / erythrocyte maturation / response to immobilization stress / response to electrical stimulus / Regulation of TP53 Activity through Acetylation / positive regulation of erythrocyte differentiation / HATs acetylate histones / histone binding / perikaryon / chromatin remodeling / nuclear speck / dendrite / regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / nucleus / metal ion binding Similarity search - Function BRPF2, ePHD domain / BRPF2, PHD domain / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif ... BRPF2, ePHD domain / BRPF2, PHD domain / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Zinc finger, PHD-type, conserved site / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.1 Å DetailsAuthors Tallant, C. / Owen, D.R. / Gerstenberger, B.S. / Savitsky, P. / Chaikuad, A. / Fedorov, O. / Nunez-Alonso, G. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C.H. ...Tallant, C. / Owen, D.R. / Gerstenberger, B.S. / Savitsky, P. / Chaikuad, A. / Fedorov, O. / Nunez-Alonso, G. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Muller, S. / Knapp, S. CitationJournal : To Be Published Title : Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probeAuthors: Tallant, C. / Owen, D.R. / Gerstenberger, B.S. / Savitsky, P. / Chaikuad, A. / Fedorov, O. / Nunez-Alonso, G. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / ... Authors : Tallant, C. / Owen, D.R. / Gerstenberger, B.S. / Savitsky, P. / Chaikuad, A. / Fedorov, O. / Nunez-Alonso, G. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Muller, S. / Knapp, S. History Deposition Dec 20, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Feb 3, 2016 Provider : repository / Type : Initial releaseRevision 2.0 Jan 10, 2024 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Refinement description Category : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _atom_site.occupancy / _database_2.pdbx_DOI / _database_2.pdbx_database_accession