Entry Database : PDB / ID : 5ant Structure visualization Downloads & linksTitle Potent and selective inhibitors of MTH1 probe its role in cancer cell survival Components7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Details Keywords HYDROLASE / MTH1 / ONCOLOGY / NUCLEOTIDE HYDROLYSIS / INHIBITIONFunction / homology Function and homology informationFunction Domain/homology Component
2-hydroxy-ATP hydrolase activity / 2-hydroxy-dATP hydrolase activity / N6-methyl-(d)ATP hydrolase activity / O6-methyl-dGTP hydrolase activity / 2-hydroxy-dATP diphosphatase / dATP diphosphatase activity / ATP diphosphatase activity / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity ... 2-hydroxy-ATP hydrolase activity / 2-hydroxy-dATP hydrolase activity / N6-methyl-(d)ATP hydrolase activity / O6-methyl-dGTP hydrolase activity / 2-hydroxy-dATP diphosphatase / dATP diphosphatase activity / ATP diphosphatase activity / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / Phosphate bond hydrolysis by NUDT proteins / purine nucleoside catabolic process / snoRNA binding / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / response to cadmium ion / acrosomal vesicle / male gonad development / nuclear membrane / response to oxidative stress / mitochondrial matrix / DNA repair / mitochondrion / extracellular space / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily ... Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Kettle, J.G. / Alwan, H. / Bista, M. / Breed, J. / Kack, H. / Eckersley, K. / Foote, K.M. / Fillery, S. / Goodwin, L. / Jones, D. ...Kettle, J.G. / Alwan, H. / Bista, M. / Breed, J. / Kack, H. / Eckersley, K. / Foote, K.M. / Fillery, S. / Goodwin, L. / Jones, D. / Lau, A. / Nissink, J.W.M. / Read, J. / Scott, J. / Taylor, B. / Walker, G. / Wissler, L. CitationJournal : J.Med.Chem. / Year : 2016Title : Potent and Selective Inhibitors of Mth1 Probe its Role in Cancer Cell Survival.Authors: Kettle, J.G. / Alwan, H. / Bista, M. / Breed, J. / Davies, N.L. / Eckersley, K. / Fillery, S. / Foote, K.M. / Goodwin, L. / Jones, D.R. / Kack, H. / Lau, A. / Nissink, J.W. / Read, J. / ... Authors : Kettle, J.G. / Alwan, H. / Bista, M. / Breed, J. / Davies, N.L. / Eckersley, K. / Fillery, S. / Foote, K.M. / Goodwin, L. / Jones, D.R. / Kack, H. / Lau, A. / Nissink, J.W. / Read, J. / Scott, J.S. / Taylor, B. / Walker, G. / Wissler, L. / Wylot, M. History Deposition Sep 8, 2015 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 2, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Apr 6, 2016 Group : Database referencesRevision 1.2 Aug 30, 2017 Group : Data collection / Category : diffrn_detector / reflns / reflns_shellItem : _diffrn_detector.type / _reflns.pdbx_Rmerge_I_obs / _reflns_shell.Rmerge_I_obsRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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