登録情報 | データベース: PDB / ID: 5ad2 |
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タイトル | Bivalent binding to BET bromodomains |
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要素 | BROMODOMAIN-CONTAINING PROTEIN 4 |
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キーワード | TRANSCRIPTION |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.01 Å |
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データ登録者 | Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Dale, I. / Daniels, D. ...Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Dale, I. / Daniels, D. / Flavell, L. / Holdgate, G. / Jowitt, T.A. / Kikhney, A. / McAlister, M. / Ogg, D. / Patel, J. / Petteruti, P. / Robb, G.R. / Robers, M. / Stratton, N. / Svergun, D.I. / Wang, W. / Whittaker, D. |
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引用 | ジャーナル: Nat.Chem.Biol. / 年: 2016 タイトル: Potent and Selective Bivalent Inhibitors of Bet Bromodomains 著者: Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Clark, E. / Dale, I. / Daniels, D.L. / Dulak, A. / Flavell, L. / Holdgate, G. / ...著者: Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Clark, E. / Dale, I. / Daniels, D.L. / Dulak, A. / Flavell, L. / Holdgate, G. / Jowitt, T.A. / Kikhney, A. / Mcalister, M. / Ogg, D. / Patel, J. / Petteruti, P. / Robb, G.R. / Robers, M.B. / Saif, S. / Stratton, N. / Svergun, D.I. / Wang, W. / Whittaker, D. / Wilson, D.M. / Yao, Y. |
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履歴 | 登録 | 2015年8月19日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2016年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月26日 | Group: Database references |
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改定 1.2 | 2016年11月9日 | Group: Database references |
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改定 1.3 | 2016年11月30日 | Group: Database references |
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改定 1.4 | 2024年1月10日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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