Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Journal, issue, pages	Nat. Chem. Biol., Vol. 12, Page 1097-, Year 2016
Publish date	Aug 19, 2015 (structure data deposition date)
Authors	Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Clark, E. / Dale, I. ...Waring, M.J. / Chen, H. / Rabow, A.A. / Walker, G. / Bobby, R. / Boiko, S. / Bradbury, R.H. / Callis, R. / Clark, E. / Dale, I. / Daniels, D.L. / Dulak, A. / Flavell, L. / Holdgate, G. / Jowitt, T.A. / Kikhney, A. / Mcalister, M. / Ogg, D. / Patel, J. / Petteruti, P. / Robb, G.R. / Robers, M.B. / Saif, S. / Stratton, N. / Svergun, D.I. / Wang, W. / Whittaker, D. / Wilson, D.M. / Yao, Y.
External links	Nat. Chem. Biol. / PubMed:27775716
Methods	X-ray diffraction
Resolution	1.49 - 2.01 Å
Structure data	PDB-5ad2: Bivalent binding to BET bromodomains Method: X-RAY DIFFRACTION / Resolution: 2.01 Å PDB-5ad3: Bivalent binding to BET bromodomains Method: X-RAY DIFFRACTION / Resolution: 1.49 Å
Chemicals	ChemComp-ETU: (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone ChemComp-HOH: WATER ChemComp-K6K: 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Source	homo sapiens (human)
Keywords	TRANSCRIPTION