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- EMDB-51134: human 40S ribosome bound by a SKI238-exosome complex -

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基本情報

登録情報
データベース: EMDB / ID: EMD-51134
タイトルhuman 40S ribosome bound by a SKI238-exosome complex
マップデータ
試料
  • 複合体: human 40S ribosome bound by a SKI238-exosome complex
    • RNA: x 2種
    • タンパク質・ペプチド: x 48種
キーワードRNA-binding / RNA-degradation / cytoplasm / helicase / RIBOSOME
機能・相同性
機能・相同性情報


DNA deamination / nucleolar exosome (RNase complex) / exoribonuclease II / exoribonuclease II activity / Dom34-Hbs1 complex / nuclear-transcribed mRNA catabolic process, no-go decay / U1 snRNA 3'-end processing / Ski complex / U5 snRNA 3'-end processing / TRAMP-dependent tRNA surveillance pathway ...DNA deamination / nucleolar exosome (RNase complex) / exoribonuclease II / exoribonuclease II activity / Dom34-Hbs1 complex / nuclear-transcribed mRNA catabolic process, no-go decay / U1 snRNA 3'-end processing / Ski complex / U5 snRNA 3'-end processing / TRAMP-dependent tRNA surveillance pathway / mRNA decay by 3' to 5' exoribonuclease / CUT catabolic process / cytoplasmic exosome (RNase complex) / U4 snRNA 3'-end processing / nuclear polyadenylation-dependent rRNA catabolic process / Cdc73/Paf1 complex / poly(A)-dependent snoRNA 3'-end processing / exosome (RNase complex) / nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay / nuclear exosome (RNase complex) / negative regulation of myeloid cell differentiation / exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / ATF4 activates genes in response to endoplasmic reticulum stress / histone mRNA catabolic process / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / rRNA catabolic process / 3'-5' RNA helicase activity / nuclear mRNA surveillance / positive regulation of isotype switching / ribosome disassembly / 7S RNA binding / : / negative regulation of endoplasmic reticulum unfolded protein response / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / protein tyrosine kinase inhibitor activity / positive regulation of respiratory burst involved in inflammatory response / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / mRNA 3'-UTR AU-rich region binding / positive regulation of gastrulation / nucleolus organization / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / IRE1-RACK1-PP2A complex / positive regulation of endodeoxyribonuclease activity / isotype switching / positive regulation of Golgi to plasma membrane protein transport / TNFR1-mediated ceramide production / negative regulation of RNA splicing / negative regulation of DNA repair / RNA catabolic process / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / supercoiled DNA binding / oxidized purine DNA binding / NF-kappaB complex / neural crest cell differentiation / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / positive regulation of ubiquitin-protein transferase activity / negative regulation of phagocytosis / rRNA modification in the nucleus and cytosol / erythrocyte homeostasis / Formation of the ternary complex, and subsequently, the 43S complex / cytoplasmic side of rough endoplasmic reticulum membrane / laminin receptor activity / pigmentation / protein kinase A binding / negative regulation of ubiquitin protein ligase activity / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / KSRP (KHSRP) binds and destabilizes mRNA / Ribosomal scanning and start codon recognition / ion channel inhibitor activity / maturation of 5.8S rRNA / Translation initiation complex formation / nuclear chromosome / mammalian oogenesis stage / positive regulation of mitochondrial depolarization / activation-induced cell death of T cells / positive regulation of T cell receptor signaling pathway / iron-sulfur cluster binding / fibroblast growth factor binding / negative regulation of Wnt signaling pathway / positive regulation of activated T cell proliferation / monocyte chemotaxis / Protein hydroxylation / negative regulation of peptidyl-serine phosphorylation / regulation of cell division / Association of TriC/CCT with target proteins during biosynthesis / BH3 domain binding / SARS-CoV-1 modulates host translation machinery / mTORC1-mediated signalling / mRNA catabolic process / Peptide chain elongation / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / cysteine-type endopeptidase activator activity involved in apoptotic process / Selenocysteine synthesis / positive regulation of signal transduction by p53 class mediator / nuclear-transcribed mRNA catabolic process / Formation of a pool of free 40S subunits
類似検索 - 分子機能
Exosome complex component Rrp43 / : / Mammalian exosome complex component RRP40, N-terminal / HBS1-like protein, N-terminal domain superfamily / Ski3/TTC37 / HBS1-like protein, N-terminal / HBS1 N-terminus / Ski2, N-terminal domain / Ski2 N-terminal region / Exosome complex exonuclease RRP44, S1 domain ...Exosome complex component Rrp43 / : / Mammalian exosome complex component RRP40, N-terminal / HBS1-like protein, N-terminal domain superfamily / Ski3/TTC37 / HBS1-like protein, N-terminal / HBS1 N-terminus / Ski2, N-terminal domain / Ski2 N-terminal region / Exosome complex exonuclease RRP44, S1 domain / S1 domain / Exosome complex component RRP45 / Rrp40, S1 domain / : / Exosome complex component RRP40, S1 domain / Exosome complex component CSL4, C-terminal / Exosome complex component, N-terminal domain / Exosome complex component Csl4 / Exosome component EXOSC1/CSL4 / Exosome complex exonuclease RRP4 N-terminal region / RRP4, S1 domain / : / Rrp44-like cold shock domain / Rrp44-like cold shock domain / : / KH domain / Exosome complex RNA-binding protein 1/RRP40/RRP4 / Dis3-like cold-shock domain 2 / Dis3-like cold-shock domain 2 (CSD2) / : / Ribonuclease II/R, conserved site / rRNA-processing arch domain / Ribonuclease II family signature. / Mtr4-like, beta-barrel domain / : / Ribonuclease II/R / RNB domain / RNB / : / ATP-dependent RNA helicase Ski2, C-terminal / ATP-dependent RNA helicase Ski2-like / : / DSHCT (NUC185) domain / Exosome RNA helicase MTR4-like, stalk / DSHCT / : / GTP-eEF1A C-terminal domain-like / Exoribonuclease, phosphorolytic domain 2 / 3' exoribonuclease family, domain 2 / Exoribonuclease, phosphorolytic domain 1 / PNPase/RNase PH domain superfamily / Exoribonuclease, PH domain 2 superfamily / 3' exoribonuclease family, domain 1 / : / Tetratricopeptide repeat / K Homology domain, type 1 / Tetratricopeptide repeat / 40S ribosomal protein SA / K Homology domain, type 1 superfamily / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ubiquitin-like protein FUBI / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / Tetratricopeptide repeat / : / Ribosomal protein S26e signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S26e / Ribosomal protein S21e, conserved site / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S21e signature. / : / Ribosomal protein S12e signature. / Ribosomal protein S12e / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein S2, eukaryotic / Small (40S) ribosomal subunit Asc1/RACK1 / S27a-like superfamily / 40S Ribosomal protein S10 / Ribosomal protein S10, eukaryotic/archaeal / Plectin/S10, N-terminal / Plectin/S10 domain / Ribosomal protein S25 / S25 ribosomal protein / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S2, eukaryotic/archaeal / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein S30 / :
類似検索 - ドメイン・相同性
Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 ...Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein eS4, X isoform / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Exosome complex component RRP45 / Exosome complex component RRP4 / Exosome complex component RRP42 / Superkiller complex protein 2 / Exosome complex component MTR3 / Superkiller complex protein 3 / DIS3-like exonuclease 1 / Exosome complex component RRP43 / Superkiller complex protein 8 / Exosome complex component RRP41 / Exosome complex component RRP46 / Exosome complex component RRP40 / Exosome complex component CSL4 / HBS1-like protein
類似検索 - 構成要素
生物種Homo sapiens (ヒト) / Cricket paralysis virus (ウイルス)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.4 Å
データ登録者Koegel A / Keidel A / Loukeri MJ / Kuhn CC / Langer LM / Schaefer IB / Conti E
資金援助 ドイツ, European Union, デンマーク, 5件
OrganizationGrant number
Max Planck Society ドイツ
European Research Council (ERC)740329European Union
European Research Council (ERC)101054447European Union
German Research Foundation (DFG)SFB1035 ドイツ
Novo Nordisk Foundation31199 デンマーク
引用ジャーナル: Nature / : 2024
タイトル: Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
著者: Alexander Kögel / Achim Keidel / Matina-Jasemi Loukeri / Christopher C Kuhn / Lukas M Langer / Ingmar B Schäfer / Elena Conti /
要旨: The interplay between translation and mRNA decay is widespread in human cells. In quality-control pathways, exonucleolytic degradation of mRNA associated with translating ribosomes is mediated ...The interplay between translation and mRNA decay is widespread in human cells. In quality-control pathways, exonucleolytic degradation of mRNA associated with translating ribosomes is mediated largely by the cytoplasmic exosome, which includes the exoribonuclease complex EXO10 and the helicase complex SKI238 (refs. ). The helicase can extract mRNA from the ribosome and is expected to transfer it to the exoribonuclease core through a bridging factor, HBS1L3 (also known as SKI7), but the mechanisms of this molecular handover remain unclear. Here we reveal how human EXO10 is recruited by HBS1L3 (SKI7) to an active ribosome-bound SKI238 complex. We show that rather than a sequential handover, a direct physical coupling mechanism takes place, which culminates in the formation of a cytoplasmic exosome-ribosome supercomplex. Capturing the structure during active decay reveals a continuous path in which an RNA substrate threads from the 80S ribosome through the SKI2 helicase into the exoribonuclease active site of the cytoplasmic exosome complex. The SKI3 subunit of the complex directly binds to HBS1L3 (SKI7) and also engages a surface of the 40S subunit, establishing a recognition platform in collided disomes. Exosome and ribosome thus work together as a single structural and functional unit in co-translational mRNA decay, coordinating their activities in a transient supercomplex.
履歴
登録2024年7月23日-
ヘッダ(付随情報) 公開2024年10月16日-
マップ公開2024年10月16日-
更新2024年10月23日-
現状2024年10月23日処理サイト: PDBe / 状態: 公開

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構造の表示

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マップ

ファイルダウンロード / ファイル: emd_51134.map.gz / 形式: CCP4 / 大きさ: 2.1 GB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
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画像のコントロール

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明度
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Z (Sec.)Y (Row.)X (Col.)
0.85 Å/pix.
x 832 pix.
= 708.198 Å
0.85 Å/pix.
x 832 pix.
= 708.198 Å
0.85 Å/pix.
x 832 pix.
= 708.198 Å

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画像は Spider により作成

ボクセルのサイズX=Y=Z: 0.8512 Å
密度
表面レベル登録者による: 0.01
最小 - 最大-0.012958453 - 0.05347155
平均 (標準偏差)0.000065772525 (±0.0009892983)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ832832832
Spacing832832832
セルA=B=C: 708.19836 Å
α=β=γ: 90.0 °

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添付データ

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マスク #1

ファイルemd_51134_msk_1.map
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追加マップ: composite map human 40S ribosome bound to the...

ファイルemd_51134_additional_1.map
注釈composite map human 40S ribosome bound to the SKI238 complex and the exosome
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ファイルemd_51134_half_map_1.map
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ハーフマップ: #1

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試料の構成要素

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全体 : human 40S ribosome bound by a SKI238-exosome complex

全体名称: human 40S ribosome bound by a SKI238-exosome complex
要素
  • 複合体: human 40S ribosome bound by a SKI238-exosome complex
    • RNA: CrPV-IRES RNA
    • タンパク質・ペプチド: 40S ribosomal protein S16
    • タンパク質・ペプチド: 40S ribosomal protein S17
    • タンパク質・ペプチド: 40S ribosomal protein S18
    • タンパク質・ペプチド: 40S ribosomal protein S19
    • タンパク質・ペプチド: 40S ribosomal protein S20
    • タンパク質・ペプチド: 40S ribosomal protein S21
    • タンパク質・ペプチド: 40S ribosomal protein S23
    • タンパク質・ペプチド: 40S ribosomal protein S26
    • タンパク質・ペプチド: 40S ribosomal protein S28
    • タンパク質・ペプチド: 60S ribosomal protein L41
    • タンパク質・ペプチド: 40S ribosomal protein S29
    • タンパク質・ペプチド: Ubiquitin
    • タンパク質・ペプチド: Receptor of activated protein C kinase 1
    • タンパク質・ペプチド: 40S ribosomal protein S2
    • タンパク質・ペプチド: 40S ribosomal protein S6
    • RNA: 18S ribosomal RNA
    • タンパク質・ペプチド: 40S ribosomal protein S9
    • タンパク質・ペプチド: 40S ribosomal protein S12
    • タンパク質・ペプチド: 40S ribosomal protein SA
    • タンパク質・ペプチド: 40S ribosomal protein S13
    • タンパク質・ペプチド: 40S ribosomal protein S3a
    • タンパク質・ペプチド: 40S ribosomal protein S14
    • タンパク質・ペプチド: 40S ribosomal protein S3
    • タンパク質・ペプチド: 40S ribosomal protein S15a
    • タンパク質・ペプチド: 40S ribosomal protein S4, X isoform
    • タンパク質・ペプチド: 40S ribosomal protein S24
    • タンパク質・ペプチド: Helicase SKI2W
    • タンパク質・ペプチド: Superkiller complex protein 3
    • タンパク質・ペプチド: WD repeat-containing protein 61
    • タンパク質・ペプチド: 40S ribosomal protein S5
    • タンパク質・ペプチド: 40S ribosomal protein S25
    • タンパク質・ペプチド: Exosome complex component RRP42
    • タンパク質・ペプチド: Exosome complex component MTR3
    • タンパク質・ペプチド: Exosome complex component RRP40
    • タンパク質・ペプチド: Exosome complex component RRP4
    • タンパク質・ペプチド: Exosome complex component CSL4
    • タンパク質・ペプチド: Exosome complex component RRP45
    • タンパク質・ペプチド: Isoform 2 of HBS1-like protein
    • タンパク質・ペプチド: DIS3-like exonuclease 1
    • タンパク質・ペプチド: Exosome complex component RRP43
    • タンパク質・ペプチド: Exosome complex component RRP41
    • タンパク質・ペプチド: Exosome complex component RRP46
    • タンパク質・ペプチド: 40S ribosomal protein S7
    • タンパク質・ペプチド: 40S ribosomal protein S27
    • タンパク質・ペプチド: 40S ribosomal protein S8
    • タンパク質・ペプチド: 40S ribosomal protein S30
    • タンパク質・ペプチド: 40S ribosomal protein S10
    • タンパク質・ペプチド: 40S ribosomal protein S11
    • タンパク質・ペプチド: 40S ribosomal protein S15

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超分子 #1: human 40S ribosome bound by a SKI238-exosome complex

超分子名称: human 40S ribosome bound by a SKI238-exosome complex
タイプ: complex / ID: 1 / 親要素: 0
含まれる分子: #14, #34-#39, #41, #44, #46, #15, #47, #49-#50, #20, #24, #17, #27, #30, #18, #31, #19, #32, #21, #40, #22, #42, #9, #1-#2, #23, #43, #3, #11-#13, #4-#5, #10, #16, #6-#8, #25, ...含まれる分子: #14, #34-#39, #41, #44, #46, #15, #47, #49-#50, #20, #24, #17, #27, #30, #18, #31, #19, #32, #21, #40, #22, #42, #9, #1-#2, #23, #43, #3, #11-#13, #4-#5, #10, #16, #6-#8, #25, #45, #26, #48, #28-#29, #33
由来(天然)生物種: Homo sapiens (ヒト)

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分子 #1: Superkiller complex protein 3

分子名称: Superkiller complex protein 3 / タイプ: protein_or_peptide / ID: 1 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 176.06475 KDa
組換発現生物種: Spodoptera frugiperda (ツマジロクサヨトウ)
配列文字列: GPDSMSSKEV KTALKSARDA IRNKEYKEAL KHCKTVLKQE KNNYNAWVFI GVAAAELEQP DQAQSAYKKA AELEPDQLLA WQGLANLYE KYNHINAKDD LPGVYQKLLD LYESVDKQKW CDVCKKLVDL YYQEKKHLEV ARTWHKLIKT RQEQGAENEE L HQLWRKLT ...文字列:
GPDSMSSKEV KTALKSARDA IRNKEYKEAL KHCKTVLKQE KNNYNAWVFI GVAAAELEQP DQAQSAYKKA AELEPDQLLA WQGLANLYE KYNHINAKDD LPGVYQKLLD LYESVDKQKW CDVCKKLVDL YYQEKKHLEV ARTWHKLIKT RQEQGAENEE L HQLWRKLT QFLAESTEDQ NNETQQLLFT AFENALGLSD KIPSEDHQVL YRHFIQSLSK FPHESARLKK ACEGMINIYP TV QYPLEVL CLHLIESGNL TDEGQQYCCR LVEMDSKSGP GLIGLGIKAL QDKKYEDAVR NLTEGLKESP VCTSGWYHLA EAQ VKMHRP KEAVLSCSQA LKIVDNLGAS GNSLYQRNLC LHLKAEALIK LSDYDSSEEA IRTLDQISDA DNIPGLLVLK SLAY RNKGS FDEAAKIMED LLSSYPDLAE VHALEALIHF TKKDYLQAEK CFQRALEKDT EVAEYHYQLG LTYWFMGEET RKDKT KALT HFLKAARLDT YMGKVFCYLG HYYRDVVGDK NRARGCYRKA FELDDTDAES GAAAVDLSVE LEDMEMALAI LTTVTQ KAS AGTAKWAWLR RGLYYLKAGQ HSQAVADLQA ALRADPKDFN CWESLGEAYL SRGGYTTALK SFTKASELNP ESIYSVF KV AAIQQILGKY KEAVAQYQMI IKKKEDYVPA LKGLGECHLM MAKAALVDYL DGKAVDYIEK ALEYFTCALQ HRADVSCL W KLAGDACTCL YAVAPSKVNV HVLGVLLGQK EGKQVLKKNE LLHLGGRCYG RALKLMSTSN TWCDLGINYY RQAQHLAET GSNMNDLKEL LEKSLHCLKK AVRLDSNNHL YWNALGVVAC YSGIGNYALA QHCFIKSIQS EQINAVAWTN LGVLYLTNEN IEQAHEAFK MAQSLDPSYL MCWIGQALIA EAVGSYDTMD LFRHTTELNM HTEGALGYAY WVCTTLQDKS NRETELYQYN I LQMNAIPA AQVILNKYVE RIQNYAPAFT MLGYLNEHLQ LKKEAANAYQ RAILLLQTAE DQDTYNVAIR NYGRLLCSTG EY DKAIQAF KSTPLEVLED IIGFALALFM KGLYKESSKA YERALSIVES EQDKAHILTA LAITEYKQGK TDVAKTLLFK CSI LKEPTT ESLQALCALG LAMQDATLSK AALNELLKHI KHKDSNYQRC LLTSAIYALQ GRSVAVQKQI SKAVHSNPGD PALW SLLSR VVAQYAQRNA KGGVVAGNVA HILDSNHGKK ALLYTAVNQL AMGSSSAEDE KNTALKTIQK AALLSPGDPA IWAGL MAAC HADDKLALVN NTQPKRIDLY LALLSAVSAS IKDEKFFENY NQSLEKWSLS QAVTGLIDTG RISEAETLCT KNLKSN PDQ PAVILLLRQV QCKPLLESQK PLPDAVLEEL QKTVMSNSTS VPAWQWLAHV YQSQGMMRAA EMCYRKSLQL ASQRGSW SG KLSSLLRLAL LALKVCMANI SNDHWPSLVQ EATTEALKLC FCPLAVLLQA LLQFKRKMGA RETRRLLERV VYQPGYPK S IASTARWYLL RHLYAKDDYE LIDVLVNNAK THGDTRALEL NQRLSSQ

UniProtKB: Superkiller complex protein 3

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分子 #2: WD repeat-containing protein 61

分子名称: WD repeat-containing protein 61 / タイプ: protein_or_peptide / ID: 2 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 33.617465 KDa
組換発現生物種: Spodoptera frugiperda (ツマジロクサヨトウ)
配列文字列: MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIR LWDLENGKQI KSIDAGPVDA WTLAFSPDSQ YLATGTHVGK VNIFGVESGK KEYSLDTRGK FILSIAYSPD G KYLASGAI ...文字列:
MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIR LWDLENGKQI KSIDAGPVDA WTLAFSPDSQ YLATGTHVGK VNIFGVESGK KEYSLDTRGK FILSIAYSPD G KYLASGAI DGIINIFDIA TGKLLHTLEG HAMPIRSLTF SPDSQLLVTA SDDGYIKIYD VQHANLAGTL SGHASWVLNV AF CPDDTHF VSSSSDKSVK VWDVGTRTCV HTFFDHQDQV WGVKYNGNGS KIVSVGDDQE IHIYDCPI

UniProtKB: Superkiller complex protein 8

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分子 #3: Exosome complex component RRP42

分子名称: Exosome complex component RRP42 / タイプ: protein_or_peptide / ID: 3 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 32.216762 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMASVTL SEAEKVYIVH GVQEDLRVDG RGCEDYRCVE VETDVVSNTS GSARVKLGHT DILVGVKAEM GTPKLEKPNE GYLEFFVDC SASATPEFEG RGGDDLGTEI ANTLYRIFNN KSSVDLKTLC ISPREHCWVL YVDVLLLECG GNLFDAISIA V KAALFNTR ...文字列:
GPDSMASVTL SEAEKVYIVH GVQEDLRVDG RGCEDYRCVE VETDVVSNTS GSARVKLGHT DILVGVKAEM GTPKLEKPNE GYLEFFVDC SASATPEFEG RGGDDLGTEI ANTLYRIFNN KSSVDLKTLC ISPREHCWVL YVDVLLLECG GNLFDAISIA V KAALFNTR IPRVRVLEDE EGSKDIELSD DPYDCIRLSV ENVPCIVTLC KIGYRHVVDA TLQEEACSLA SLLVSVTSKG VV TCMRKVG KGSLDPESIF EMMETGKRVG KVLHASLQSV VHKEESLGPK RQKVGFLG

UniProtKB: Exosome complex component RRP42

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分子 #4: Exosome complex component CSL4

分子名称: Exosome complex component CSL4 / タイプ: protein_or_peptide / ID: 4 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 21.8351 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMAPPVR YCIPGERLCN LEEGSPGSGT YTRHGYIFSS LAGCLMKSSE NGALPVVSVV RETESQLLPD VGAIVTCKVS SINSRFAKV HILYVGSMPL KNSFRGTIRK EDVRATEKDK VEIYKSFRPG DIVLAKVISL GDAQSNYLLT TAENELGVVV A HSESGIQM ...文字列:
GPDSMAPPVR YCIPGERLCN LEEGSPGSGT YTRHGYIFSS LAGCLMKSSE NGALPVVSVV RETESQLLPD VGAIVTCKVS SINSRFAKV HILYVGSMPL KNSFRGTIRK EDVRATEKDK VEIYKSFRPG DIVLAKVISL GDAQSNYLLT TAENELGVVV A HSESGIQM VPISWCEMQC PKTHTKEFRK VARVQPEFLQ T

UniProtKB: Exosome complex component CSL4

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分子 #5: Exosome complex component RRP45

分子名称: Exosome complex component RRP45 / タイプ: protein_or_peptide / ID: 5 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 49.370312 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMKETPL SNCERRFLLR AIEEKKRLDG RQTYDYRNIR ISFGTDYGCC IVELGKTRVL GQVSCELVSP KLNRATEGIL FFNLELSQM AAPAFEPGRQ SDLLVKLNRL MERCLRNSKC IDTESLCVVA GEKVWQIRVD LHLLNHDGNI IDAASIAAIV A LCHFRRPD ...文字列:
GPDSMKETPL SNCERRFLLR AIEEKKRLDG RQTYDYRNIR ISFGTDYGCC IVELGKTRVL GQVSCELVSP KLNRATEGIL FFNLELSQM AAPAFEPGRQ SDLLVKLNRL MERCLRNSKC IDTESLCVVA GEKVWQIRVD LHLLNHDGNI IDAASIAAIV A LCHFRRPD VSVQGDEVTL YTPEERDPVP LSIHHMPICV SFAFFQQGTY LLVDPNEREE RVMDGLLVIA MNKHREICTI QS SGGIMLL KDQVLRCSKI AGVKVAEITE LILKALENDQ KVRKEGGKFG FAESIANQRI TAFKMEKAPI DTSDVEEKAE EII AEAEPP SEVVSTPVLW TPGTAQIGEG VENSWGDLED SEKEDDEGGG DQAIILDGIK MDTGVEVSDI GSQDAPIILS DSEE EEMII LEPDKNPKKI RTQTTSAKQE KAPSKKPVKR RKKKRAAN

UniProtKB: Exosome complex component RRP45

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分子 #6: Exosome complex component RRP43

分子名称: Exosome complex component RRP43 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 30.429893 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMAAGFK TVEPLEYYRR FLKENCRPDG RELGEFRTTT VNIGSISTAD GSALVKLGNT TVICGVKAEF AAPSTDAPDK GYVVPNVDL PPLCSSRFRS GPPGEEAQVA SQFIADVIEN SQIIQKEDLC ISPGKLVWVL YCDLICLDYD GNILDACTFA L LAALKNVQ ...文字列:
GPDSMAAGFK TVEPLEYYRR FLKENCRPDG RELGEFRTTT VNIGSISTAD GSALVKLGNT TVICGVKAEF AAPSTDAPDK GYVVPNVDL PPLCSSRFRS GPPGEEAQVA SQFIADVIEN SQIIQKEDLC ISPGKLVWVL YCDLICLDYD GNILDACTFA L LAALKNVQ LPEVTINEET ALAEVNLKKK SYLNIRTHPV ATSFAVFDDT LLIVDPTGEE EHLATGTLTI VMDEEGKLCC LH KPGGSGL TGAKLQDCMS RAVTRHKEVK KLMDEVIKSM KPK

UniProtKB: Exosome complex component RRP43

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分子 #7: Exosome complex component RRP41

分子名称: Exosome complex component RRP41 / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 26.416996 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: MAGLELLSDQ GYRVDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA VVYGPHEIRG SRARALPDRA LVNCQYSSAT FSTGERKRR PHGDRKSCEM GLQLRQTFEA AILTQLHPRS QIDIYVQVLQ ADGGTYAACV NAATLAVLDA GIPMRDFVCA C SAGFVDGT ...文字列:
MAGLELLSDQ GYRVDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA VVYGPHEIRG SRARALPDRA LVNCQYSSAT FSTGERKRR PHGDRKSCEM GLQLRQTFEA AILTQLHPRS QIDIYVQVLQ ADGGTYAACV NAATLAVLDA GIPMRDFVCA C SAGFVDGT ALADLSHVEE AAGGPQLALA LLPASGQIAL LEMDARLHED HLERVLEAAA QAARDVHTLL DRVVRQHVRE AS ILLGD

UniProtKB: Exosome complex component RRP41

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分子 #8: Exosome complex component RRP46

分子名称: Exosome complex component RRP46 / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 25.636312 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMEEETH TDAKIRAENG TGSSPRGPGC SLRHFACEQN LLSRPDGSAS FLQGDTSVLA GVYGPAEVKV SKEIFNKATL EVILRPKIG LPGVAEKSRE RLIRNTCEAV VLGTLHPRTS ITVVLQVVSD AGSLLACCLN AACMALVDAG VPMRALFCGV A CALDSDGT ...文字列:
GPDSMEEETH TDAKIRAENG TGSSPRGPGC SLRHFACEQN LLSRPDGSAS FLQGDTSVLA GVYGPAEVKV SKEIFNKATL EVILRPKIG LPGVAEKSRE RLIRNTCEAV VLGTLHPRTS ITVVLQVVSD AGSLLACCLN AACMALVDAG VPMRALFCGV A CALDSDGT LVLDPTSKQE KEARAVLTFA LDSVERKLLM SSTKGLYSDT ELQQCLAAAQ AASQHVFRFY RESLQRRYSK S

UniProtKB: Exosome complex component RRP46

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分子 #9: Helicase SKI2W

分子名称: Helicase SKI2W / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
EC番号: 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 137.913688 KDa
組換発現生物種: Spodoptera frugiperda (ツマジロクサヨトウ)
配列文字列: MMETERLVLP PPDPLDLPLR AVELGCTGHW ELLNLPGAPE SSLPHGLPPC APDLQQEAEQ LFLSSPAWLP LHGVEHSARK WQRKTDPWS LLAVLGAPVP SDLQAQRHPT TGQILGYKEV LLENTNLSAT TSLSLRRPPG PASQSLWGNP TQYPFWPGGM D EPTITDLN ...文字列:
MMETERLVLP PPDPLDLPLR AVELGCTGHW ELLNLPGAPE SSLPHGLPPC APDLQQEAEQ LFLSSPAWLP LHGVEHSARK WQRKTDPWS LLAVLGAPVP SDLQAQRHPT TGQILGYKEV LLENTNLSAT TSLSLRRPPG PASQSLWGNP TQYPFWPGGM D EPTITDLN TREEAEEEID FEKDLLTIPP GFKKGMDFAP KDCPTPAPGL LSLSCMLEPL DLGGGDEDEN EAVGQPGGPR GD TVSASPC SAPLARASSL EDLVLKEAST AVSTPEAPEP PSQEQWAIPV DATSPVGDFY RLIPQPAFQW AFEPDVFQKQ AIL HLERHD SVFVAAHTSA GKTVVAEYAI ALAQKHMTRT IYTSPIKALS NQKFRDFRNT FGDVGLLTGD VQLHPEASCL IMTT EILRS MLYSGSDVIR DLEWVIFDEV HYINDVERGV VWEEVLIMLP DHVSIILLSA TVPNALEFAD WIGRLKRRQI YVIST VTRP VPLEHYLFTG NSSKTQGELF LLLDSRGAFH TKGYYAAVEA KKERMSKHAQ TFGAKQPTHQ GGPAQDRGVY LSLLAS LRT RAQLPVVVFT FSRGRCDEQA SGLTSLDLTT SSEKSEIHLF LQRCLARLRG SDRQLPQVLH MSELLNRGLG VHHSGIL PI LKEIVEMLFS RGLVKVLFAT ETFAMGVNMP ARTVVFDSMR KHDGSTFRDL LPGEYVQMAG RAGRRGLDPT GTVILLCK G RVPEMADLHR MMMGKPSQLQ SQFRLTYTMI LNLLRVDALR VEDMMKRSFS EFPSRKDSKA HEQALAELTK RLGALEEPD MTGQLVDLPE YYSWGEELTE TQHMIQRRIM ESVNGLKSLS AGRVVVVKNQ EHHNALGVIL QVSSNSTSRV FTTLVLCDKP LSQDPQDRG PATAEVPYPD DLVGFKLFLP EGPCDHTVVK LQPGDMAAIT TKVLRVNGEK ILEDFSKRQQ PKFKKDPPLA A VTTAVQEL LRLAQAHPAG PPTLDPVNDL QLKDMSVVEG GLRARKLEEL IQGAQCVHSP RFPAQYLKLR ERMQIQKEME RL RFLLSDQ SLLLLPEYHQ RVEVLRTLGY VDEAGTVKLA GRVACAMSSH ELLLTELMFD NALSTLRPEE IAALLSGLVC QSP GDAGDQ LPNTLKQGIE RVRAVAKRIG EVQVACGLNQ TVEEFVGELN FGLVEVVYEW ARGMPFSELA GLSGTPEGLV VRCI QRLAE MCRSLRGAAR LVGEPVLGAK METAATLLRR DIVFAASLYT Q

UniProtKB: Superkiller complex protein 2

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分子 #10: Isoform 2 of HBS1-like protein

分子名称: Isoform 2 of HBS1-like protein / タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
EC番号: 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 30.196131 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSSQCESP SLTELFQEHK ENNISQCFTL SDLCNQSSAS FTDLSLGSFP LSQLANRCQS SPGISELTGS LSSLAFHKAS PTRDLENLS LSELIAETID VDNSQIKKES FEVSLSEVRS PGIDSNIDLS VLIKNPDFVP KPVVDPSIAP SSRTKVLSSK L GKNSNFAK ...文字列:
GPDSSQCESP SLTELFQEHK ENNISQCFTL SDLCNQSSAS FTDLSLGSFP LSQLANRCQS SPGISELTGS LSSLAFHKAS PTRDLENLS LSELIAETID VDNSQIKKES FEVSLSEVRS PGIDSNIDLS VLIKNPDFVP KPVVDPSIAP SSRTKVLSSK L GKNSNFAK DNKKNNKGSL TRKPPFSLSW TKALAARPSA FASTLCLRYP LKSCKRRTLD LYKTFLYSRQ VQDVKDKEIS PL VAITPFD FKSASPDDIV KANQKKAFTR ELEVLFQ

UniProtKB: HBS1-like protein

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分子 #11: Exosome complex component MTR3

分子名称: Exosome complex component MTR3 / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 28.267127 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT KVLCAVSGPR QAEGGERGGG PAGAGGEAP AALRGRLLCD FRRAPFAGRR RRAPPGGCEE RELALALQEA LEPAVRLGRY PRAQLEVSAL LLEDGGSALA A ALTAAALA ...文字列:
MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT KVLCAVSGPR QAEGGERGGG PAGAGGEAP AALRGRLLCD FRRAPFAGRR RRAPPGGCEE RELALALQEA LEPAVRLGRY PRAQLEVSAL LLEDGGSALA A ALTAAALA LADAGVEMYD LVVGCGLSLA PGPAPTWLLD PTRLEEERAA AGLTVALMPV LNQVAGLLGS GEGGLTESWA EA VRLGLEG CQRLYPVLQQ SLVRAARRRG AAAQP

UniProtKB: Exosome complex component MTR3

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分子 #12: Exosome complex component RRP40

分子名称: Exosome complex component RRP40 / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 29.940502 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMAEPAS VAAESLAGSR ARAARTVLGQ VVLPGEELLL PEQEDAEGPG GAVERPLSLN ARACSRVRVV CGPGLRRCGD RLLVTKCGR LRHKEPGSGS GGGVYWVDSQ QKRYVPVKGD HVIGIVTAKS GDIFKVDVGG SEPASLSYLS FEGATKRNRP N VQVGDLIY ...文字列:
GPDSMAEPAS VAAESLAGSR ARAARTVLGQ VVLPGEELLL PEQEDAEGPG GAVERPLSLN ARACSRVRVV CGPGLRRCGD RLLVTKCGR LRHKEPGSGS GGGVYWVDSQ QKRYVPVKGD HVIGIVTAKS GDIFKVDVGG SEPASLSYLS FEGATKRNRP N VQVGDLIY GQFVVANKDM EPEMVCIDSC GRANGMGVIG QDGLLFKVTL GLIRKLLAPD CEIIQEVGKL HPLEIVFGMN GR IWVKAKT IQQTLILANI LEACEHMTSD QRKQIFSRLA ES

UniProtKB: Exosome complex component RRP40

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分子 #13: Exosome complex component RRP4

分子名称: Exosome complex component RRP4 / タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 33.190355 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: GPDSMAMEMR LPVARKPLSE RLGRDTKKHL VVPGDTITTD TGFMRGHGTY MGEEKLIASV AGSVERVNKL ICVKALKTRY IGEVGDIVV GRITEVQQKR WKVETNSRLD SVLLLSSMNL PGGELRRRSA EDELAMRGFL QEGDLISAEV QAVFSDGAVS L HTRSLKYG ...文字列:
GPDSMAMEMR LPVARKPLSE RLGRDTKKHL VVPGDTITTD TGFMRGHGTY MGEEKLIASV AGSVERVNKL ICVKALKTRY IGEVGDIVV GRITEVQQKR WKVETNSRLD SVLLLSSMNL PGGELRRRSA EDELAMRGFL QEGDLISAEV QAVFSDGAVS L HTRSLKYG KLGQGVLVQV SPSLVKRQKT HFHDLPCGAS VILGNNGFIW IYPTPEHKEE EAGGFIANLE PVSLADREVI SR LRNCIIS LVTQRMMLYD TSILYCYEAS LPHQIKDILK PEIMEEIVME TRQRLLEQEG

UniProtKB: Exosome complex component RRP4

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分子 #15: 60S ribosomal protein L41

分子名称: 60S ribosomal protein L41 / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 3.473451 KDa
配列文字列:
MRAKWRKKRM RRLKRKRRKM RQRSK

UniProtKB: Small ribosomal subunit protein eS32

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分子 #16: DIS3-like exonuclease 1

分子名称: DIS3-like exonuclease 1 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO / EC番号: exoribonuclease II
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 125.229984 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列: MSAWSHPQFE KGGGSGGGSG GSAWSHPQFE KTAGLEVLFQ GPMLQKREKV LLLRTFQGRT LRIVREHYLR PCVPCHSPLC PQPAACSHD GKLLSSDVTH YVIPDWKVVQ DYLEILEFPE LKGIIFMQTA CQAVQHQRGR RQYNKLRNLL KDARHDCILF A NEFQQCCY ...文字列:
MSAWSHPQFE KGGGSGGGSG GSAWSHPQFE KTAGLEVLFQ GPMLQKREKV LLLRTFQGRT LRIVREHYLR PCVPCHSPLC PQPAACSHD GKLLSSDVTH YVIPDWKVVQ DYLEILEFPE LKGIIFMQTA CQAVQHQRGR RQYNKLRNLL KDARHDCILF A NEFQQCCY LPRERGESME KWQTRSIYNA AVWYYHHCQD RMPIVMVTED EEAIQQYGSE TEGVFVITFK NYLDNFWPDL KA AHELCDS ILQSRREREN ESQESHGKEY PEHLPLEVLE AGIKSGRYIQ GILNVNKHRA QIEAFVRLQG ASSKDSDLVS DIL IHGMKA RNRSIHGDVV VVELLPKNEW KGRTVALCEN DCDDKASGES PSEPMPTGRV VGILQKNWRD YVVTFPSKEE VQSQ GKNAQ KILVTPWDYR IPKIRISTQQ AETLQDFRVV VRIDSWESTS VYPNGHFVRV LGRIGDLEGE IATILVENSI SVIPF SEAQ MCEMPVNTPE SPWKVSPEEE QKRKDLRKSH LVFSIDPKGC EDVNDTLSVR TLNNGNLELG VHIADVTHFV APNSYI DIE ARTRATTYYL ADRRYDMLPS VLSADLCSLL GGVDRYAVSI MWELDKASYE IKKVWYGRTI IRSAYKLFYE AAQELLD GN LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE LEGVEVCVQL DDKKNIHDLI PKQPLEVH E TVAECMILAN HWVAKKIWES FPHQALLRQH PPPHQEFFSE LRECAKAKGF FIDTRSNKTL ADSLDNANDP HDPIVNRLL RSMATQAMSN ALYFSTGSCA EEEFHHYGLA LDKYTHFTSP IRRYSDIVVH RLLMAAISKD KKMEIKGNLF SNKDLEELCR HINNRNQAA QHSQKQSTEL FQCMYFKDKD PATEERCISD GVIYSIRTNG VLLFIPRFGI KGAAYLKNKD GLVISCGPDS C SEWKPGSL QRFQNKITST TTDGESVTFH LFDHVTVRIS IQASRCHSDT IRLEIISNKP YKIPNTELIH QSSPLLKSEL VK EVTKSVE EAQLAQEVKV NIIQEEYQEY RQTKGRSLYT LLEEIRDLAL LDVSNNYGI

UniProtKB: DIS3-like exonuclease 1

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分子 #18: 40S ribosomal protein SA

分子名称: 40S ribosomal protein SA / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 32.883938 KDa
配列文字列: MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLK FAAATGATPI AGRFTPGTFT NQIQAAFREP RLLVVTDPRA DHQPLTEASY VNLPTIALCN TDSPLRYVDI A IPCNNKGA ...文字列:
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLK FAAATGATPI AGRFTPGTFT NQIQAAFREP RLLVVTDPRA DHQPLTEASY VNLPTIALCN TDSPLRYVDI A IPCNNKGA HSVGLMWWML AREVLRMRGT ISREHPWEVM PDLYFYRDPE EIEKEEQAAA EKAVTKEEFQ GEWTAPAPEF TA TQPEVAD WSEGVQVPSV PIQQFPTEDW SAQPATEDWS AAPTAQATEW VGATTDWS

UniProtKB: Small ribosomal subunit protein uS2

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分子 #19: 40S ribosomal protein S3a

分子名称: 40S ribosomal protein S3a / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 30.002061 KDa
配列文字列: MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITE DVQGKNCLTN FHGMDLTRDK MCSMVKKWQT MIEAHVDVKT TDGYLLRLFC VGFTKKRNNQ IRKTSYAQHQ Q VRQIRKKM ...文字列:
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITE DVQGKNCLTN FHGMDLTRDK MCSMVKKWQT MIEAHVDVKT TDGYLLRLFC VGFTKKRNNQ IRKTSYAQHQ Q VRQIRKKM MEIMTREVQT NDLKEVVNKL IPDSIGKDIE KACQSIYPLH DVFVRKVKML KKPKFELGKL MELHGEGSSS GK ATGDETG AKVERADGYE PPVQESV

UniProtKB: Small ribosomal subunit protein eS1

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分子 #20: 40S ribosomal protein S2

分子名称: 40S ribosomal protein S2 / タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 31.376516 KDa
配列文字列: MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIK ESEIIDFFLG ASLKDEVLKI MPVQKQTRAG QRTRFKAFVA IGDYNGHVGL GVKCSKEVAT AIRGAIILAK L SIVPVRRG ...文字列:
MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIK ESEIIDFFLG ASLKDEVLKI MPVQKQTRAG QRTRFKAFVA IGDYNGHVGL GVKCSKEVAT AIRGAIILAK L SIVPVRRG YWGNKIGKPH TVPCKVTGRC GSVLVRLIPA PRGTGIVSAP VPKKLLMMAG IDDCYTSARG CTATLGNFAK AT FDAISKT YSYLTPDLWK ETVFTKSPYQ EFTDHLVKTH TRVSVQRTQA PAVATT

UniProtKB: Small ribosomal subunit protein uS5

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分子 #21: 40S ribosomal protein S3

分子名称: 40S ribosomal protein S3 / タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO / EC番号: DNA-(apurinic or apyrimidinic site) lyase
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 26.729369 KDa
配列文字列: MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH S GDPVNYYV ...文字列:
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH S GDPVNYYV DTAVRHVLLR QGVLGIKVKI MLPWDPTGKI GPKKPLPDHV SIVEPKDEIL PTTPISEQKG GKPEPPAMPQ PV PTA

UniProtKB: Small ribosomal subunit protein uS3

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分子 #22: 40S ribosomal protein S4, X isoform

分子名称: 40S ribosomal protein S4, X isoform / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 29.654869 KDa
配列文字列: MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDV ISIDKTGENF RLIYDTKGRF AVHRITPEEA KYKLCKVRKI FVGTKGIPHL VTHDARTIRY PDPLIKVNDT I QIDLETGK ...文字列:
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDV ISIDKTGENF RLIYDTKGRF AVHRITPEEA KYKLCKVRKI FVGTKGIPHL VTHDARTIRY PDPLIKVNDT I QIDLETGK ITDFIKFDTG NLCMVTGGAN LGRIGVITNR ERHPGSFDVV HVKDANGNSF ATRLSNIFVI GKGNKPWISL PR GKGIRLT IAEERDKRLA AKQSSG

UniProtKB: Small ribosomal subunit protein eS4, X isoform

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分子 #23: 40S ribosomal protein S5

分子名称: 40S ribosomal protein S5 / タイプ: protein_or_peptide / ID: 23 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 22.913453 KDa
配列文字列: MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMT VRIVKHAFEI IHLLTGENPL QVLVNAIINS GPREDSTRIG RAGTVRRQAV DVSPLRRVNQ AIWLLCTGAR E AAFRNIKT ...文字列:
MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMT VRIVKHAFEI IHLLTGENPL QVLVNAIINS GPREDSTRIG RAGTVRRQAV DVSPLRRVNQ AIWLLCTGAR E AAFRNIKT IAECLADELI NAAKGSSNSY AIKKKDELER VAKSNR

UniProtKB: Small ribosomal subunit protein uS7

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分子 #24: 40S ribosomal protein S6

分子名称: 40S ribosomal protein S6 / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 28.751906 KDa
配列文字列: MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK ...文字列:
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK PRTKAPKIQR LVTPRVLQHK RRRIALKKQR TKKNKEEAAE YAKLLAKRMK EAKEKRQEQI AKRRRLSSLR AS TSKSESS QK

UniProtKB: Small ribosomal subunit protein eS6

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分子 #25: 40S ribosomal protein S7

分子名称: 40S ribosomal protein S7 / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 22.168914 KDa
配列文字列: MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSG KHVVFIAQRR ILPKPTRKSR TKNKQKRPRS RTLTAVHDAI LEDLVFPSEI VGKRIRVKLD GSRLIKVHLD K AQQNNVEH ...文字列:
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSG KHVVFIAQRR ILPKPTRKSR TKNKQKRPRS RTLTAVHDAI LEDLVFPSEI VGKRIRVKLD GSRLIKVHLD K AQQNNVEH KVETFSGVYK KLTGKDVNFE FPEFQL

UniProtKB: Small ribosomal subunit protein eS7

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分子 #26: 40S ribosomal protein S8

分子名称: 40S ribosomal protein S8 / タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 24.263387 KDa
配列文字列: MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNE LVRTKTLVKN CIVLIDSTPY RQWYESHYAL PLGRKKGAKL TPEEEEILNK KRSKKIQKKY DERKKNAKIS S LLEEQFQQ ...文字列:
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNE LVRTKTLVKN CIVLIDSTPY RQWYESHYAL PLGRKKGAKL TPEEEEILNK KRSKKIQKKY DERKKNAKIS S LLEEQFQQ GKLLACIASR PGQCGRADGY VLEGKELEFY LRKIKARKGK

UniProtKB: Small ribosomal subunit protein eS8

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分子 #27: 40S ribosomal protein S9

分子名称: 40S ribosomal protein S9 / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 22.641564 KDa
配列文字列: MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDE GKMKLDYILG LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFIV RLDSQKHIDF S LRSPYGGG ...文字列:
MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDE GKMKLDYILG LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFIV RLDSQKHIDF S LRSPYGGG RPGRVKRKNA KKGQGGAGAG DDEEED

UniProtKB: Small ribosomal subunit protein uS4

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分子 #28: 40S ribosomal protein S10

分子名称: 40S ribosomal protein S10 / タイプ: protein_or_peptide / ID: 28 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 18.933846 KDa
配列文字列:
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEI VPATLRRSRP ETGRPRPKGL EGERPARLTR GEADRDTYRR SAVPPGADKK AEAGAGSATE FQFRGGFGRG R GQPPQ

UniProtKB: Small ribosomal subunit protein eS10

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分子 #29: 40S ribosomal protein S11

分子名称: 40S ribosomal protein S11 / タイプ: protein_or_peptide / ID: 29 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 18.468826 KDa
配列文字列:
MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA IEGTYIDKKC PFTGNVSIRG RILSGVVTKM KMQRTIVIR RDYLHYIRKY NRFEKRHKNM SVHLSPCFRD VQIGDIVTVG ECRPLSKTVR FNVLKVTKAA GTKKQFQKF

UniProtKB: Small ribosomal subunit protein uS17

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分子 #30: 40S ribosomal protein S12

分子名称: 40S ribosomal protein S12 / タイプ: protein_or_peptide / ID: 30 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 14.548896 KDa
配列文字列:
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VQASNCDEPM YVKLVEALLA EHQINLIKVD DNKKLGEWV GLCKIDREGN PRKVVGCSCV VVKDYGKESQ AKDVIEEYFK CKK

UniProtKB: Small ribosomal subunit protein eS12

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分子 #31: 40S ribosomal protein S13

分子名称: 40S ribosomal protein S13 / タイプ: protein_or_peptide / ID: 31 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 17.259389 KDa
配列文字列:
MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLY HLIKKAVAVR KHLERNRKDK DAKFRLILIE SRIHRLARYY KTKRVLPPNW KYESSTASAL VA

UniProtKB: Small ribosomal subunit protein uS15

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分子 #32: 40S ribosomal protein S14

分子名称: 40S ribosomal protein S14 / タイプ: protein_or_peptide / ID: 32 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 16.302772 KDa
配列文字列:
MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELG ITALHIKLRA TGGNRTKTPG PGAQSALRAL ARSGMKIGRI EDVTPIPSDS TRRKGGRRGR RL

UniProtKB: Small ribosomal subunit protein uS11

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分子 #33: 40S ribosomal protein S15

分子名称: 40S ribosomal protein S15 / タイプ: protein_or_peptide / ID: 33 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 17.076207 KDa
配列文字列:
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEM VGSMVGVYNG KTFNQVEIKP EMIGHYLGEF SITYKPVKHG RPGIGATHSS RFIPLK

UniProtKB: Small ribosomal subunit protein uS19

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分子 #34: 40S ribosomal protein S16

分子名称: 40S ribosomal protein S16 / タイプ: protein_or_peptide / ID: 34 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 16.477377 KDa
配列文字列:
MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK LLEPVLLLGK ERFAGVDIRV RVKGGGHVAQ IYAIRQSIS KALVAYYQKY VDEASKKEIK DILIQYDRTL LVADPRRCES KKFGGPGARA RYQKSYR

UniProtKB: Small ribosomal subunit protein uS9

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分子 #35: 40S ribosomal protein S17

分子名称: 40S ribosomal protein S17 / タイプ: protein_or_peptide / ID: 35 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 15.578156 KDa
配列文字列:
MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVS ALDQEIIEVD PDTKEMLKLL DFGSLSNLQV TQPTVGMNFK TPRGPV

UniProtKB: Small ribosomal subunit protein eS17

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分子 #36: 40S ribosomal protein S18

分子名称: 40S ribosomal protein S18 / タイプ: protein_or_peptide / ID: 36 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 17.759777 KDa
配列文字列:
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKD VKDGKYSQVL ANGLDNKLRE DLERLKKIRA HRGLRHFWGL RVRGQHTKTT GRRGRTVGVS KKK

UniProtKB: Small ribosomal subunit protein uS13

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分子 #37: 40S ribosomal protein S19

分子名称: 40S ribosomal protein S19 / タイプ: protein_or_peptide / ID: 37 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 16.091562 KDa
配列文字列:
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMP SHFSRGSKSV ARRVLQALEG LKMVEKDQDG GRKLTPQGQR DLDRIAGQVA AANKKH

UniProtKB: Small ribosomal subunit protein eS19

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分子 #38: 40S ribosomal protein S20

分子名称: 40S ribosomal protein S20 / タイプ: protein_or_peptide / ID: 38 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 13.398763 KDa
配列文字列:
MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV KGPVRMPTKT LRITTRKTPC GEGSKTWDRF QMRIHKRLI DLHSPSEIVK QITSISIEPG VEVEVTIADA

UniProtKB: Small ribosomal subunit protein uS10

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分子 #39: 40S ribosomal protein S21

分子名称: 40S ribosomal protein S21 / タイプ: protein_or_peptide / ID: 39 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 9.124389 KDa
配列文字列:
MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR RMGESDDSIL RLAKADGIVS KNF

UniProtKB: Small ribosomal subunit protein eS21

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分子 #40: 40S ribosomal protein S15a

分子名称: 40S ribosomal protein S15a / タイプ: protein_or_peptide / ID: 40 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 14.865555 KDa
配列文字列:
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKW QNNLLPSRQF GFIVLTTSAG IMDHEEARRK HTGGKILGFF F

UniProtKB: Small ribosomal subunit protein uS8

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分子 #41: 40S ribosomal protein S23

分子名称: 40S ribosomal protein S23 / タイプ: protein_or_peptide / ID: 41 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 15.844666 KDa
配列文字列:
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDG CLNFIEENDE VLVAGFGRKG HAVGDIPGVR FKVVKVANVS LLALYKGKKE RPRS

UniProtKB: Small ribosomal subunit protein uS12

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分子 #42: 40S ribosomal protein S24

分子名称: 40S ribosomal protein S24 / タイプ: protein_or_peptide / ID: 42 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 15.463333 KDa
配列文字列:
MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKH RLARHGLYEK KKTSRKQRKE RKNRMKKVRG TAKANVGAGK KPKE

UniProtKB: Small ribosomal subunit protein eS24

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分子 #43: 40S ribosomal protein S25

分子名称: 40S ribosomal protein S25 / タイプ: protein_or_peptide / ID: 43 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 13.776224 KDa
配列文字列:
MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF DKATYDKLCK EVPNYKLITP AVVSERLKIR GSLARAALQ ELLSKGLIKL VSKHRAQVIY TRNTKGGDAP AAGEDA

UniProtKB: Small ribosomal subunit protein eS25

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分子 #44: 40S ribosomal protein S26

分子名称: 40S ribosomal protein S26 / タイプ: protein_or_peptide / ID: 44 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 13.047532 KDa
配列文字列:
MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSR EARKDRTPPP RFRPAGAAPR PPPKPM

UniProtKB: Small ribosomal subunit protein eS26

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分子 #45: 40S ribosomal protein S27

分子名称: 40S ribosomal protein S27 / タイプ: protein_or_peptide / ID: 45 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 9.480186 KDa
配列文字列:
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH

UniProtKB: Small ribosomal subunit protein eS27

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分子 #46: 40S ribosomal protein S28

分子名称: 40S ribosomal protein S28 / タイプ: protein_or_peptide / ID: 46 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 7.855052 KDa
配列文字列:
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE SEREARRLR

UniProtKB: Small ribosomal subunit protein eS28

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分子 #47: 40S ribosomal protein S29

分子名称: 40S ribosomal protein S29 / タイプ: protein_or_peptide / ID: 47 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 6.690821 KDa
配列文字列:
MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

UniProtKB: Small ribosomal subunit protein uS14

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分子 #48: 40S ribosomal protein S30

分子名称: 40S ribosomal protein S30 / タイプ: protein_or_peptide / ID: 48 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 6.668938 KDa
配列文字列:
KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG KKKGPNANS

UniProtKB: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

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分子 #49: Ubiquitin

分子名称: Ubiquitin / タイプ: protein_or_peptide / ID: 49 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 18.004041 KDa
配列文字列:
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPK KNKHKRKKVK LAVLKYYKVD ENGKISRLRR ECPSDECGAG VFMASHFDRH YCGKCCLTYC FNKPEDK

UniProtKB: Ubiquitin-ribosomal protein eS31 fusion protein

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分子 #50: Receptor of activated protein C kinase 1

分子名称: Receptor of activated protein C kinase 1 / タイプ: protein_or_peptide / ID: 50 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 35.115652 KDa
配列文字列: MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRL WDLTTGTTTR RFVGHTKDVL SVAFSSDNRQ IVSGSRDKTI KLWNTLGVCK YTVQDESHSE WVSCVRFSPN S SNPIIVSC ...文字列:
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRL WDLTTGTTTR RFVGHTKDVL SVAFSSDNRQ IVSGSRDKTI KLWNTLGVCK YTVQDESHSE WVSCVRFSPN S SNPIIVSC GWDKLVKVWN LANCKLKTNH IGHTGYLNTV TVSPDGSLCA SGGKDGQAML WDLNEGKHLY TLDGGDIINA LC FSPNRYW LCAATGPSIK IWDLEGKIIV DELKQEVIST SSKAEPPQCT SLAWSADGQT LFAGYTDNLV RVWQVTIGTR

UniProtKB: Small ribosomal subunit protein RACK1

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分子 #14: CrPV-IRES RNA

分子名称: CrPV-IRES RNA / タイプ: rna / ID: 14 / コピー数: 1
由来(天然)生物種: Cricket paralysis virus (ウイルス)
分子量理論値: 79.333953 KDa
配列文字列: AAAAAUGUGA UCUUGCUGUG UAAAUACAAU UUUGAGAGGU UAAUAAAUUA CAAGUAGUGC UAUUUUUGUA UUUAGGUUAG CUAUUUAGC UUUACGUUCC AGGAUGCCUA GUGGCAGCCC CACAAUAUCC AGGAAGCCCU CUCUGCGGUU CGAAAAACCU U UUUAGGUA ...文字列:
AAAAAUGUGA UCUUGCUGUG UAAAUACAAU UUUGAGAGGU UAAUAAAUUA CAAGUAGUGC UAUUUUUGUA UUUAGGUUAG CUAUUUAGC UUUACGUUCC AGGAUGCCUA GUGGCAGCCC CACAAUAUCC AGGAAGCCCU CUCUGCGGUU CGAAAAACCU U UUUAGGUA UUUGGUUUUU CUAAGAAAUU UACCUAUUUU UAAAAAAAUU UUUUUUUUUU UUUUUUUUUU UUUUCUCCUC UU UUUUUUU UUU

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分子 #17: 18S ribosomal RNA

分子名称: 18S ribosomal RNA / タイプ: rna / ID: 17 / コピー数: 1
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 602.752875 KDa
配列文字列: UACCUGGUUG AUCCUGCCAG UAGCAUAUGC UUGUCUCAAA GAUUAAGCCA UGCAUGUCUA AGUACGCACG GCCGGUACAG UGAAACUGC GAAUGGCUCA UUAAAUCAGU UAUGGUUCCU UUGGUCGCUC GCUCCUCUCC CACUUGGAUA ACUGUGGUAA U UCUAGAGC ...文字列:
UACCUGGUUG AUCCUGCCAG UAGCAUAUGC UUGUCUCAAA GAUUAAGCCA UGCAUGUCUA AGUACGCACG GCCGGUACAG UGAAACUGC GAAUGGCUCA UUAAAUCAGU UAUGGUUCCU UUGGUCGCUC GCUCCUCUCC CACUUGGAUA ACUGUGGUAA U UCUAGAGC UAAUACAUGC CGACGGGCGC UGACCCCCUU CGCGGGGGGG AUGCGUGCAU UUAUCAGAUC AAAACCAACC CG GUCAGCC CCUCUCCGGC CCCGGCCGGG GGGCGGGCGC CGGCGGCUUU GGUGACUCUA GAUAACCUCG GGCCGAUCGC ACG CCCCCC GUGGCGGCGA CGACCCAUUC GAACGUCUGC CCUAUCAACU UUCGAUGGUA GUCGCCGUGC CUACCAUGGU GACC ACGGG UGACGGGGAA UCAGGGUUCG AUUCCGGAGA GGGAGCCUGA GAAACGGCUA CCACAUCCAA GGAAGGCAGC AGGCG CGCA AAUUACCCAC UCCCGACCCG GGGAGGUAGU GACGAAAAAU AACAAUACAG GACUCUUUCG AGGCCCUGUA AUUGGA AUG AGUCCACUUU AAAUCCUUCC GCGAGGAUCC AUUGGAGGGC AAGUCUGGUG CCAGCAGCCG CGGUAAUUCC AGCUCCA AU AGCGUAUAUU AAAGUUGCUG CAGUUAAAAA GCUCGUAGUU GGAUCUUGGG AGCGGGCGGG CGGUCCGCCG CGAGGCGA G CCACCGCCCG UCCCCGCCCC UUGCCUCUCG GCGCCCCCUC GAUGCUCUUA GCUGAGUGUC CCGCGGGGCC CGAAGCAUU UACUUUGAAA AAAUUAGAGU GUUCAAAGCA GGCCCGAGCC GCCUGGAUAC CGCAGCUAGG AAUAAUGGAA UAGGACCGCG GUUCUAUUU UGUUGGUUUU CGGAACUGAG GCCAUGAUUA AGAGGGACGG CCGGGGGCAU UCGUAUUGCG CCGCUAGAGG U GAAAUUCU UGGACCGGCG CAAGACGGAC CAGAGCGAAA GCAUUUGCCA AGAAUGUUUU CAUUAAUCAA GAACGAAAGU CG GAGGUUC GAAGACGAUC AGAUACCGUC GUAGUUCCGA CCAUAAACGA UGCCGACUGG CGAUGCGGCG GCGUUAUUCC CAU GACCCG CCGGGCAGCU UCCGGGAAAC CAAAGUCUUU GGGUUCCGGG GGGAGUAUGG UUGCAAAGCU GAAACUUAAA GGAA UUGAC GGAAGGGCAC CACCAGGAGU GGAGCCUGCG GCUUAAUUUG ACUCAACACG GGAAACCUCA CCCGGCCCGG ACACG GACA GGAUUGACAG AUUGAUAGCU CUUUCUCGAU UCCGUGGGUG GUGGUGCAUG GCCGUUCUUA GUUGGUGGAG CGAUUU GUC UGGUUAAUUC CGAUAACGAA CGAGACUCUG GCAUGCUAAC UAGUUACGCG ACCCCCGAGC GGUCGGCGUC CCCCAAC UU CUUAGAGGGA CAAGUGGCGU UCAGCCACCC GAGAUUGAGC AAUAACAGGU CUGUGAUGCC CUUAGAUGUC CGGGGCUG C ACGCGCGCUA CACUGACUGG CUCAGCGUGU GCCUACCCUA CGCCGGCAGG CGCGGGUAAC CCGUUGAACC CCAUUCGUG AUGGGGAUCG GGGAUUGCAA UUAUUCCCCA UGAACGAGGA AUUCCCAGUA AGUGCGGGUC AUAAGCUUGC GUUGAUUAAG UCCCUGCCC UUUGUACACA CCGCCCGUCG CUACUACCGA UUGGAUGGUU UAGUGAGGCC CUCGGAUCGG CCCCGCCGGG G UCGGCCCA CGGCCCUGGC GGAGCGCUGA GAAGACGGUC GAACUUGACU AUCUAGAGGA AGUAAAAGUC GUAACAAGGU UU CCGUAGG UGAACCUGCG GAAGGAUCAU UA

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 7.4
グリッドモデル: Quantifoil R2/1 / メッシュ: 200 / 支持フィルム - 材質: CARBON / 支持フィルム - トポロジー: CONTINUOUS / 前処理 - タイプ: GLOW DISCHARGE
凍結凍結剤: ETHANE-PROPANE

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電子顕微鏡法

顕微鏡FEI TITAN KRIOS
撮影フィルム・検出器のモデル: GATAN K3 BIOQUANTUM (6k x 4k)
平均電子線量: 64.2 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / 最大 デフォーカス(公称値): 2.4 µm / 最小 デフォーカス(公称値): 0.6 µm
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

初期モデルモデルのタイプ: PDB ENTRY
PDBモデル - PDB ID:
最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 3.4 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 53460
初期 角度割当タイプ: MAXIMUM LIKELIHOOD
最終 角度割当タイプ: MAXIMUM LIKELIHOOD
FSC曲線 (解像度の算出)

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月:コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか? / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例:em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

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