登録情報 | データベース: PDB / ID: 4mgy |
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タイトル | Selective activation of Epac1 and Epac2 |
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要素 | - Rap guanine nucleotide exchange factor 4
- Ras-related protein Rap-1b
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キーワード | SIGNALING PROTEIN/GTP-BINDING PROTEIN / Guanine Nucleotide Exchange Factor / Nucleotide Binding / SIGNALING PROTEIN-GTP-BINDING PROTEIN complex |
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機能・相同性 | 機能・相同性情報
cone cell pedicle / Rap protein signal transduction / Integrin signaling / positive regulation of neuronal action potential / modification of postsynaptic structure / regulation of dendrite development / Rap1 signalling / regulation of cell junction assembly / Regulation of insulin secretion / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ...cone cell pedicle / Rap protein signal transduction / Integrin signaling / positive regulation of neuronal action potential / modification of postsynaptic structure / regulation of dendrite development / Rap1 signalling / regulation of cell junction assembly / Regulation of insulin secretion / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / positive regulation of integrin activation / negative regulation of calcium ion-dependent exocytosis / regulation of synaptic vesicle cycle / regulation of exocytosis / negative regulation of synaptic vesicle exocytosis / hormone secretion / calcium-ion regulated exocytosis / Rap1 signalling / establishment of endothelial barrier / negative regulation of synaptic transmission / MET activates RAP1 and RAC1 / insulin secretion / regulation of establishment of cell polarity / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / regulation of postsynapse organization / azurophil granule membrane / p130Cas linkage to MAPK signaling for integrins / positive regulation of smooth muscle cell migration / brush border / GRB2:SOS provides linkage to MAPK signaling for Integrins / excitatory synapse / photoreceptor outer segment / cAMP binding / cellular response to cAMP / photoreceptor inner segment / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / Integrin signaling / hippocampal mossy fiber to CA3 synapse / lipid droplet / small monomeric GTPase / G protein activity / guanyl-nucleotide exchange factor activity / establishment of localization in cell / positive regulation of protein secretion / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / positive regulation of insulin secretion / adenylate cyclase-activating G protein-coupled receptor signaling pathway / small GTPase binding / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / GDP binding / Signaling by BRAF and RAF1 fusions / cell-cell junction / protein-macromolecule adaptor activity / growth cone / basolateral plasma membrane / Ras protein signal transduction / cell population proliferation / dendritic spine / positive regulation of ERK1 and ERK2 cascade / postsynaptic density / apical plasma membrane / axon / GTPase activity / neuronal cell body / glutamatergic synapse / dendrite / Neutrophil degranulation / protein-containing complex binding / GTP binding / protein-containing complex / extracellular exosome / membrane / plasma membrane / cytosol類似検索 - 分子機能 Helicase, Ruva Protein; domain 3 - #1240 / Ras-related protein Rap1 / Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain ...Helicase, Ruva Protein; domain 3 - #1240 / Ras-related protein Rap1 / Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / Ras guanine nucleotide exchange factor domain superfamily / RasGEF domain / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / Small GTPase, Ras-type / small GTPase Ras family profile. / Jelly Rolls / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Helicase, Ruva Protein; domain 3 / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / RmlC-like jelly roll fold / Small GTPase / Ras family / Rab subfamily of small GTPases / Ubiquitin-like (UB roll) / Small GTP-binding protein domain / Ubiquitin-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Winged helix DNA-binding domain superfamily / Jelly Rolls / Winged helix-like DNA-binding domain superfamily / Roll / Up-down Bundle / Sandwich / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-H07 / Ras-related protein Rap-1b / Rap guanine nucleotide exchange factor 4類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
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データ登録者 | Rehmann, H. |
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引用 | ジャーナル: To be Published タイトル: Selective activation of Epac1 and Epac2 著者: Rehmann, H. |
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履歴 | 登録 | 2013年8月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年9月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月15日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.2 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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