登録情報 | データベース: PDB / ID: 4m0r |
---|
タイトル | Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD). |
---|
要素 | Anthranilate phosphoribosyltransferase |
---|
キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Magnesium binding / phosphoribosylpyrophosphate / PRPP / inhibitor complex / tri-anthranilate analogue / TB Structural Genomics Consortium / TBSGC / phosphoribosyltransferase / transferase / TRANSFERASE-TRANSFERASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
anthranilate phosphoribosyltransferase / anthranilate phosphoribosyltransferase activity / tryptophan biosynthetic process / magnesium ion binding / extracellular region / plasma membrane / cytosol類似検索 - 分子機能 Anthranilate phosphoribosyl transferase / Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C / Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 / Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain / Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 / Glycosyl transferase family 3, N-terminal domain / Glycosyl transferase family 3, N-terminal domain superfamily / Glycosyl transferase family, helical bundle domain / Glycosyl transferase, family 3 / Glycosyl transferase family, a/b domain ...Anthranilate phosphoribosyl transferase / Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C / Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 / Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain / Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 / Glycosyl transferase family 3, N-terminal domain / Glycosyl transferase family 3, N-terminal domain superfamily / Glycosyl transferase family, helical bundle domain / Glycosyl transferase, family 3 / Glycosyl transferase family, a/b domain / Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily / Up-down Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 2,6-bis[(2-carboxyphenyl)amino]benzoic acid / IMIDAZOLE / Anthranilate phosphoribosyltransferase / Anthranilate phosphoribosyltransferase類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (結核菌) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.96 Å |
---|
データ登録者 | Evans, G.L. / Baker, E.N. / Lott, J.S. / TB Structural Genomics Consortium (TBSGC) |
---|
引用 | ジャーナル: Chembiochem / 年: 2014 タイトル: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. 著者: Evans, G.L. / Gamage, S.A. / Bulloch, E.M. / Baker, E.N. / Denny, W.A. / Lott, J.S. |
---|
履歴 | 登録 | 2013年8月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2014年5月21日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.2 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|