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-Structure paper
Title | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. |
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Journal, issue, pages | Chembiochem, Vol. 15, Page 852-864, Year 2014 |
Publish date | Aug 9, 2012 (structure data deposition date) |
Authors | Evans, G.L. / Gamage, S.A. / Bulloch, E.M. / Baker, E.N. / Denny, W.A. / Lott, J.S. |
External links | Chembiochem / PubMed:24623674 |
Methods | X-ray diffraction |
Resolution | 1.667 - 1.96 Å |
Structure data | PDB-4giu: PDB-4gkm: PDB-4ij1: PDB-4m0r: |
Chemicals | ChemComp-PRP: ChemComp-MG: ChemComp-636: ChemComp-GOL: ChemComp-DMS: ChemComp-HOH: ChemComp-683: ChemComp-17C: ChemComp-IMD: ChemComp-644: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Magnesium binding / phophoribosylpyrophosphate / PRPP / inhibitor complex / bi-anthranilate-like analogue / TB Structural Genomics Consortium / TBSGC / phosphoribosyltransferase / TRANSFERASE-TRANSFERASE INHIBITOR complex / phosphoribosylpyrophosphate / bi-anthranilate analogue / tri-anthranilate analogue / transferase |