- PDB-3uvc: MMP12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)... -
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データを開く
IDまたはキーワード:
読み込み中...
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基本情報
登録情報
データベース: PDB / ID: 3uvc
タイトル
MMP12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5-phenylhydantoin
要素
Macrophage metalloelastase
キーワード
HYDROLASE / metalloprotease
機能・相同性
機能・相同性情報
macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development ...macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development / response to amyloid-beta / positive regulation of interferon-alpha production / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / core promoter sequence-specific DNA binding / collagen binding / Degradation of the extracellular matrix / extracellular matrix / extracellular matrix organization / cellular response to virus / metalloendopeptidase activity / protein import into nucleus / endopeptidase activity / sequence-specific DNA binding / serine-type endopeptidase activity / calcium ion binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / proteolysis / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm 類似検索 - 分子機能
Rfactor: 44.38 / Model details: Phaser MODE: MR_AUTO
最高解像度
最低解像度
Rotation
2.5 Å
41.48 Å
Translation
2.5 Å
41.48 Å
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解析
ソフトウェア
名称
バージョン
分類
NB
MOSFLM
データ削減
SCALA
3.2.25
データスケーリング
PHASER
2.1.4
位相決定
REFMAC
精密化
PDB_EXTRACT
3.1
データ抽出
ADSC
Quantum
データ収集
精密化
構造決定の手法: 分子置換 開始モデル: internal model: V108-L261 no metal ions. 解像度: 1.3→41.487 Å / Cor.coef. Fo:Fc: 0.981 / Cor.coef. Fo:Fc free: 0.962 / WRfactor Rfree: 0.1836 / WRfactor Rwork: 0.1327 / Occupancy max: 1 / Occupancy min: 0 / FOM work R set: 0.889 / SU B: 1.931 / SU ML: 0.036 / SU R Cruickshank DPI: 0.0537 / SU Rfree: 0.0522 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.054 / ESU R Free: 0.052 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : RESIDUAL ONLY
Rfactor
反射数
%反射
Selection details
Rfree
0.1736
3294
5.1 %
RANDOM
Rwork
0.1302
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obs
0.1324
64982
100 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: BABINET MODEL WITH MASK