登録情報 データベース : PDB / ID : 3hrf 構造の表示 ダウンロードとリンクタイトル Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket 要素3-phosphoinositide-dependent protein kinase 1 詳細 キーワード TRANSFERASE / AGC KINASE / PHOSPHORYLATION / ALLOSTERY / PDK1 / PIF-POCKET / ALPHA-C HELIX / ACTIVATION LOOP / ATP BINDING / ATP-binding / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
3-phosphoinositide-dependent protein kinase activity / Activation of AKT2 / regulation of mast cell degranulation / negative regulation of toll-like receptor signaling pathway / type B pancreatic cell development / positive regulation of phospholipase activity / hyperosmotic response / RSK activation / regulation of canonical NF-kappaB signal transduction / positive regulation of vascular endothelial cell proliferation ... 3-phosphoinositide-dependent protein kinase activity / Activation of AKT2 / regulation of mast cell degranulation / negative regulation of toll-like receptor signaling pathway / type B pancreatic cell development / positive regulation of phospholipase activity / hyperosmotic response / RSK activation / regulation of canonical NF-kappaB signal transduction / positive regulation of vascular endothelial cell proliferation / negative regulation of cardiac muscle cell apoptotic process / phospholipase activator activity / positive regulation of sprouting angiogenesis / Constitutive Signaling by AKT1 E17K in Cancer / CD28 dependent PI3K/Akt signaling / phospholipase binding / positive regulation of blood vessel endothelial cell migration / Role of LAT2/NTAL/LAB on calcium mobilization / Estrogen-stimulated signaling through PRKCZ / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / negative regulation of endothelial cell apoptotic process / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / extrinsic apoptotic signaling pathway / RHO GTPases activate PKNs / cellular response to epidermal growth factor stimulus / GPVI-mediated activation cascade / T cell costimulation / activation of protein kinase B activity / Integrin signaling / insulin-like growth factor receptor signaling pathway / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated vascular permeability / VEGFR2 mediated cell proliferation / cell projection / positive regulation of protein localization to plasma membrane / peptidyl-threonine phosphorylation / calcium-mediated signaling / negative regulation of transforming growth factor beta receptor signaling pathway / negative regulation of protein kinase activity / epidermal growth factor receptor signaling pathway / CLEC7A (Dectin-1) signaling / FCERI mediated NF-kB activation / cellular response to insulin stimulus / G beta:gamma signalling through PI3Kgamma / positive regulation of angiogenesis / Regulation of TP53 Degradation / cell migration / Downstream TCR signaling / insulin receptor signaling pathway / PIP3 activates AKT signaling / actin cytoskeleton organization / cytoplasmic vesicle / protein autophosphorylation / postsynaptic density / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 PDK1-type, PH domain / PDPK1 family / PH domain / : / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site ... PDK1-type, PH domain / PDPK1 family / PH domain / : / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 ADENOSINE-5'-TRIPHOSPHATE / (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid / 3-phosphoinositide-dependent protein kinase 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Hindie, V. / Alzari, P.M. / Biondi, R.M. 引用ジャーナル : Nat.Chem.Biol. / 年 : 2009タイトル : Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
著者 :
Hindie, V. / Stroba, A. / Zhang, H. / Lopez-Garcia, L.A. / Idrissova, L. / Zeuzem, S. / Hirschberg, D. / Schaeffer, F. / Jrgensen, T.J. / Engel, M. / Alzari, P.M. / Biondi, R.M. 残り1件を表示 表示を減らす#1: ジャーナル : To be Published タイトル: 3,5-diphenyl pent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterisation of binding as a paradigm for PIF- ... タイトル : 3,5-diphenyl pent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterisation of binding as a paradigm for PIF-binding pocket-targeting compounds著者 :
Stroba, A. / Schaeffer, F. / Hindie, V. / Lopez-Garcia, L.A. / Frohner, W. / Adrian, I. / Hartmann, R.W. / Biondi, R.M. / Engel, M. 履歴 登録 2009年6月9日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2009年9月15日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Refinement description / Version format compliance改定 1.2 2013年11月13日 Group : Database references改定 1.3 2021年11月10日 Group : Database references / Derived calculationsカテゴリ : database_2 / struct_conn ... database_2 / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.4 2023年11月1日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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