登録情報 データベース : PDB / ID : 3db8 構造の表示 ダウンロードとリンクタイトル Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 041 要素Polo-like kinase 1 詳細 キーワード TRANSFERASE / Polo-like kinase 1 / Plk1 / catalytic domain / small-molecule inhibitor / Kinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Polo-like kinase mediated events / Phosphorylation of Emi1 / Condensation of Prophase Chromosomes / Resolution of Sister Chromatid Cohesion / Mitotic Metaphase/Anaphase Transition / Mitotic Telophase/Cytokinesis / Cyclin A/B1/B2 associated events during G2/M transition / EML4 and NUDC in mitotic spindle formation / Regulation of PLK1 Activity at G2/M Transition / The role of GTSE1 in G2/M progression after G2 checkpoint ... Polo-like kinase mediated events / Phosphorylation of Emi1 / Condensation of Prophase Chromosomes / Resolution of Sister Chromatid Cohesion / Mitotic Metaphase/Anaphase Transition / Mitotic Telophase/Cytokinesis / Cyclin A/B1/B2 associated events during G2/M transition / EML4 and NUDC in mitotic spindle formation / Regulation of PLK1 Activity at G2/M Transition / The role of GTSE1 in G2/M progression after G2 checkpoint / polo kinase / mitotic spindle organization / kinetochore / spindle pole / retina development in camera-type eye / mitotic cell cycle / cell division / protein serine/threonine kinase activity / centrosome / ATP binding / nucleus / cytoplasm 類似検索 - 分子機能 Polo-like kinase 1, catalytic domain / Second polo-box domain / First polo-box domain / POLO box domain superfamily / POLO box duplicated region / POLO box domain / POLO box domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 ... Polo-like kinase 1, catalytic domain / Second polo-box domain / First polo-box domain / POLO box domain superfamily / POLO box duplicated region / POLO box domain / POLO box domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-1FR / Serine/threonine-protein kinase PLK 類似検索 - 構成要素生物種 Danio rerio (ゼブラフィッシュ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.15 Å 詳細データ登録者 Elling, R.A. / Hanan, E.J. / Lew, W. / Romanowski, M.J. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2008タイトル : Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.著者 : Hanan, E.J. / Fucini, R.V. / Romanowski, M.J. / Elling, R.A. / Lew, W. / Purkey, H.E. / VanderPorten, E.C. / Yang, W. 履歴 登録 2008年5月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年10月7日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2021年10月20日 Group : Database references / Derived calculations / カテゴリ : database_2 / struct_ref_seq_dif / struct_siteItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.3 2023年8月30日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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