登録情報 | データベース: PDB / ID: 3cjf |
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タイトル | Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine |
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要素 | Vascular endothelial growth factor receptor 2血管内皮細胞増殖因子受容体 |
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キーワード | TRANSFERASE (転移酵素) / Vascular endothelial growth factor receptor 2. vegfr-2 / kinase insert domain receptor / protein-tyrosine kinase receptor flk-1 / Angiogenesis (血管新生) / ATP-binding / Developmental protein (ヒトの発達) / Differentiation / Glycoprotein (糖タンパク質) / Host-virus interaction / Immunoglobulin domain (免疫グロブリンフォールド) / Membrane (生体膜) / Nucleotide-binding / Phosphoprotein / Transmembrane (膜貫通型タンパク質) / Tyrosine-protein kinase |
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機能・相同性 | 機能・相同性情報
blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / regulation of bone development / Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / vascular endothelial growth factor binding / Neurophilin interactions with VEGF and VEGFR / endothelium development / vascular endothelial growth factor receptor-2 signaling pathway / VEGF binds to VEGFR leading to receptor dimerization / endocardium development ...blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / regulation of bone development / Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / vascular endothelial growth factor binding / Neurophilin interactions with VEGF and VEGFR / endothelium development / vascular endothelial growth factor receptor-2 signaling pathway / VEGF binds to VEGFR leading to receptor dimerization / endocardium development / vascular wound healing / vascular endothelial growth factor receptor activity / regulation of hematopoietic progenitor cell differentiation / post-embryonic camera-type eye morphogenesis / endothelial cell differentiation / mesenchymal cell proliferation / positive regulation of vasculogenesis / lymph vessel development / positive regulation of BMP signaling pathway / surfactant homeostasis / cell migration involved in sprouting angiogenesis / anchoring junction / epithelial cell maturation / positive regulation of positive chemotaxis / embryonic hemopoiesis / vascular endothelial growth factor signaling pathway / positive regulation of endothelial cell chemotaxis / positive regulation of mesenchymal cell proliferation / positive regulation of mitochondrial depolarization / branching involved in blood vessel morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of mitochondrial fission / lung alveolus development / positive regulation of stem cell proliferation / positive regulation of nitric-oxide synthase biosynthetic process / sorting endosome / growth factor binding / positive regulation of focal adhesion assembly / regulation of MAPK cascade / semaphorin-plexin signaling pathway / positive regulation of macroautophagy / : / positive regulation of blood vessel endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / 細胞分化 / calcium ion homeostasis / Integrin cell surface interactions / 脈管形成 / vascular endothelial growth factor receptor signaling pathway / coreceptor activity / negative regulation of endothelial cell apoptotic process / peptidyl-tyrosine autophosphorylation / ovarian follicle development / positive regulation of endothelial cell proliferation / transmembrane receptor protein tyrosine kinase activity / positive regulation of endothelial cell migration / VEGFR2 mediated cell proliferation / epithelial cell proliferation / stem cell proliferation / cell surface receptor protein tyrosine kinase signaling pathway / Hsp90 protein binding / 受容体型チロシンキナーゼ / VEGFA-VEGFR2 Pathway / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / 遊走 / integrin binding / 細胞結合 / regulation of cell shape / protein tyrosine kinase activity / 血管新生 / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / エンドソーム / positive regulation of ERK1 and ERK2 cascade / receptor complex / エンドソーム / positive regulation of cell migration / cadherin binding / 脂質ラフト / positive regulation of protein phosphorylation / external side of plasma membrane / negative regulation of gene expression / positive regulation of cell population proliferation / negative regulation of apoptotic process / ゴルジ体 / 小胞体 / extracellular region / ATP binding / identical protein binding / 細胞核 / 細胞膜類似検索 - 分子機能 Vascular endothelial growth factor receptor 2 (VEGFR2) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 免疫グロブリンフォールド / 抗体 / 免疫グロブリンフォールド / Immunoglobulin I-set ...Vascular endothelial growth factor receptor 2 (VEGFR2) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 免疫グロブリンフォールド / 抗体 / 免疫グロブリンフォールド / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / 抗体 / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-SAV / Vascular endothelial growth factor receptor 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.15 Å |
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データ登録者 | Nolte, R.T. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2008 タイトル: Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. 著者: Harris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. / Knick, V.B. / Laudeman, C.P. / Luttrell, D. ...著者: Harris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. / Knick, V.B. / Laudeman, C.P. / Luttrell, D.K. / Mook, R.A. / Nolte, R.T. / Rudolph, S.K. / Szewczyk, J.R. / Truesdale, A.T. / Veal, J.M. / Wang, L. / Stafford, J.A. |
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履歴 | 登録 | 2008年3月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年10月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
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改定 1.2 | 2017年8月23日 | Group: Source and taxonomy / カテゴリ: entity_src_gen |
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改定 1.3 | 2017年10月25日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.4 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.5 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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