Entry Database : PDB / ID : 2xzg Structure visualization Downloads & linksTitle Clathrin Terminal Domain Complexed with Pitstop 1 ComponentsCLATHRIN HEAVY CHAIN 1 Details Keywords ENDOCYTOSIS / ENDOCYTOSIS INHIBITIONFunction / homology Function and homology informationFunction Domain/homology Component
clathrin coat of trans-Golgi network vesicle / clathrin light chain binding / negative regulation of hyaluronan biosynthetic process / clathrin complex / clathrin coat / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / WNT5A-dependent internalization of FZD4 / Entry of Influenza Virion into Host Cell via Endocytosis / transferrin transport / amyloid-beta clearance by transcytosis ... clathrin coat of trans-Golgi network vesicle / clathrin light chain binding / negative regulation of hyaluronan biosynthetic process / clathrin complex / clathrin coat / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / WNT5A-dependent internalization of FZD4 / Entry of Influenza Virion into Host Cell via Endocytosis / transferrin transport / amyloid-beta clearance by transcytosis / clathrin coat of coated pit / mitotic spindle microtubule / clathrin coat disassembly / clathrin coat assembly / Retrograde neurotrophin signalling / clathrin-coated endocytic vesicle / LDL clearance / Formation of annular gap junctions / Gap junction degradation / clathrin-dependent endocytosis / ALK mutants bind TKIs / endolysosome membrane / retrograde transport, endosome to Golgi / negative regulation of protein localization to plasma membrane / clathrin-coated vesicle / Lysosome Vesicle Biogenesis / RHOV GTPase cycle / low-density lipoprotein particle receptor binding / Golgi Associated Vesicle Biogenesis / ubiquitin-specific protease binding / Recycling pathway of L1 / RHOU GTPase cycle / EPH-ephrin mediated repulsion of cells / regulation of mitotic spindle organization / MHC class II antigen presentation / VLDLR internalisation and degradation / receptor-mediated endocytosis / trans-Golgi network membrane / intracellular protein transport / clathrin-coated endocytic vesicle membrane / receptor internalization / mitotic spindle / autophagy / spindle / osteoblast differentiation / disordered domain specific binding / double-stranded RNA binding / extracellular vesicle / Signaling by ALK fusions and activated point mutants / melanosome / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / mitotic cell cycle / lysosome / endosome / cell division / focal adhesion / protein kinase binding / structural molecule activity / protein-containing complex / RNA binding / extracellular exosome / membrane / plasma membrane / cytosol Similarity search - Function Clathrin heavy-chain terminal domain / Clathrin, heavy chain, linker, core motif / Clathrin heavy chain, N-terminal / Clathrin, heavy chain / Clathrin, heavy chain, propeller repeat / Clathrin propeller repeat / Clathrin, heavy-chain linker / Clathrin-H-link / Region in Clathrin and VPS / Clathrin heavy chain repeat homology ... Clathrin heavy-chain terminal domain / Clathrin, heavy chain, linker, core motif / Clathrin heavy chain, N-terminal / Clathrin, heavy chain / Clathrin, heavy chain, propeller repeat / Clathrin propeller repeat / Clathrin, heavy-chain linker / Clathrin-H-link / Region in Clathrin and VPS / Clathrin heavy chain repeat homology / Clathrin, heavy chain/VPS, 7-fold repeat / Clathrin heavy-chain (CHCR) repeat profile. / 7 Propeller / Methylamine Dehydrogenase; Chain H / Tetratricopeptide-like helical domain superfamily / Armadillo-type fold / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MIR / Resolution : 1.7 Å DetailsAuthors Bulut, H. / Von Kleist, L. / Saenger, W. / Haucke, V. CitationJournal : Cell(Cambridge,Mass.) / Year : 2011Title : Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition.Authors: Von Kleist, L. / Stahlschmidt, W. / Bulut, H. / Gromova, K. / Puchkov, D. / Robertson, M.J. / Macgregor, K.A. / Tomlin, N. / Pechstein, A. / Chau, N. / Chircop, M. / Sakoff, J. / Von Kries, ... Authors : Von Kleist, L. / Stahlschmidt, W. / Bulut, H. / Gromova, K. / Puchkov, D. / Robertson, M.J. / Macgregor, K.A. / Tomlin, N. / Pechstein, A. / Chau, N. / Chircop, M. / Sakoff, J. / Von Kries, J.P. / Saenger, W. / Krausslich, H. / Shupliakov, O. / Robinson, P.J. / Mccluskey, A. / Haucke, V. History Deposition Nov 25, 2010 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 17, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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